Recombinant Human MPL Protein, C-His-tagged

Cat.No. : MPL-102H
Product Overview : Recombinant Human MPL Protein with C-His tag was expressed in E. coli.
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Description : Thrombopoietin receptor (TPOR, c-Mpl) is a hematopoietic receptor that binds the growth factor, thrombopoietin (TPO), responsible for regulation of platelet production. Expression of TPOR by megakaryocytes is required for megakaryocyte growth and development. TPOR is also expressed by hematopoietic stem cells and is required for stem cell maintenance and expansion. Studies show that mice lacking either TPOR or TPO have severely reduced numbers of platelets and megakaryocytes as well as decreased numbers of other hematopoietic lineages. Binding of TPO to TPOR induces receptor dimerization that leads to phosphorylation and activation of the tyrosine kinase Jak2. Activated Jak2 associates with the cytoplasmic domain of TPOR and phosphorylates TPOR at Tyr626 and Tyr631. These phosphorylated tyrosine residues provide docking sites for downstream signaling molecules including Stat3, Stat5, Shc, and SHIP.
Source : E. coli
Species : Human
Tag : C-His
Molecular Mass : ~51 kDa
AA Sequence : QDVSLLASDSEPLKCFSRTFEDLTC FWDEEEAAPSGTYQLLYAYPREKPR ACPLSSQSMPHFGTRYVCQFPDQEE VRLFFPLHLWVKNVFLNQTRTQRVL FVDSVGLPAPPSIIKAMGGSQPGEL QISWEEPAPEISDFLRYELRYGPRD PKNSTGPTVIQLIATETCCPALQRP HSASALDQSPCAQPTMPWQDGPKQT SPSREASALTAEGGSCLISGLQPGN SYWLQLRSEPDGISLGGSWGSWSLP VTVDLPGDAVALGLQCFTLDLKNVT CQWQQQDHASSQGFFYHSRARCCPR DRYPIWENCEEEEKTNPGLQTPQFS RCHFKSRNDSIIHILVEVTTAPGTV HSYLGSPFWIHQAVRLPTPNLHWRE ISSGHLELEWQHPSSWAAQETCYQL RYTGEGHQDWKVLEPPLGARGGTLE LRPRSRYRLQLRARLNGPTYQGPWS SWSDPTRVETATETAW
Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Notes : For research use only, not for use in diagnostic procedure.
Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
Concentration : ≥0.5 mg/mL
Storage Buffer : PBS, 4M Urea, pH7.4
Gene Name : MPL myeloproliferative leukemia virus oncogene [ Homo sapiens (human) ]
Official Symbol : MPL
Synonyms : MPL; myeloproliferative leukemia virus oncogene; thrombopoietin receptor; CD110; TPOR; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; MPLV; C-MPL; THCYT2;
Gene ID : 4352
mRNA Refseq : NM_005373
Protein Refseq : NP_005364
MIM : 159530
UniProt ID : P40238

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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