MTHFD2
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Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
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Overview
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. -
Synonyms
MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NAD-dependent methylene tetrahydrofolate dehydrogenase cycloh;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
MTHFD2 involved in several pathways and played different roles in them. We selected most pathways MTHFD2 participated on our site, such as Metabolic pathways, Nucleotide Metabolism, One Carbon Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALDH2.2;PAICS;P4HA3;GOT2B;B3GNT2;AMY1B;PKM2;PTGES3A;FUT2 |
| Nucleotide Metabolism | ADSL;ADSS;MTHFD2;OAZ1 |
| One Carbon Metabolism | MTFMT;AHCY;MTHFD2;FTCD;ALDH1L1;MTHFS;ST20-MTHFS |
| One carbon pool by folate | MTR;MTHFS;ST20-MTHFS;SHMT1;GART;ALDH1L2;MTHFD1B;MTHFD1L;ATIC |
| Trans-sulfuration and one carbon metabolism | DNMT3L;MTHFD2 |
| folate transformations I | ALDH1L2;ALDH1L1;MTHFSD;MTHFD2 |
MTHFD2 has several biochemical functions, for example, NOT formate-tetrahydrofolate ligase activity, magnesium ion binding, methenyltetrahydrofolate cyclohydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD2 itself. We selected most functions MTHFD2 had, and list some proteins which have the same functions with MTHFD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT formate-tetrahydrofolate ligase activity | MTHFD2;MTHFD2L |
| magnesium ion binding | PIF1;PKMB;ENOSF1;CDC42BPA;PPA1B;ZNF143B;NUDT5;FAN1;AASDHPPT |
| methenyltetrahydrofolate cyclohydrolase activity | MTHFD1;MTHFD1B;MTHFD2L;MTHFD2 |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | MTHFD2L;MTHFD2;MTHFD1 |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | MTHFD1B;MTHFD2;MTHFD1;MTHFD2L |
| phosphate ion binding | G6PC;SH2B3;ADSS;RPH3A;ADSSL1;CHST14;RELA;MTHFD2;PNP |
MTHFD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFD2.
MCC; PSMD13; PARP3; NAGK; Nek2; nef; Lmna; LRRK2; P
- Q&As
- Reviews
Q&As (5)
Ask a questionMTHFD2 is involved in the mitochondrial folate pathway, influencing the synthesis of nucleotides and methionine.
Some clinical trials are exploring the efficacy of MTHFD2 inhibitors in cancer treatment.
MTHFD2 expression is often dysregulated in cancer and other metabolic disorders.
Research is ongoing to develop inhibitors that selectively target MTHFD2, showing promise for cancer treatment.
Elevated MTHFD2 levels have been observed in certain cancers, suggesting its potential as a diagnostic marker.
Customer Reviews (3)
Write a reviewIt can also be employed in various molecular biology techniques, such as Western blotting, immunoprecipitation, or protein-protein interaction studies.
Its versatility allows researchers to explore MTHFD2's involvement in diverse biological processes and fully uncover its functional role.
the MTHFD2 protein's high quality, dependable performance, and comprehensive technical support make it an excellent choice for researchers seeking to investigate angiopoietin-related biology and unravel the complexities of vascular development and pathogenesis.
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