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Official Full Name myosin, light chain 12A, regulatory, non-sarcomeric
Background Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain,;such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments;(Iwasaki et al., 2001 (PubMed 11942626)).
Synonyms MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric; myosin, light polypeptide, regulatory, non sarcomeric (20kD); myosin regulatory light chain 12A; MLCB; MRCL3; MRLC3; MYL2B; myosin regulatory light chain 3; nonsarcomeric; RLC; ML12A_HUMAN; MLC 2B; MLC-2B; Myosin regulatory light chain 2; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRCL3; Myosin regulatory light chain MRLC3; Myosin RLC; OTTHUMP00000162243; myosin, light polypeptide, regula
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MYL12A-4844H Recombinant Human MYL12A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MYL12A-28634TH Recombinant Human MYL12A, His-tagged E.coli His
    Human MYL12A-3606H Recombinant Human MYL12A, His-tagged E.coli His
    Human MYL12A-4030HCL Recombinant Human MYL12A 293 Cell Lysate HEK293 N/A
    Human MYL12A-5458H Recombinant Human Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric E.coli N/A
    Human MYL12A-5536H Recombinant Human MYL12A Protein, His-tagged E.coli His
    Rat MYL12A-3852R Recombinant Rat MYL12A Protein Mammalian Cell His
    Rhesus Macaque MYL12A-2921R Recombinant Rhesus monkey MYL12A Protein, His-tagged Mammalian Cell His
    Chicken MYL12A-6893C Recombinant Chicken MYL12A Mammalian Cell His

    myl12a involved in several pathways and played different roles in them. We selected most pathways myl12a participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with myl12a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance ADAM10; SEMA3D; NFATC3; DPYSL5A; AP2S1; PHB; SPRED1; COL6A3; SEMA4C; PPP3CA
    Developmental Biology CACNG2B; PAQR3A; TCF4; RASGRP4; EFNB3; FOXD3; DPYSL5A; MED8; FRS2A; EPHA2
    Ephrin signaling EPHB4B; EPHB4A; MYL12A; EPHB3A; EFNB2; SDCBP; EFNB1; EFNB3B; EFNB2A; EFNB3
    Focal adhesion MYLPF; SHC3; PIK3R3A; VAV2; COL2A1B; BADB; MYLPFA; THBS1; COL24A1; FLNC
    Leukocyte transendothelial migration RAP1A; ITGA4; CLDN9; CLDN3; ACTB; PIK3CD; OCLN; PXN; ACTN2; ACTN1
    Muscle contraction TCAP; DMD; TRIM72; SMYHC3; TNNI1; TMOD1; DES; TNNT3; MYL6B; TMOD2
    Platelet activation ARHGEF1; PIK3R5; AKT2; COL27A1; MYL12A; ITGB1; VWF; PLCG2; PIK3R2; FERMT3

    myl12a has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by myl12a itself. We selected most functions myl12a had, and list some proteins which have the same functions with myl12a. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CRNN; PCDHGB3; MMP14B; ENPP2; ANXA3B; KCNIP3B; PVALB3; PCDHB15; CALM; PLCH2
    protein binding CDC14B; CIB3; C5orf20; FLCN; ECH1; SMAD3A; PLUNC; MED23; SOCS2; STRADA

    myl12a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with myl12a here. Most of them are supplied by our site. Hope this information will be useful for your research of myl12a.

    IKBKE; GRB2; CIT; Cdc42bpa; PAK1; MYLK; CDC42BPA; Rock2; Cdc42bpb; CHUK; EIF1B; TNFRSF1A; MCC; VHL; ACTB; MAP3K3; TNIK

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