NF1
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Official Full Name
neurofibromin 1
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Synonyms
NF1; neurofibromin 1; neurofibromin; neurofibromatosis; von Recklinghausen disease; Watson disease; neurofibromatosis-related protein NF-1; WSS; NFNS; VRNF; FLJ21220; DKFZp686J1293;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Baculovirus-Insect Cells
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- Strep
- N
- C
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NF1-334H | Recombinant Human NF1 Protein, His-tagged | E.coli | His | ||
| Human | NF1-335H | Recombinant Human NF1, GST-tagged | Wheat Germ | GST |
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| Human | NF1-32H | Active Recombinant Human NF1 Protein (1197-1528), N-His tagged | E.coli | His | 1197-1528 |
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| Human | NF1-2983H | Recombinant Human NF1 protein(1566-1837aa), His&Myc-tagged | E. coli | N-His&C-Myc | 1566-1837aa |
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| Human | NF1-01HFL | Recombinant Full Length Human NF1 Protein, His&Strep-tagged | Baculovirus-Insect Cells | His&Strep |
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| Rat | NF1-3967R | Recombinant Rat NF1 Protein | Mammalian Cell | His |
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| Rat | NF1-3625R-B | Recombinant Rat NF1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | NF1-3625R | Recombinant Rat NF1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Chicken | NF1-643C | Recombinant Chicken NF1 protein, His&Myc-tagged | E.coli | His&Myc | 1-270a.a. |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
NF1 involved in several pathways and played different roles in them. We selected most pathways NF1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RRAS2;PPM1NB;HSPB1;NLK;MAP2K2;FAS;HRASA;PAK2;FGF20B |
| Ras signaling pathway | ARF6;GNB2;MLLT4;FGF8;RELA;INSR;PLD1;FOXO4;PTPN11 |
NF1 has several biochemical functions, for example, GTPase activator activity, phosphatidylcholine binding, phosphatidylethanolamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NF1 itself. We selected most functions NF1 had, and list some proteins which have the same functions with NF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP5;TBC1D24;ECT2;RAP1GDS1;DEPDC1;ELMOD1;SGSM3;STARD13;GNAQ |
| phosphatidylcholine binding | CETP;ALDOB;CHMP2A;APOA4A;ESYT2;VPS24;APOA5;NF1;APOA1A |
| phosphatidylethanolamine binding | ESYT2;ANXA11;LC3;CD300A;NF1;MFGE8;PEBP1;PEMT |
| protein binding | KIAA1737;CTDNEP1;ACKR4;NRCAM;BLNK;PLD2;GSK3B;PEX11B;USP4 |
NF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NF1.
APP; PML; SUMO1; DYNC1H1; Sdc1; Sdc3; SDC2; Sdc2; Sdc4; pi3p
Research Area
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Q&As (7)
Ask a questionThe NF1 gene encodes neurofibromin, a protein primarily known for its role as a tumor suppressor. It regulates cell growth and differentiation.
Mutations in the NF1 gene can lead to a loss of neurofibromin function, resulting in uncontrolled RAS activation and increased cell proliferation, contributing to tumorigenesis.
Neurofibromin, the product of the NF1 gene, acts as a GTPase-activating protein (GAP) for RAS, accelerating the conversion of active RAS-GTP to its inactive form RAS-GDP, thereby negatively regulating the RAS/MAPK pathway.
NF1 interacts with several proteins in cellular pathways, including c-Raf, mTOR, and adenylate cyclase. Its dysregulation can influence the activity of these proteins and associated pathways.
By regulating the RAS/MAPK pathway, NF1 plays a crucial role in controlling cell growth, differentiation, and apoptosis.
Current therapeutic strategies for NF1-related disorders include surgical removal of tumors, targeted therapies like MEK inhibitors for plexiform neurofibromas, and regular monitoring for associated complications.
Neurofibromatosis Type 1 is characterized by multiple café-au-lait spots, skinfold freckling, neurofibromas, optic pathway gliomas, and certain bone abnormalities, among other manifestations.
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