NPC2
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Official Full Name
Niemann-Pick disease, type C2
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Overview
This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008] -
Synonyms
NPC2; Niemann-Pick disease, type C2; HE1; EDDM1; epididymal secretory protein E1; epididymal protein 1; tissue-specific secretory protein; human epididymis-specific protein 1; Niemann-Pick disease type C2 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dog
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NPC2 Related Articles
NPC2 involved in several pathways and played different roles in them. We selected most pathways NPC2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | NPC2;AP1S2;GNS;DNASE2A;ARSA;GM2A;ATP6V0D2;DNASE2B;CTSSB.1 |
NPC2 has several biochemical functions, for example, cholesterol binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPC2 itself. We selected most functions NPC2 had, and list some proteins which have the same functions with NPC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol binding | CYP11A1;APOEB;APOA1A;APOA4B.2;ERLIN2;PROM2;APOA1;APOC3;SOAT1 |
| enzyme binding | BLZF1;CYB5A;DHCR24;LUC7L2;NLRP1;PTPN1;MAPK14;ITGB3;PPP3CB |
| protein binding | UBTD1;HACE1;RQCD1;PCSK5;RERG;FAM115A;ITPR1;PPP1R13L;PYCARD |
NPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPC2.
cholesterol; q81tt5_bacan
- Q&As
- Reviews
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