NPPA
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Official Full Name
natriuretic peptide A -
Overview
Atrial natriuretic peptide (ANP), atrial natriuretic factor (ANF), atrial natriuretic hormone (ANH), or atriopeptin, is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. -
Synonyms
Nppa;natriuretic peptide precursor A;ANF;ANP;Pnd;RATANF;natriuretic peptides A;prepronatriodilatin;atrial natriuretic factor;atrial natriuretic peptide;natriuretic peptide precursor type A;Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd);Auriculin-B;Auriculin-A;Atriopeptin-1;Atriopeptin I;Atriopeptin-2;Atriopeptin II;Atriopeptin-3;Atriopeptin IIIy
Recombinant Proteins
- Human
- Mouse
- Cattle
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- T7
- Non
- KSI
- Avi
- Fc
Involved Pathway
NPPA involved in several pathways and played different roles in them. We selected most pathways NPPA participated on our site, such as HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | AKT1,MKNK1,EGLN1,FLT1,CUL2,INS1,CAMK2G,IGF1,PDHA2,STAT3 |
Protein Function
NPPA has several biochemical functions, for example, neuropeptide hormone activity,neuropeptide receptor binding,peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPPA itself. We selected most functions NPPA had, and list some proteins which have the same functions with NPPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | PTK2AA,CXCL1,ARPP19A,ACOX1,SRI,RCHY1,NRG2B,WNT4B,FGF11A,CADM2 |
| neuropeptide hormone activity | PENK,PYY,C12orf39,NTS,CALCB,HCRT,CRH,ADCYAP1,POMCA,CCK |
| peptide hormone receptor binding | PTHLH,PTH,NPPC,FYN,LEP,JAK2,ADCYAP1,PTHLHA,PTPN11,RUNDC3A |
| protein binding | ZBTB2,TNIP2,PRKAG1,TRPC5,C5orf20,GGA3,DENR,ZBTB7B,UBE2E3,CALML3 |
Interacting Protein
NPPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPPA here. Most of them are supplied by our site. Hope this information will be useful for your research of NPPA.
MAGEA12;UBQLN1;UBQLN4
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References
- Pereira, NL; Tosakulwong, N; et al. Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated With Stroke in Whites. CIRCULATION-CARDIOVASCULAR GENETICS 8:141-U292(2015).
- Ovchinnikov, DA; Hidalgo, A; et al. Isolation of Contractile Cardiomyocytes from Human Pluripotent Stem-Cell-Derived Cardiomyogenic Cultures Using a Human NCX1-EGFP Reporter. STEM CELLS AND DEVELOPMENT 24:11-20(2015).
