Nqo1
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Official Full Name
NAD(P)H dehydrogenase, quinone 1
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Overview
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
NQO1; NAD(P)H dehydrogenase, quinone 1; DTD; QR1; DHQU; DIA4; NMOR1; NMORI; NAD(P)H dehydrogenase [quinone] 1; azoreductase; diaphorase-4; DT-diaphorase; dioxin-inducible 1; menadione reductase; quinone reductase 1; phylloquinone reductase; NAD(P)H:quinone oxireductase; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; diaphorase (NADH/NADPH) (cytochrome b-5 reductase);
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- Interacting Protein
- Nqo1 Related Articles
- Nqo1 Related Research Area
Nqo1 involved in several pathways and played different roles in them. We selected most pathways Nqo1 participated on our site, such as AhR pathway, Dopamine metabolism, Estrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Nqo1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AhR pathway | FLG;NQO1;EGFR;CYP1A1;CYP1B1;JUN;CYP1A2;AIP;JUND |
Dopamine metabolism | COMT;NQO1;DDC |
Estrogen metabolism | NQO1;COMT;ARSD;ARSE;CYP1A1;CYP1B1 |
Keap1-Nrf2 Pathway | AIMP2;NQO1 |
Metabolism | ATP5S;HPSE;SLC16A1;OXSR1;NAMPT;CYP2F1;ADHFE1;HIBADHA;MARCKSA |
Metabolism of amino acids and derivatives | ALDH9A1A.2;NAALAD2;DAO1;AFMID;BCKDK;NQO1;DAO;AHCY;SLC25A10 |
Metabolism of polyamines | SLC25A15;SLC6A8;SLC6A12;SLC6A7;PAOX;CKB;NQO1;OAZ1A;CKMT2A |
Oxidative Stress | TXN2;JUNBA;TXNRD2;NOX4;NFIX;NQO1 |
Nqo1 has several biochemical functions, for example, NAD(P)H dehydrogenase (quinone) activity, cytochrome-b5 reductase activity, acting on NAD(P)H, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Nqo1 itself. We selected most functions Nqo1 had, and list some proteins which have the same functions with Nqo1. You can find most of the proteins on our site.
Function | Related Protein |
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NAD(P)H dehydrogenase (quinone) activity | NQO1;CBR4 |
cytochrome-b5 reductase activity, acting on NAD(P)H | CYB5R3;CYB5R2;CYB5R4;CYB5RL;CYB5R1;NQO1;POR |
identical protein binding | S100A1;PPP1R13L;VWF;AKT1;ZNF212;G6PD;EDC3;LECT2;LRP6 |
poly(A) RNA binding | MRPS9;ALDOA;CSDA;RBM28;DHX35;SRSF5;ZMAT3;PPIE;PUM1 |
protein binding | CHN2;NF1;RPL14;CD1d1;FAM184A;KRTAP3-3;NUFIP1;C1orf94;MARVELD2 |
superoxide dismutase activity | SOD3A;SOD1;NQO1;PRNPA;CCS;SOD2 |
Nqo1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nqo1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Nqo1.
ING1; Tp63; Tp63; NDUFS7; VCAM1
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Q&As (6)
Ask a questionMutations in NQO1 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
The types of mutations in NQO1 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.
Abnormal NQO1 levels may indicate cancer, neurodegenerative diseases, and oxidative stress-related diseases.
Studying the regulatory mechanism of NQO1 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
This protein can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting NQO1, such as gene therapy or modulating its expression, are also being studied.
NQO1 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
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