Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Nqo1

  • Official Full Name

    NAD(P)H dehydrogenase, quinone 1

  • Overview

    This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    NQO1; NAD(P)H dehydrogenase, quinone 1; DTD; QR1; DHQU; DIA4; NMOR1; NMORI; NAD(P)H dehydrogenase [quinone] 1; azoreductase; diaphorase-4; DT-diaphorase; dioxin-inducible 1; menadione reductase; quinone reductase 1; phylloquinone reductase; NAD(P)H:quinone oxireductase; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; diaphorase (NADH/NADPH) (cytochrome b-5 reductase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NQO1-1352H Recombinant Human NQO1, GST-tagged E.coli GST 1-274aa
Human NQO1-377H Recombinant Human NAD(P)H Dehydrogenase, Quinone 1 E.coli N/A
Human NQO1-29158TH Recombinant Human NQO1, His-tagged E.coli His
Human NQO1-136H Recombinant Human NQO1 Protein E.coli N/A 1-274
Human NQO1-197H Recombinant Human NQO1 Mammalian Cell His
Human NQO1-1393H Recombinant Human NAD(P)H Dehydrogenase, Quinone 1, His-tagged Human His
Human NQO1-138H Recombinant Human NQO1 protein, His-tagged E.coli His Met1-Lys274
Human NQO1-3725HCL Recombinant Human NQO1 293 Cell Lysate HEK293 N/A
Human NQO1-1534H Recombinant Human NQO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NQO1-1534H-B Recombinant Human NQO1 Protein Pre-coupled Magnetic Beads HEK293
Human NQO1-6062H Recombinant Human NQO1 Protein, GST-tagged Wheat Germ GST
Human NQO1-001H Active Recombinant Human NQO1 Protein E. coli N/A
Human NQO1-4163H Recombinant Human NQO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NQO1-6683HF Recombinant Full Length Human NQO1 Protein, GST-tagged In Vitro Cell Free System GST 274 amino acids
Human NQO1-1607HFL Recombinant Full Length Human NQO1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Nqo1-4512M Recombinant Mouse Nqo1 protein, His-SUMO-tagged E.coli His-SUMO 2-274aa
Mouse Nqo1-1919M Recombinant Mouse Nqo1 protein, His & T7-tagged E.coli His/T7 Ala2~Lys274 (Accession # Q64669)
Mouse Nqo1-5780M Recombinant Mouse Nqo1 protein, His-tagged Yeast His 2-274aa
Mouse Nqo1-4482M Recombinant Mouse Nqo1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Nqo1-721R Recombinant Rat NAD(P)H Dehydrogenase, Quinone 1 E.coli N/A
Rat Nqo1-723R Recombinant Rat Nqo1 protein, His/sumo-tagged E.coli His/SUMO 2-274 aa
Rat Nqo1-722R Recombinant Rat Nqo1 E.coli N/A
Rat NQO1-4058R Recombinant Rat NQO1 Protein Mammalian Cell His
Rat NQO1-3717R Recombinant Rat NQO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NQO1-3717R-B Recombinant Rat NQO1 Protein Pre-coupled Magnetic Beads HEK293
Rat Nqo1-1920R Recombinant Rat Nqo1 protein, His & T7-tagged E.coli His/T7 Ala2~Arg273 (Accession # P05982)
Rhesus Macaque NQO1-3090R Recombinant Rhesus monkey NQO1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NQO1-2909R-B Recombinant Rhesus Macaque NQO1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NQO1-2909R Recombinant Rhesus Macaque NQO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NQO1-8015Z Recombinant Zebrafish NQO1 Mammalian Cell His
Chicken NQO1-4998C Recombinant Chicken NQO1 Mammalian Cell His
Kit-0633 NQO1 Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Nqo1 Related Articles
  • Nqo1 Related Research Area

Nqo1 involved in several pathways and played different roles in them. We selected most pathways Nqo1 participated on our site, such as AhR pathway, Dopamine metabolism, Estrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Nqo1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AhR pathwayFLG;NQO1;EGFR;CYP1A1;CYP1B1;JUN;CYP1A2;AIP;JUND
Dopamine metabolismCOMT;NQO1;DDC
Estrogen metabolismNQO1;COMT;ARSD;ARSE;CYP1A1;CYP1B1
Keap1-Nrf2 PathwayAIMP2;NQO1
MetabolismATP5S;HPSE;SLC16A1;OXSR1;NAMPT;CYP2F1;ADHFE1;HIBADHA;MARCKSA
Metabolism of amino acids and derivativesALDH9A1A.2;NAALAD2;DAO1;AFMID;BCKDK;NQO1;DAO;AHCY;SLC25A10
Metabolism of polyaminesSLC25A15;SLC6A8;SLC6A12;SLC6A7;PAOX;CKB;NQO1;OAZ1A;CKMT2A
Oxidative StressTXN2;JUNBA;TXNRD2;NOX4;NFIX;NQO1

Nqo1 has several biochemical functions, for example, NAD(P)H dehydrogenase (quinone) activity, cytochrome-b5 reductase activity, acting on NAD(P)H, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Nqo1 itself. We selected most functions Nqo1 had, and list some proteins which have the same functions with Nqo1. You can find most of the proteins on our site.

Function Related Protein
NAD(P)H dehydrogenase (quinone) activityNQO1;CBR4
cytochrome-b5 reductase activity, acting on NAD(P)HCYB5R3;CYB5R2;CYB5R4;CYB5RL;CYB5R1;NQO1;POR
identical protein bindingS100A1;PPP1R13L;VWF;AKT1;ZNF212;G6PD;EDC3;LECT2;LRP6
poly(A) RNA bindingMRPS9;ALDOA;CSDA;RBM28;DHX35;SRSF5;ZMAT3;PPIE;PUM1
protein bindingCHN2;NF1;RPL14;CD1d1;FAM184A;KRTAP3-3;NUFIP1;C1orf94;MARVELD2
superoxide dismutase activitySOD3A;SOD1;NQO1;PRNPA;CCS;SOD2

Nqo1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nqo1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Nqo1.

ING1; Tp63; Tp63; NDUFS7; VCAM1

Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
Kim, H; Rigell, CJ; et al. Antagonistic Effects of Anti-EMMPRIN Antibody When Combined with Chemotherapy Against Hypovascular Pancreatic Cancers. MOLECULAR IMAGING AND BIOLOGY 16:85-94(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How are mutations in NQO1 detected and analyzed? 10/12/2022

Mutations in NQO1 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What are the mutation types of NQO1? 12/23/2021

The types of mutations in NQO1 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.

Are abnormal NQO1 levels indicative of a disease? 02/04/2021

Abnormal NQO1 levels may indicate cancer, neurodegenerative diseases, and oxidative stress-related diseases.

How to study the regulatory mechanism of NQO1? 06/07/2020

Studying the regulatory mechanism of NQO1 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What are the applications of NQO1 in medical treatment? 02/25/2020

This protein can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting NQO1, such as gene therapy or modulating its expression, are also being studied.

Is there a relationship between NQO1 and other genes or proteins? 02/18/2020

NQO1 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

Customer Reviews (0)

Write a review

Ask a Question for All Nqo1 Products

Required fields are marked with *

My Review for All Nqo1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends