NTRK2

  • Official Full Name

    neurotrophic tyrosine kinase, receptor, type 2

  • Overview

    This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    NTRK2; neurotrophic tyrosine kinase, receptor, type 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; trkB tyrosine kinase; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B; neurotrophic tyrosine receptor kinase type 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Chicken
  • Dog
  • Human
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • His
  • DDK
  • DDK|His
  • Fc
  • Fc|His
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NTRK2-109H Active Recombinant Human NTRK2, Fc Chimera HEK293 Fc
Human NTRK2-249H Active Recombinant Human NTRK2(455-end) Protein, N-His-tagged Sf21 His 455-end
Human NTRK2-158H Recombinant Human NTRK2, Fc-His tagged Human Cell Fc/His
Human NTRK2-157H Active Recombinant Human NTRK2 protein, His-tagged HEK293 His Met 1-His430
Human NTRK2-31620TH Recombinant Human NTRK2 N/A
Human NTRK2-496H Recombinant Human Neurotrophic Tyrosine Kinase, Receptor, Type 2 Mammalian cells N/A
Human NTRK2-718H Recombinant Human NTRK2, GST-His Sf9 Insect Cell GST
Human NTRK2-31621TH Recombinant Human NTRK2, Fc-tagged Fc
Human NTRK2-87H Recombinant Human NTRK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human NTRK2-449H Recombinant Human NTRK2, GST-tagged, Active Sf9 Insect Cell GST
Human NTRK2-159H Recombinant Human NTRK2 protein, Fc-tagged HEK293 human/IgG1/Fc 399
Human NTRK2-752H Recombinant Human NTRK2 Protein, DDK-tagged Sf9 Insect Cell DDK
Human NTRK2-751H Recombinant Human NTRK2 Protein, DDK/His-tagged HEK293 DDK/His
Human NTRK2-2683HCL Recombinant Human NTRK2 cell lysate Human Cell N/A
Human NTRK2-379H Recombinant Human NTRK2 Protein, His-tagged E.coli His Cys32~His430
Human NTRK2-158HAF555 Recombinant Human NTRK2 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 646
Human NTRK2-158HAF488 Recombinant Human NTRK2 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 646
Human NTRK2-4731H Recombinant Human NTRK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NTRK2-3889H Recombinant Human NTRK2 protein, His-tagged E.coli His 41-433 aa
Human NTRK2-157HAF647 Recombinant Human NTRK2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Cys32-His430
Human NTRK2-157HAF555 Recombinant Human NTRK2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Cys32-His430
Human NTRK2-4467H Recombinant Human NTRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NTRK2-157HAF488 Recombinant Human NTRK2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Cys32-His430
Human NTRK2-157HF Recombinant Human NTRK2 Protein, His-tagged, FITC conjugated HEK293 His Cys32-His430
Human NTRK2-158HF Recombinant Human NTRK2 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 646
Human NTRK2-2617H Recombinant Human NTRK2 Protein (Cys32-His430), His tagged E.coli His Cys32-His430
Human NTRK2-4467H-B Recombinant Human NTRK2 Protein Pre-coupled Magnetic Beads HEK293
Human NTRK2-469H Recombinant Human NTRK2 Protein, His-tagged HEK293 His 822
Human NTRK2-1150HFL Recombinant Full Length Human NTRK2 Protein, C-Flag-tagged Mammalian cells Flag
Human NTRK2-24H Recombinant Human NTRK2 Protein (32-430aa), C-His tagged Insect Cell C-His 32-430aa
Human NTRK2-470H Recombinant Human NTRK2 Protein, Fc-tagged HEK293 Fc 822
Human NTRK2-0749H Recombinant Human NTRK2 protein, Fc-tagged HEK293 Fc Cys32-His430
Human NTRK2-158HAF647 Recombinant Human NTRK2 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 646
Human NTRK2-4744H Recombinant Human NTRK2 Protein (Cys32-His430), C-His tagged Mammalian cells C-His Cys32-His430
Mouse Ntrk2-359M Recombinant Mouse Ntrk2 Protein, His-tagged Insect Cell His
Mouse NTRK2-1843MCL Recombinant Mouse NTRK2 cell lysate Human Cell N/A
Mouse Ntrk2-1353MAF555 Recombinant Mouse Ntrk2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 409
Mouse Ntrk2-1353MAF488 Recombinant Mouse Ntrk2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 409
Mouse Ntrk2-4523M Recombinant Mouse Ntrk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ntrk2-7290M Recombinant Mouse Ntrk2 Protein, His-tagged Insect Cell His 32-429
Mouse Ntrk2-1353MAF647 Recombinant Mouse Ntrk2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 409
Mouse Ntrk2-1353MF Recombinant Mouse Ntrk2 Protein, His-tagged, FITC conjugated HEK293 His 409
Rat NTRK2-1095R Active Recombinant Rat NTRK2 Protein, His-tagged HEK293 His
Rat NTRK2-1095RF Active Recombinant Rat NTRK2 Protein, His-tagged, FITC conjugated HEK293 His 409
Rat NTRK2-1095RAF488 Active Recombinant Rat NTRK2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 409
Rat NTRK2-1095RAF647 Active Recombinant Rat NTRK2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 409
Rat NTRK2-1095RAF555 Active Recombinant Rat NTRK2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 409
Rat NTRK2-4103R Recombinant Rat NTRK2 Protein Mammalian Cell His
Rat Ntrk2-7471R Recombinant Rat Ntrk2 protein, hFc-tagged HEK293 hFc Met1-His429
Rat NTRK2-1300RCL Recombinant Rat NTRK2 cell lysate Human Cell N/A
Rat Ntrk2-7471RAF488 Recombinant Rat Ntrk2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 639
Rat Ntrk2-7471RAF555 Recombinant Rat Ntrk2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 639
Rat Ntrk2-7471RF Recombinant Rat Ntrk2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 639
Rat NTRK2-3764R Recombinant Rat NTRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ntrk2-7471RAF647 Recombinant Rat Ntrk2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 639
Rat NTRK2-3764R-B Recombinant Rat NTRK2 Protein Pre-coupled Magnetic Beads HEK293
Dog NTRK2-1041CAF488 Recombinant Canine NTRK2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 640
Dog NTRK2-1041CAF555 Recombinant Canine NTRK2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 640
Dog NTRK2-1041CAF647 Recombinant Canine NTRK2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 640
Dog NTRK2-1041CF Recombinant Canine NTRK2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 640
Canine NTRK2-1041C Recombinant Canine NTRK2 Protein, Fc-tagged HEK293 Fc
Canine NTRK2-1024CCL Recombinant Canine NTRK2 cell lysate Human Cell N/A
Canine NTRK2-1091C Active Recombinant Canine NTRK2 protein, His-tagged HEK293 His Met1-His430
Mus musculus (Mouse) RFL36710MF Recombinant Full Length Mouse Bdnf/Nt-3 Growth Factors Receptor(Ntrk2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (32-821)
Rhesus Macaque NTRK2-3118R Recombinant Rhesus monkey NTRK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NTRK2-2937R Recombinant Rhesus Macaque NTRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NTRK2-2937R-B Recombinant Rhesus Macaque NTRK2 Protein Pre-coupled Magnetic Beads HEK293
Chicken NTRK2-6784C Recombinant Chicken NTRK2 Mammalian Cell His
Kit-1547 U2OS TrkB Bioassay Kit N/A
Kit-1629 TrkB Functional Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

NTRK2 involved in several pathways and played different roles in them. We selected most pathways NTRK2 participated on our site, such as MAPK signaling pathway, Neurotrophin signaling pathway, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNG4;RPS6KA3;SRF;AKT3A;PPM1BB;CACNG8;RAF1;MOS;MAPK8
Neurotrophin signaling pathwayPLCG1;MAPK3;PLCG2;MAP2K7;NGFR;ATF4;RAPGEF1;CALM3;PIK3CD
AlcoholismHDAC3;H3F3A;HRAS;HDAC10;HIST4H4;SOS1;H2AFY2;GNB2;HIST2H3A

NTRK2 has several biochemical functions, for example, ATP binding, brain-derived neurotrophic factor binding, brain-derived neurotrophic factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK2 itself. We selected most functions NTRK2 had, and list some proteins which have the same functions with NTRK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRP1;DDX28;CAMKK1;EEF2K;SMARCA5;MYH15;MAP2K4;FANCM;RAD54L
brain-derived neurotrophic factor binding
brain-derived neurotrophic factor-activated receptor activity
neurotrophin bindingNTRK2;NTRK3;NTRK1;NGFR
protein homodimerization activityGSTM7;OLIG2;PDGFB;UGT1A1;IRAK3;TYW5;ATPIF1;Il6ra;SH3GLB1

NTRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK2.

saicar; PKM; SORT1; abl-tide; HSP90AB1; NTF4; EGFR; POLR2G; AP1B1; NMNAT1

Research Area

Related articles

Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
Wessels, JM; Wu, L; et al. The Brain-Uterus Connection: Brain Derived Neurotrophic Factor (BDNF) and Its Receptor (Ntrk2) Are Conserved in the Mammalian Uterus. PLOS ONE 9:-(2014).
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