pak2 Protein, p21 protein (Cdc42/Rac)-activated kinase 2


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Official Full Name p21 protein (Cdc42/Rac)-activated kinase 2
Background Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Synonyms p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; PAK2; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC; PAK-2; Gamma-PAK; p58
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAK2-1276HCL Recombinant Human PAK2 cell lysate N/A
    Human PAK2-1282H Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 2, GST-tagged Insect Cell GST
    Human PAK2-30670TH Recombinant Human PAK2 E.coli N/A
    Human PAK2-521H Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 2 E.coli N/A
    Human PAK2-721H Recombinant Human PAK2, GST-His Sf9 Insect Cell GST
    Human PAK2-767H Recombinant Human PAK2 Protein, His-tagged E.coli His
    Mouse PAK2-12319M Recombinant Mouse PAK2 Protein Mammalian Cell His
    Rat PAK2-4260R Recombinant Rat PAK2 Protein Mammalian Cell His
    Rhesus Macaque PAK2-3291R Recombinant Rhesus monkey PAK2 Protein, His-tagged Mammalian Cell His

    pak2 involved in several pathways and played different roles in them. We selected most pathways pak2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with pak2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway SHC4; NRG2; PAK6; PAK2; AREGB; AREG; CDKN1BA; MAPK8; HRASB; PIK3CA
    Ras signaling pathway PRKACA; ZAP70; INS2; GRIN1; IKBKB; PLA1A; NRAS; ARF6; RASGRF2; VEGFB
    Axon guidance PPP3R1; EPHB1; RAC2; CLTC; DNM2; EPHA5; CLTB; PLXNA3; FGF8B; GFRA2
    Focal adhesion RHOAA; SHC4; LAMB2; PDGFB; TNN; ITGB3; MAPK6; ITGA3; RAP1A; LAMB1A
    T cell receptor signaling pathway PPP3R2; MAPK13; PIK3R1; CD8B1; PIK3R2; PAK2; VAV3; PLCG1; IKBKB; RAF1
    Regulation of actin cytoskeleton ROCK1; ARAF; ITGA6; FGF22; FGF4; ITGAV; EZRB; GNG12A; WASLB; ARPC5LA
    Renal cell carcinoma ETS1; TCEB2; PIK3CG; CDC42; HRAS; NRAS; PIK3CB; FH1; AHA-1; CUL2

    pak2 has several biochemical functions, for example, ATP binding, Rac GTPase binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pak2 itself. We selected most functions pak2 had, and list some proteins which have the same functions with pak2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NAV3; ATP9A; RAD54B; ATP13A3; IP6K3; PKM2; PTK2AB; TTLL13; PSMC5; FKBP4
    identical protein binding SERPINB1A; CLDN14; SID4; KCNJ10; PYCARD; TTN; C1QTNF2; KIRRELA; CRYAB; PRPF19
    protein binding AIFM1; WHSC1; HBZ; HOXB9; ACPL2; MED12; INPP5K; MAPK1; MEAF6; MCM6
    protein kinase activity PRKCBB; EPHB4B; NEK2; PKZ; TRIOA; SRPK1B; GUCY2F; NPRL2; MAP3K5; MAP3K11
    protein kinase binding MAVS; JAK2; SLC12A7; GSK3B; CCNE1; EPHA1; PPP1R12B; BCAR1; EEF1A2; TRAP1
    protein serine/threonine kinase activity PRKACBB; PRKD1; TP53RK; SNRKA; RPS6KA1; MARK1; SGK2B; MAPK8; SNRK; PBK
    protein tyrosine kinase activator activity ERBB3; ABI1B; GAS6; ABI3A; Cd24a; GHRL; ABI1; NRG1; ABI1A; ERCC6

    pak2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pak2 here. Most of them are supplied by our site. Hope this information will be useful for your research of pak2.


    Lacombe, J; Mange, A; et al. A Multiparametric Serum Marker Panel as a Complementary Test to Mammography for the Diagnosis of Node-Negative Early-Stage Breast Cancer and DCIS in Young Women. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 23:1834-1842(2014).
    Lulf, S; Matz, J; et al. Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. RETROVIROLOGY 11:-(2014).

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