pak2
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  • Official Full Name
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • Background
  • Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
  • Synonyms
  • p21 protein (Cdc42/Rac)-activated kinase 2; PAK65; PAKgamma; PAK2; p21-activated kinase 2; S6/H4 kinase; p21 (CDKN1A)-activated kinase 2; EC 2.7.11.1; PAK-2; Gamma-PAK; p58
Cat.#:PAK2-767HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK2 Protein, His-tagged
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Cat.#:PAK2-521HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 2
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Cat.#:PAK2-721HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK2, GST-His
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Cat.#:PAK2-30670THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK2
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Cat.#:PAK2-12319MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAK2 Protein
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Cat.#:PAK2-4260RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAK2 Protein
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Cat.#:PAK2-3291RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PAK2 Protein, His-tagged
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Cat.#:PAK2-1282HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 2, GST-tagged
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Cat.#:PAK2-1276HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK2 cell lysate
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Involved Pathway

PAK2 involved in several pathways and played different roles in them. We selected most pathways PAK2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RPS6KA1; MAP3K4; RAC2; FGFR1; MAPK7; FGF19; CACNG7A; GRB2A; ARR3A; CACNA1D
ErbB signaling pathway
PTK2AA; HBEGFB; GRB2B; CAMK2B; ABL2; PRKCB; PIK3R1; GSK3AA; CBL; MAP2K2A
Ras signaling pathway
NFKB1; AKT1; PLA2G2F; PRKCB; FGF14; MAPK9; PLD2; GNB3; GNG4; NGFR
Axon guidance
GNAI3; JAK1; SEMA4A; SPNA2; SEMA5A; DLG4; COL9A1A; EPHA7; EFNA3B; ARPC2
Focal adhesion
RAP1B; MAP2K1; MYLK4; TLN2A; GRB2B; DIAP1; ITGB1A; IGF1R; PTK2; ITGA4
T cell receptor signaling pathway
ICOS; NFKBIB; CD3E; CD8B1; PIK3R1; CD3D; VAV1; HRAS; PAK7; PAK6
Regulation of actin cytoskeleton
FGF7; FGF13B; KRAS; PPP1R12B; FGF1A; ITGAL; PAK3; PDGFC; F2R; FGD
Renal cell carcinoma
VHL; KRAS; EP300; GRB2; AHA-1; HIF1A; MAP2K1; ARNT; AKT1; MAPK3

Protein Function

PAK2 has several biochemical functions, for example, ATP binding, Rac GTPase binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK2 itself. We selected most functions PAK2 had, and list some proteins which have the same functions with PAK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UCK2; SYK; UBE2J1; DDX3X; ATP12A; HSPA7; HIPK3; ATP6V1B1; ITPK1A; HIPK1
Function Rac GTPase binding
Related Protein ARHGAP4A; NOX1; PAK2A; DVL1; ARFIP2; SOD1; PAK6; RAB7; PAK4; SRGAP1
Function identical protein binding
Related Protein ERN1; GPR50; CNTN2; MBIP; ST13; DRD4; PYCARD; MMP9; GOT1; RBM10
Function protein binding
Related Protein TXNRD1; SMIM3; PHF19; MYBPC1; MON2; CDKN2A; NEUROG3; RUNX1T1; KCNE2; TPD52L2
Function protein kinase activity
Related Protein MAP3K10; TRIM24; BMPR2A; CDK1; EPHB4B; CAMK2D1; PAK2; CDK11B; RNASEL; EPHA1
Function protein kinase binding
Related Protein CALM1; CNPPD1; FBXO7; NEK9; MAML1; MAG; CASP9; AXIN1; LSM2; STAP1
Function protein serine/threonine kinase activity
Related Protein NEK12; CAMK2D2; VRK1; ADCK4; SGK3; PDPK1; PBK; ROCK2; BMPR1B; MTOR
Function protein tyrosine kinase activator activity
Related Protein GAS6; ERCC6; NRG1; ABI1A; ABI1; AFAP1L2; ABI1B; CD24; Cd24a; ERBB3

Interacting Protein

PAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK2.
RAC1; SORBS3; CDC42; N/A; ARHGEF7

PAK2 Related Articles

Lacombe, J; Mange, A; et al. A Multiparametric Serum Marker Panel as a Complementary Test to Mammography for the Diagnosis of Node-Negative Early-Stage Breast Cancer and DCIS in Young Women. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 23:1834-1842(2014).
Lulf, S; Matz, J; et al. Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. RETROVIROLOGY 11:-(2014).