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PDCD4

  • Official Full Name

    programmed cell death 4 (neoplastic transformation inhibitor)

  • Overview

    This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
  • Synonyms

    PDCD4; programmed cell death 4 (neoplastic transformation inhibitor); H731; programmed cell death protein 4; protein 197/15a; nuclear antigen H731; neoplastic transformation inhibitor protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Rabbit
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDCD4-175H Recombinant Human PDCD4 E.coli N/A
Human PDCD4-30797TH Recombinant Human PDCD4 Wheat Germ N/A 470 amino acids
Human PDCD4-484H Recombinant Human PDCD4 Protein, His-tagged E.coli His
Human PDCD4-1593H Recombinant Human PDCD4, GST-tagged E.coli GST C-term-301aa
Human PDCD4-1320HCL Recombinant Human PDCD4 cell lysate N/A
Human PDCD4-4201H Recombinant Human PDCD4 Protein (Lys212-Pro357), C-His tagged E.coli C-His Lys212-Pro357
Human PDCD4-365HF Active Recombinant Full Length Human PDCD4 Protein In Vitro Cell Free System 470 amino acids
Human CPBT-56409RH Rabbit Anti-Human PDCD4 Polyclonal Antibody Rabbit N/A
Human CPBT-56410RH Rabbit Anti-Human PDCD4 Polyclonal Antibody Rabbit N/A
Mouse PDCD4-12535M Recombinant Mouse PDCD4 Protein Mammalian Cell His
Mouse PDCD4-6574M-B Recombinant Mouse PDCD4 Protein Pre-coupled Magnetic Beads HEK293
Mouse PDCD4-6574M Recombinant Mouse PDCD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDCD4-3341R Recombinant Rhesus monkey PDCD4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDCD4-3159R Recombinant Rhesus Macaque PDCD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDCD4-3159R-B Recombinant Rhesus Macaque PDCD4 Protein Pre-coupled Magnetic Beads HEK293
Chicken PDCD4-5877C Recombinant Chicken PDCD4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDCD4 Related Research Area
  • PDCD4 Related Signal Pathway

PDCD4 involved in several pathways and played different roles in them. We selected most pathways PDCD4 participated on our site, such as Proteoglycans in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteoglycans in cancerCDC42;IL12B;HPSE;PPP1CB;RDX;CTTN;PIK3R1;RPS6KB1;FN1
MicroRNAs in cancerPDGFB;ITGA5;TRP53;TTC6;ZEB1;PDGFRA;STAT3;PIK3CA;MDM4

PDCD4 has several biochemical functions, for example, RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD4 itself. We selected most functions PDCD4 had, and list some proteins which have the same functions with PDCD4. You can find most of the proteins on our site.

Function Related Protein
RNA bindingDROSHA;RBM17;LIN28A;EIF2C3;RNASEN;EIF4EB;PABPN1;HNRNPC;UPF1
protein bindingRIPK3;PMEPA1;SMAGP;WLS;TCEB3;GFM1;FCGR2C;EID3;HSPA14

PDCD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD4.

EIF4A2; EIF4A1; RELA; EIF4A3; RPS13

  • Q&As
  • Reviews

Q&As (6)

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Can PDCD4 be used as a target for sequencing signals? 02/21/2022

Yes, PDCD4 is involved in the regulation of NF-κB signaling pathway and other biological processes of sequencing signals, and can be a target for sequencing signals.

How can changes in the expression and function of PDCD4 be assessed? 11/14/2021

Immunodeficiency method, Western blot, fluorescence microscopy and other techniques can be used to evaluate the changes in the expression and function of PDCD4.

What is the role of PDCD4 in intestinal disease? 07/22/2021

It may be involved in processes such as proliferation, apoptosis, and inflammatory response of intestinal epithelial cells, and is associated with intestinal diseases.

What is the role of PDCD4 in neurological disorders? 12/25/2020

PDCD4 may be related to neuronal apoptosis, neuroinflammatory response, etc. in neurological diseases.

What is the relationship between PDCD4 and liver disease? 08/26/2020

PDCD4 is involved in the regulation of hepatocyte growth, apoptosis and transformation, and may play a role in the occurrence and development of liver diseases.

How can the information from PDCD4 be used for the development of therapeutic strategies? 08/13/2020

Through in-depth study of the signaling pathways and regulatory mechanisms of PDCD4, we can provide important clues for the development of therapeutic strategies for related diseases.

Customer Reviews (3)

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Reviews
04/03/2021

    Good solubility and stability in solution.

    01/27/2021

      The purity is good, and the results obtained after analysis by SDS-PAGE or Western blot are good.

      01/12/2021

        Short half-life and high clearance.

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