Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

Recombinant Human PDCD4

Cat.No. : PDCD4-175H
Product Overview : Recombinant Human programmed cell death 4 (neoplastic transformation inhibitor) protein produced inE.Coliis a single, non-glycosylated polypeptide chain. The protein contains 469 amino acids and has a molecular mass of 51 kDa.
  • Specification
  • Gene Information
  • Related Products
  • Download
Cat. No. : PDCD4-175H
Description : PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein & afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis & cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription.
Source : Escherichia Coli.
Amino Acid Sequence : MDVENEQILN VNPADPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISAYSI NEARINAKAK RRLRKNSSRD SGRGDSVSDS GSDALRSGLT VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ERAFEKTLTP IIQEYFEHGD TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTTDVEKSF DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV LLSMSKGGKR KDSVWGSGGG QQSVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH HELVYEAIIM VLESTGESTF KMILDLLKSL WKSSTITVDQ MKRGYERIYN EIPDINLDVP HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY.
Physical Appearance : Sterile Filtered colorless solution.
Formulation : The protein solution (1mg/ml) cotains 20mM Tris-HCl pH-8, 1mM DTT and 0.1M sodium chloride.
Purity : Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Stability : PDCD4 although stable 14°Cfor 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Tag : Non
Gene Name : PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) [ Homo sapiens ]
Synonyms : H731; MGC33046; MGC33047; PDCD4;Programmed cell death protein 4; Nuclear antigen H731-like; Neoplastic transformation inhibitor protein; Protein 197/15a; programmed cell death 4; nuclear antigen H731
Gene ID : 27250
mRNA Refseq : NM_014456
Protein Refseq : NP_055271
MIM : 608610
UniProt ID : Q53EL6
Chromosome Location : 10q24
Function : RNA binding; protein binding

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
04/03/2021

    Good solubility and stability in solution.

    01/27/2021

      The purity is good, and the results obtained after analysis by SDS-PAGE or Western blot are good.

      01/12/2021

        Short half-life and high clearance.

        Q&As (6)

        Ask a question
        Can PDCD4 be used as a target for sequencing signals? 02/21/2022

        Yes, PDCD4 is involved in the regulation of NF-κB signaling pathway and other biological processes of sequencing signals, and can be a target for sequencing signals.

        How can changes in the expression and function of PDCD4 be assessed? 11/14/2021

        Immunodeficiency method, Western blot, fluorescence microscopy and other techniques can be used to evaluate the changes in the expression and function of PDCD4.

        What is the role of PDCD4 in intestinal disease? 07/22/2021

        It may be involved in processes such as proliferation, apoptosis, and inflammatory response of intestinal epithelial cells, and is associated with intestinal diseases.

        What is the role of PDCD4 in neurological disorders? 12/25/2020

        PDCD4 may be related to neuronal apoptosis, neuroinflammatory response, etc. in neurological diseases.

        What is the relationship between PDCD4 and liver disease? 08/26/2020

        PDCD4 is involved in the regulation of hepatocyte growth, apoptosis and transformation, and may play a role in the occurrence and development of liver diseases.

        How can the information from PDCD4 be used for the development of therapeutic strategies? 08/13/2020

        Through in-depth study of the signaling pathways and regulatory mechanisms of PDCD4, we can provide important clues for the development of therapeutic strategies for related diseases.

        Ask a Question for All PDCD4 Products

        Required fields are marked with *

        My Review for All PDCD4 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2025 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends