Urokinase (trade name Abbokinase), also called urokinase-type plasminogen activator (uPA), is a serine protease (EC 22.214.171.124). Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive zymogen form of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
ATF; ATF uPA; Plasminogen activator; Plasminogen activator urinary; Plasminogen activator urokinase; PLAU; u PA; U plasminogen activator; U-plasminogen activator; UPA; URK; UROK_HUMAN; Urokinase plasminogen activator; Urokinase type plasminogen activator; Urokinase type plasminogen activator precursor; Urokinase-type plasminogen activator chain B;
Plaur involved in several pathways and played different roles in them. We selected most pathways Plaur participated on our site, such as Complement and coagulation cascades, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with Plaur were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Plaur has several biochemical functions, for example, enzyme binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Plaur itself. We selected most functions Plaur had, and list some proteins which have the same functions with Plaur. You can find most of the proteins on our site.
Plaur has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Plaur here. Most of them are supplied by our site. Hope this information will be useful for your research of Plaur.