| Description : |
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
32.1 kDa |
| Protein Length : |
335 |
| AA Sequence : |
MGHPPLLPLLLLLHTCVPASWGLRC MQCKTNGDCRVEECALGQDLCRTTI VRLWEEGEELELVEKSCTHSEKTNR TLSYRTGLKITSLTEVVCGLDLCNQ GNSGRAVTYSRSRYLECISCGSSDM SCERGRHQSLQCRSPEEQCLDVVTH WIQEGEEGRPKDDRHLRGCGYLPGC PGSNGFHNNDTFHFLKCCNTTKCNE GPILELENLPQNGRQCYSCKGNSTH GCSSEETFLIDCRGPMNQCLVATGT HEPKNQSYMVRGCATASMCQHAHLG DAFSMNHIDVSCCTKSGCNHPDLDV QYRSGAAPQPGPAHLSLTITLLMTA RLWGGTLLWT |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
