Active PLAUR protein-coupled magnetic Beads

Species :	Human
Source :	HEK293
Appearance :	Powder mixture
Particle size :	2 μm
Bio-activity :	Immobilized 48.8μg Biotinylated Human uPAR protein to 1mg Beads can bind the Anti-uPAR Antibody with an EC50 0.52 μg/mL.
Coupled amount of protein :	≈1371pmol(48μg) uPAR protein/mg beads
Capacity :	>277pmol (20μg) Anti-uPAR Ab/mg beads
Formulation :	PBS, pH7.4, with 10% Trehalose
Reconstitution :	2 mL sterile deionized water (1 mg beads/mL)
Background :	Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR.
Application :	This product is intended for immunocapture, biopanning and flow cytometry. This product is produced non-sterile.
Storage :	Upon receipt, please store the Beads at -20°C for 1 year in lyophilized state.