| Description : |
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
37 kDa |
| AA Sequence : |
MGHPPLLPLLLLLHTCVPASWGLRC MQCKTNGDCRVEECALGQDLCRTTI VRLWEEGEELELVEKSCTHSEKTNR TLSYRTGLKITSLTEVVCGLDLCNQ GNSGRAVTYSRSRYLECISCGSSDM SCERGRHQSLQCRSPEEQCLDVVTH WIQEGEEGRPKDDRHLRGCGYLPGC PGSNGFHNNDTFHFLKCCNTTKCNE GPILELENLPQNGRQCYSCKGNSTH GCSSEETFLIDCRGPMNQCLVATGT HEPKNQSYMVRGCATASMCQHAHLG DAFSMNHIDVSCCTKSGCNHPDLDV QYRSGAAPQPGPAHLSLTITLLMTA RLWGGTLLWTTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
