Active Recombinant Full Length Human PLAUR Protein, C-Flag-tagged

• Cat.No.: PLAUR-338HFL
• Product Overview: Recombinant Full Length Human PLAUR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Dimerization assay (confocal)
• Molecular Mass: 34.6 kDa
• AA Sequence: MGHPPLLPLLLLLHTCVPASWGLRC MQCKTNGDCRVEECALGQDLCRTTI VRLWEEGEELELVEKSCTHS EKTNRTLSYRTGLKITSLTEVVCGL DLCNQGNSGRAVTYSRSRYLECISC GSSDMSCERGRHQSLQCRSP EEQCLDVVTHWIQEGEEGRPKDDRH LRGCGYLPGCPGSNGFHNNDTFHFL KCCNTTKCNEGPILELENLP QNGRQCYSCKGNSTHGCSSEETFLI DCRGPMNQCLVATGTHEPKNQSYMV RGCATASMCQHAHLGDAFSM
  NHIDVSCCTKSGCNHPDLDVQYRSG AAPQPGPAHLSLTITLLMTARLWGG TLLWTTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades

Gene Information

• Gene Name: PLAUR plasminogen activator, urokinase receptor [ Homo sapiens (human) ]
• Official Symbol: PLAUR
• Synonyms: CD87; UPAR; URKR; U-PAR
• Gene ID: 5329
• mRNA Refseq: NM_002659.4
• Protein Refseq: NP_002650.1
• MIM: 173391
• UniProt ID: Q03405