PLXNA1

  • Official Full Name

    plexin A1

  • Overview

    Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
  • Synonyms

    PLXNA1; plexin A1; NOV; NOVP; PLXN1; PLEXIN-A1; plexin-A1; plexin 1; semaphorin receptor NOV;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLXNA1-509H Recombinant Human PLXNA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLXNA1-508H Recombinant Human PLXNA1 Protein, His-tagged E.coli His Thr43~Ile300
Human PLXNA1-1714H-B Recombinant Human PLXNA1 Protein Pre-coupled Magnetic Beads HEK293
Human PLXNA1-1720H Recombinant Human PLXNA1 Protein (986-1152 aa), His-tagged Yeast His 986-1152 aa
Human PLXNA1-3125H Recombinant Human PLXNA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PLXNA1-1714H Recombinant Human PLXNA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PLXNA1-1329HFL Recombinant Full Length Human PLXNA1 Protein, C-Flag-tagged Mammalian cells Flag
Human PLXNA1-4893H Recombinant Human PLXNA1 protein, His-tagged E.coli His 986-1152aa
Human PLXNA1-4894H Recombinant Human PLXNA1 protein, His-tagged E.coli His 32-296aa
Mouse PLXNA1-12998M Recombinant Mouse PLXNA1 Protein Mammalian Cell His
Mouse PLXNA1-6864M-B Recombinant Mouse PLXNA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PLXNA1-6864M Recombinant Mouse PLXNA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Plxna1-4948M Recombinant Mouse Plxna1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PLXNA1 involved in several pathways and played different roles in them. We selected most pathways PLXNA1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLXNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceSCN9A;SEMA5B;MET;NRP2;EFNA2A;ST8SIA2;ARPC2;AP2M1;DUSP10

PLXNA1 has several biochemical functions, for example, receptor activity, semaphorin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLXNA1 itself. We selected most functions PLXNA1 had, and list some proteins which have the same functions with PLXNA1. You can find most of the proteins on our site.

Function Related Protein
receptor activityF2RL1.2;CD2;GUCY1B3;TNFRSF11A;LILRA2;CMKLR1;GRIK3;GRIA2A;KLRG1
semaphorin receptor activityPLXND1;PLXNB2A;PLXNC1;NRP1B;PLXNA1;NRP1;NRP2A;PLXNB2B;PLXNA1B

PLXNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLXNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLXNA1.

PDIA3

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does PLXNA1 play in synaptic formation? 06/23/2023

PLXNA1 plays a role in the formation of synapses, essential for effective neural communication.

How does PLXNA1 interact with other signaling molecules in neural pathways? 10/29/2022

PLXNA1 interacts with various signaling molecules, coordinating complex neural development processes.

What is the impact of altered PLXNA1 activity on neurodevelopmental disorders? 05/22/2022

Altered PLXNA1 activity is linked to neurodevelopmental disorders due to its role in neuronal guidance and synapse formation.

What is the primary role of PLXNA1 in neural development? 02/08/2022

PLXNA1, a receptor in the plexin family, is crucial for neuronal development and pathway formation.

What potential therapeutic applications arise from targeting PLXNA1 in neurological conditions? 10/12/2019

Targeting PLXNA1 offers potential for treating conditions related to neural development and connectivity.

How does PLXNA1 contribute to axon guidance? 10/02/2018

It guides axon growth and direction, influencing the wiring of the nervous system.

How do genetic variations in PLXNA1 affect neural connectivity? 03/26/2018

Genetic mutations in PLXNA1 can disrupt neural pathways, affecting brain structure and function.

Customer Reviews (3)

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Reviews
05/30/2023

    Critical for decision-making, a research necessity.

    03/26/2022

      Expert service quality, a trusted research ally.

      04/28/2021

        Consistent and trustworthy, boosts our research credibility.

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