Description : |
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
211.1 kDa |
AA Sequence : |
MPLPPRSLQVLLLLLLLLLLLPGMW AEAGLPRAGGGSQPPFRTFSASDWG LTHLVVHEQTGEVYVGAVNRIYKLS GNLTLLRAHVTGPVEDNEKCYPPPS VQSCPHGLGSTDNVNKLLLLDYAAN RLLACGSASQGICQFLRLDDLFKLG EPHHRKEHYLSSVQEAGSMAGVLIA GPPGQGQAKLFVGTPIDGKSEYFPT LSSRRLMANEEDADMFGFVYQDEFV SSQLKIPSDTLSKFPAFDIYYVYSF RSEQFVYYLTLQLDTQLTSPDAAGE HFFTSKIVRLCVDDPKFYSYVEFPI GCEQAGVEYRLVQDAYLSRPGRALA HQLGLAEDEDVLFTVFAQGQKNRVK PPKESALCLFTLRAIKEKIKERIQS CYRGEGKLSLPWLLNKELGCINSPL QIDDDFCGQDFNQPLGGTVTIEGTP LFVDKDDGLTAVAAYDYRGRTVVFA GTRSGRIRKILVDLSNPGGRPALAY ESVVAQEGSPILRDLVLSPNHQYLY AMTEKQVTRVPVESCVQYTSCELCL GSRDPHCGWCVLHSICSRRDACERA DEPQRFAADLLQCVQLTVQPRNVSV TMSQVPLVLQAWNVPDLSAGVNCSF EDFTESESVLEDGRIHCRSPSAREV APITRGQGDQRVVKLYLKSKETGKK FASVDFVFYNCSVHQSCLSCVNGSF PCHWCKYRHVCTHNVADCAFLEGRV NVSEDCPQILPSTQIYVPVGVVKPI TLAARNLPQPQSGQRGYECLFHIPG SPARVTALRFNSSSLQCQNSSYSYE GNDVSDLPVNLSVVWNGNFVIDNPQ NIQAHLYKCPALRESCGLCLKADPR FECGWCVAERRCSLRHHCAADTPAS WMHARHGSSRCTDPKILKLSPETGP RQGGTRLTITGENLGLRFEDVRLGV RVGKVLCSPVESEYISAEQIVCEIG DASSVRAHDALVEVCVRDCSPHYRA LSPKRFTFVTPTFYRVSPSRGPLSG GTWIGIEGSHLNAGSDVAVSVGGRP CSFSWRNSREIRCLTPPGQSPGSAP IIININRAQLTNPEVKYNYTEDPTI LRIDPEWSINSGGTLLTVTGTNLAT VREPRIRAKYGGIERENGCLVYNDT TMVCRAPSVANPVRSPPELGERPDE LGFVMDNVRSLLVLNSTSFLYYPDP VLEPLSPTGLLELKPSSPLILKGRN LLPPAPGNSRLNYTVLIGSTPCTLT VSETQLLCEAPNLTGQHKVTVRAGG FEFSPGTLQVYSDSLLTLPAIVGIG GGGGLLLLVIVAVLIAYKRKSRDAD RTLKRLQLQMDNLESRVALECKEAF AELQTDIHELTNDLDGAGIPFLDYR TYAMRVLFPGIEDHPVLKEMEVQAN VEKSLTLFGQLLTKKHFLLTFIRTL EAQRSFSMRDRGNVASLIMTALQGE MEYATGVLKQLLSDLIEKNLESKNH PKLLLRRTESVAEKMLTNWFTFLLY KFLKECAGEPLFMLYCAIKQQMEKG PIDAITGEARYSLSEDKLIRQQIDY KTLTLNCVNPENENAPEVPVKGLDC DTVTQAKEKLLDAAYKGVPYSQRPK AADMDLEWRQGRMARIILQDEDVTT KIDNDWKRLNTLAHYQVTDGSSVAL VPKQTSAYNISNSSTFTKSLSRYES MLRTASSPDSLRSRTPMITPDLESG TKLWHLVKNHDHLDQREGDRGSKMV SEIYLTRLLATKGTLQKFVDDLFET IFSTAHRGSALPLAIKYMFDFLDEQ ADKHQIHDADVRHTWKSNCLPLRFW VNVIKNPQFVFDIHKNSITDACLSV VAQTFMDSCSTSEHKLGKDSPSNKL LYAKDIPNYKSWVERYYADIAKMPA ISDQDMSAYLAEQSRLHLSQFNSMS ALHEIYSYITKYKDEILAALEKDEQ ARRQRLRSKLEQVVDTMALSSTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |