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POLA1

  • Official Full Name

    polymerase (DNA directed), alpha 1, catalytic subunit

  • Overview

    This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication.
  • Synonyms

    POLA1; polymerase (DNA directed), alpha 1, catalytic subunit; POLA, polymerase (DNA directed), alpha , polymerase (DNA directed), alpha 1; DNA polymerase alpha catalytic subunit; p180; DKFZp686K1672; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; DPOLA_HUMAN; OTTHUMP00000023089; OTTHUMP00000023090; p180 subunit; POLA; Polymerase (DNA-directed), alpha (70kD);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HeLa
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLA-938H Recombinant Human POLA1 protein HeLa N/A
Human POLA1-28359TH Recombinant Human POLA1 Wheat Germ N/A 100 amino acids
Human POLA1-8020H Recombinant Human POLA1 protein, His & T7-tagged E.coli His/T7 Gly1240~Ser1462 (Accession # P09884)
Human POLA1-2944H Recombinant Human POLA1 protein, His-tagged E.coli His 1-217 aa
Human POLA1-4949H Recombinant Human POLA1 Protein (Gly1240-Ser1462), N-His tagged E.coli N-His Gly1240-Ser1462
Mouse Pola1-8021M Recombinant Mouse Pola1 protein, His & T7-tagged E.coli His/T7 Ala1209~Ser1465 (Accession # P33609)
Rat POLA1-4560R Recombinant Rat POLA1 Protein Mammalian Cell His
Rat POLA1-4220R Recombinant Rat POLA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat POLA1-4220R-B Recombinant Rat POLA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

POLA1 involved in several pathways and played different roles in them. We selected most pathways POLA1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismNT5C1B;ALLC;NT5M;TWISTNB;GMPS;ADAL;NME2B.1;PDE4B;XDH
Pyrimidine metabolismPOLR1C;TYMS;NME3;TRR1;NT5C1BA;CMPK1;TK2;NME2A;POLR2G
Metabolic pathwaysPLA2G4F;NAMPT;PCYT1BB;NOS1;DCT;AMY2A5;NDUFV1;ATP5J2;RPN2
DNA replicationRNASEH2C;MCM4;POLE4;RFC1;MCM10;FEN1;MCM7;POLA1;GINS4

POLA1 has several biochemical functions, for example, 3-5 exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLA1 itself. We selected most functions POLA1 had, and list some proteins which have the same functions with POLA1. You can find most of the proteins on our site.

Function Related Protein
3-5 exonuclease activityPOLE;RAD9B;TREX1;REXO2;EXD1;POLA1;WRN;POLG;APLF
4 iron, 4 sulfur cluster bindingTYW1B;DDX11;NDUFS2;MOCS1;CDKAL1;POLD1;IREB2;NFU1;PRIM2
DNA bindingEP400;ZFP639;PHOX2BB;NOTO;ZFP292;WRN;HIST1H2AE;NANOG;ZNF383
contributes_to DNA primase activity
DNA-directed DNA polymerase activityPOLM;POLD1;POLD2;POLI;POLB;POLE3;POLN;CHRAC1;CCDC111
chromatin bindingPOLR3D;TCF7;EZH2;TOX4;ING5;BEND6;CBX5;KDM5A;DNMT1
metal ion bindingPRDM16;DMRTC2;IKBKG;ZNF786;PLCD3A;GALNT11;FBXO30B;MKRN4;IDI2
nucleoside bindingACTN4;POLA1;CDA;PNP;AASS
nucleotide bindingRHOGC;ORC4;REV3L;ARF3A;TDRD9;JAK2B;CKMT2B;EIF3G;NMRK2
protein bindingATOX1;C19orf10;HEMGN;AGO2;CYHR1;TRAM2;PDE4DIP;RNASE1;SLMAP
protein heterodimerization activityPDX1;SDCBP;MID2;H3F3A;ADIPOR1;KCNH5;TP53;CLCN3;HIST1H2AI
protein kinase bindingTP73;NEK9;BCL10;MSH2;PPP1R12B;ELP2;PTEN;CRY1;KCNQ3

POLA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLA1.

lt_sv40; obp_hhv11; E1; CHM; RPA1; SMC1A; KDM4A; PRIM1

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