POU5F1

  • Official Full Name

    POU class 5 homeobox 1

  • Overview

    This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewings sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
  • Synonyms

    POU5F1; POU class 5 homeobox 1; OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; POU domain, class 5, transcription factor 1; octamer-binding protein 3; octamer-binding protein 4; POU domain transcription factor OCT4; octamer-binding transcription factor 3; POU-type homeodomain-containing DNA-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • 11R
  • Arg
  • Flag
  • His
  • His (Fc)
  • Avi
  • B2M
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • TAT
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POU5F1-116H Recombinant Human POU5F1 protein, His-tagged E.coli His
Human POU5F1-3628H Recombinant Human POU Class 5 Homeobox 1 E.coli N/A
Human POU5F1-28780TH Recombinant Human POU5F1 E.coli N/A 212 amino acids
Human POU5F1-113H Recombinant Human POU5F1 Protein, 11R-tagged E.coli 11R
Human POU5F1-117H Recombinant Human POU5F1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human POU5F1-3631H Recombinant Human POU Class 5 Homeobox 1 E.coli N/A
Human POU5F1-8470H Recombinant Human POU5F1, His-tagged E.coli His
Human POU5F1-321H Recombinant Human POU5F1 protein, His-tagged E.coli His
Human POU5F1-639H Recombinant Human POU5F1 Protein, His-tagged E.coli His Ser136~Asn360
Human POU5F1-3000HCL Recombinant Human POU5F1 293 Cell Lysate HEK293 N/A
Human POU5F1-2999HCL Recombinant Human POU5F1 293 Cell Lysate HEK293 N/A
Human POU5F1-3359H Recombinant Human POU5F1 protein, His-B2M-tagged E.coli His-B2M 1-360aa
Human POU5F1-5938H Recombinant Human POU5F1 Protein (Ser136-Ser289), N-His tagged E.coli N-His Ser136-Ser289
Human POU5F1-1740H Recombinant Human POU5F1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human POU5F1-327HFL Active Recombinant Full Length Human POU5F1 Protein, C-Flag-tagged Mammalian cells Flag
Human POU5F1-1740H-B Recombinant Human POU5F1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pou5f1-640M Recombinant Mouse Pou5f1 Protein, His-tagged E.coli His Ser129~Asn352
Mouse Pou5f1-164M Recombinant Mouse Pou5f1, Arg-tagged E.coli Arg
Mouse Pou5f1-200M Recombinant Mouse Pou5f1, TAT-tagged E.coli TAT
Mouse Pou5f1-5024M Recombinant Mouse Pou5f1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque POU5F1-3533R Recombinant Rhesus monkey POU5F1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque POU5F1-3351R Recombinant Rhesus Macaque POU5F1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POU5F1-3351R-B Recombinant Rhesus Macaque POU5F1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

POU5F1 involved in several pathways and played different roles in them. We selected most pathways POU5F1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with POU5F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsHAND1;ESRRB;BMPR1A;FGFR2;NRAS;ZFHX3;INHBA;PCGF6;WNT2

POU5F1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, miRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POU5F1 itself. We selected most functions POU5F1 had, and list some proteins which have the same functions with POU5F1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNR5A2;HIST1H4A;HER4.2;IRX3A;AIFM1;NR2C1;CARF;TOX;IRF1B
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXJ1B;HIF1AL2;FOXK1;SOX30;SP4;ATF5;ZNF576;PLAGL1;ZNF202
miRNA bindingPOU5F1;EIF2C3;MEF2C;TARBP2;RBM4;TRIM71;DICER1;AGO3;AGO2
poly(A) RNA bindingATXN2;THOC4;RBM12B2;RPL22;PRPF6;HNRNPAB;MRPS7;CCBL2;CSDE1
protein bindingGCC1;DAPK3;HTR3C;DSTN;RELA;CST2;TMEM41A;LHFPL5;HDHD2
sequence-specific DNA bindingRX2;ZNF394;DMRTA2;NR1D2B;HOXB8;TBX1;NFYB;MTPN;LHX2B
transcription factor activity, sequence-specific DNA bindingNR2F1;ZFP1;BACH1A;SOX11B;HOXD3A;ZIC1;FLI1;TCF7L1A;ZFY2
transcription factor bindingMED12L;CSNK2B;HIF1A;TRIB2;PSMD10;SMAD2;SNF8;DNMT1;APBB2
transcription regulatory region DNA bindingArid4b;POU5F1;HIVEP2;GABPB1;CREB3L1;XRCC6;CBX4;BCL11AB;CTCFL
transcription regulatory region sequence-specific DNA bindingSUV39H1;NFKB1;NR5A2;NFE2L2B;FOXJ1;ARNTL;MKL1;ARNTL1A;NONO
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingGLIS1;ESX1;BCL6AB;ZC3H8;ARHGAP35;SNAI3;VAX2;NR2F6;E2F7
ubiquitin protein ligase bindingWFS1;HSPA8;PRKAR2A;PCBP2;POU5F1;UBE2W;JKAMP;HSPD1;Fzd4

POU5F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POU5F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POU5F1.

WWP2; Hmgb1; e1a_ade12; E1A; FOXD3; UBE2E1; UBA1; NCL; Hmgb2; SOX2; htrA; SOX17

Research Area

Related articles

Lippok, B; Song, S; et al. Pou5f1 Protein Expression and Posttranslational Modification During Early Zebrafish Development. DEVELOPMENTAL DYNAMICS 243:468-477(2014).
Akhondi, MM; Mohazzab, A; et al. Propagation of human germ stem cells in long-term culture. IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE 11:551-558(2013).
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