prame Protein, preferentially expressed antigen in melanoma


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Official Full Name preferentially expressed antigen in melanoma
Background This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Synonyms PRAME; preferentially expressed antigen in melanoma; MAPE; melanoma antigen preferentially expressed in tumors; cancer/testis antigen 130; CT130; 4930534P07Rik; OIP 4; OIP-4; OIP4; OPA interacting protein 4; Opa interacting protein OIP4; OPA-interacting protein 4; PRAME_HUMAN; Preferentially expressed antigen of melanoma; RP23-250F8.3; Opa-interacting protein OIP4
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Yeast
    • Tag :
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRAME-1492H Recombinant Human PRAME Protein (1-509 aa), His-tagged Yeast His
    Human PRAME-2874H Recombinant Human PRAME Protein, His-tagged E.coli His
    Human PRAME-2895HCL Recombinant Human PRAME 293 Cell Lysate HEK293 N/A
    Human PRAME-2896HCL Recombinant Human PRAME 293 Cell Lysate HEK293 N/A
    Human PRAME-2897HCL Recombinant Human PRAME 293 Cell Lysate HEK293 N/A
    Human PRAME-723H Recombinant Human PRAME Protein, His-tagged E.coli His
    Human PRAME-724H Recombinant Human PRAME Protein, His/GST-tagged E.coli His/GST

    prame involved in several pathways and played different roles in them. We selected most pathways prame participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with prame were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    prame has several biochemical functions, for example, protein binding, retinoic acid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by prame itself. We selected most functions prame had, and list some proteins which have the same functions with prame. You can find most of the proteins on our site.

    Function Related Protein
    protein binding AVPR1A; SOX10; NUP62; H2-AA; CLDN2; FGF1; VPS72; UBE2D3; MSH3; TXN2
    retinoic acid receptor binding PRAMEF2; SNW1; PRAMEF1; NSD1; PRAMEF10; HMGA1-RS1; CNOT1; CTBP2; PRAMEF6; PRAME

    prame has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with prame here. Most of them are supplied by our site. Hope this information will be useful for your research of prame.

    CUL2; TCEB1; TCEB2; b4dyc6_human; PSMD2; HSP90AB1

    Luetkens, T; Kobold, S; et al. Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation. CANCER IMMUNOLOGY IMMUNOTHERAPY 63:1151-1162(2014).
    Hemminger, JA; Toland, AE; et al. Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma. MODERN PATHOLOGY 27:1238-1245(2014).

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