Recombinant Human PRAME Protein, His-tagged

• Cat.No.: PRAME-2874H
• Product Overview: Recombinant Human PRAME protein, fused to His-tagged at N-terminus, was expressed in E. coli.

Specification

• Description: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25 mM Tris, pH 8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 57.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PRAME preferentially expressed antigen in melanoma [ Homo sapiens ]
• Official Symbol: PRAME
• Synonyms: CT130; MAPE; OIP-4; OIP4
• Gene ID: 23532
• mRNA Refseq: NM_006115
• Protein Refseq: NP_006106
• MIM: 606021
• UniProt ID: P78395