prkaa1
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  • Official Full Name
  • protein kinase, AMP-activated, alpha 1 catalytic subunit
  • Background
  • The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; 5-AMP-activated protein kinase catalytic subunit alpha-1; AMPK; alpha; 1; AMPKa1; AMPK alpha 1; AMPK subunit alpha-1; tau-protein kinase PRKAA1; AMP -activate kinase alpha 1 subunit; AMP-ac
Cat.#:PRKAA1-2953HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRKAA1 Protein, MYC/DDK-tagged
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Cat.#:PRKAA1-1944HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1, GST-tagged
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Cat.#:PRKAA1-371HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
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Cat.#:PRKAA1-372HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
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Cat.#:PRKAA1-373HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His/MBP-tagged
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Cat.#:PRKAA1-40HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B1/G2 subunits), GST-His-tagged
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Cat.#:PRKAA1-41HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B1/G3 subunits), GST-His-tagged
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Cat.#:PRKAA1-42HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A1/B2/G1 subunits), GST-His-tagged
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Cat.#:PRKAA1-612HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRKAA1
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Cat.#:PRKAA1-740HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKAA1, GST-His
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Cat.#:PRKAA1-76HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G2), GST-His-tagged
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Cat.#:PRKAA1-775HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA1 protein, His & T7-tagged
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Cat.#:PRKAA1-77HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G3), GST-His-tagged
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Cat.#:Prkaa1-144RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prkaa1(T172D), GST/MYC-tagged
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Cat.#:PRKAA1-4668RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAA1 Protein
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Cat.#:PRKAA1-3399CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAA1
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Cat.#:PRKAA1-6131ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKAA1
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Cat.#:AMPK(A1/B2/G1)-244HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A1/B2/G1), His-tagged, Active
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Cat.#:PRKAA1-1412HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKAA1 cell lysate
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Involved Pathway

PRKAA1 involved in several pathways and played different roles in them. We selected most pathways PRKAA1 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
USP7; G6PC; HRASA; S1PR4; CCNB1; GADD45BB; PIK3CB; MAPK10; RAF1; AGAP2
Regulation of autophagy
PRKAA2; ATG4D; ULK1; ATG14; IFNA14; IFNA5; IFNG; GABARAPL2; Ifna15; IFNA4
mTOR signaling pathway
ULK2; STRADA; PIK3R3A; RPS6KB2; PIK3CG; IGF1; RPS6KA6; PRKAA1; CAB39; PRKCG
PIK-Akt signaling pathway
TSC2; EPO; ITGA4; PDGFD; IGF1; CREB3L2; LAMB1; Ifna11; PIK3CG; PPP2R5A
AMPK signaling pathway
CREB1; PFKM; PIK3CB; PPP2R5A; PPP2R2D; PIK3CD; CPT1B; TSC1; RHEB; IRS2
Circadian rhythm
BTRC; PRKAA2; PRKAA1; CRY2; PRKAG2; NR1D1; RORB; FBXL3; NPAS2; CUL1
Insulin signaling pathway
RPTOR; INPPL1; PRKAG2A; PIK3R3; INS2; SOCS3; PRKAG3B; MAPK9; MAP2K1; RAPGEF1
Adipocytokine signaling pathway
AKT2L; PRKAA2; PRKAB1B; ACSL5; JAK2B; MAPK8; MAPK8B; TNFRSF1A; ACSL3B; RELA
Oxytocin signaling pathway
ITPR3; PPP3R1; CCND1; CAMK4; CAMKK2; NFATC3; ROCK2; OXTR; NFATC1; MYL6
Glucagon signaling pathway
PLCB4; CALM3; PCK1; SMEK1; PLCB1; ACACB; G6PC3; PHKB; SLC2A2; PRKAG1
Insulin resistance
PRKAG1; G6PCA.2; NR1H2; PDPK1B; PIK3R5; SOCS3B; TNFRSF1A; PPP1R3CA; INS2; PIK3CG
Non-alcoholic fatty liver disease (NAFLD)
UQCR10; COX7B; LEP; GSK3B; NDUFA11; XBP1; IRS2; COX7A1; IL1A; PRKAB1
Hypertrophic cardiomyopathy (HCM)
PRKAG1; SGCD; LMNA; ITGA2; PRKAB2; MYBPC3; CACNA2D1; IGF1; TGFB3; TPM3

Protein Function

PRKAA1 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, [acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA1 itself. We selected most functions PRKAA1 had, and list some proteins which have the same functions with PRKAA1. You can find most of the proteins on our site.
Function
Related Protein
Function AMP-activated protein kinase activity
Related Protein ALPK2; PRKAG3; PRKAA2; PRKAB1; PRKAG2; PRKAA1
Function ATP binding
Related Protein INSRA; TTLL1; ADCY1; PAK2B; MAT2A; DYRK2; HNRNPU; MYLK4; DDX59; MAP3K8
Function [acetyl-CoA carboxylase] kinase activity
Related Protein PRKAA2; PRKAA1
Function [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
Related Protein PRKAA1; PRKAA2
Function cAMP-dependent protein kinase activity
Related Protein PRKAA1; PRKACA; PRKX; PRKACB; AKAP13; PRKAG1; PRKACG
Function chromatin binding
Related Protein RBPJ; NR5A5; POLA1; POLG; POU4F2; SMARCE1; TFAP2A; TICRR; TFAM; BARX2
Function histone serine kinase activity
Related Protein AURKA; AURKC; PRKAA2; PRKAA1; AURKB; ATM
Function kinase binding
Related Protein GFAP; PER1; RB1; PARK7; TNFAIP3; CHP; WWC2; JAKMIP1; NTRK1; LDHB
Function metal ion binding
Related Protein PNKD; COL2A1; ENPP5; PNLIP; CHORDC1; ZNF277; ITGA5; SP5A; ZNF410; FLYWCH1
Function protein C-terminus binding
Related Protein PLEKHB1; PIAS4; PPM1A; CDC20; SAE1; CLIC6; EFHC1; DLG3; ERBB2; TFCP2
Function protein binding
Related Protein KRTAP4-2; MAP3K13; WDR4; PLEKHB2; VIM; SPDYE2; PDGFRB; RTN3; DOCK1; OGFR
Function protein kinase activity
Related Protein MAPK12B; PRKCZ; INSRB; TLK1B; MAP3K11; OXSR1B; CDK11A; PRKDC; DYRK1AA; IKBKAP
Function tau-protein kinase activity
Related Protein MARK2; PHKG1; CDK5; PRKAA1; MARK1; MARK4; GSK3B; PHKG2; GSK3A; CSNK1D

Interacting Protein

PRKAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA1.
PRKAB2; PRKAG1