prkab1

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prkab1

Official Full Name protein kinase, AMP-activated, beta 1 non-catalytic subunit
Background The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Synonyms PRKAB1; protein kinase, AMP-activated, beta 1 non-catalytic subunit; AMPK; HAMPKb; 5-AMP-activated protein kinase subunit beta-1; AMPKb; AMPK beta 1; AMPK beta -1 chain; AMPK subunit beta-1; AMP-activated protein kinase beta subunit; 5-AMP-activated protein kinase beta-1 subunit; protein kinase, AMP-activated, noncatalytic, beta-1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • His
    • GST
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AMPK-410HCL Recombinant Human AMPK cell lysate Insect Cell N/A
    Human AMPK-411HCL Recombinant Human AMPK cell lysate Insect Cell N/A
    Human AMPK-412HCL Recombinant Human AMPK cell lysate Insect Cell N/A
    Human AMPK-416HCL Recombinant Human AMPK cell lysate Insect Cell N/A
    Human PRKAB1-1785H Recombinant Human PRKAB1 protein, His & GST-tagged E.coli His/GST
    Human PRKAB1-1945H Recombinant Human PRKAB1, His-tagged E.coli His
    Human PRKAB1-2869HCL Recombinant Human PRKAB1 293 Cell Lysate HEK293 N/A
    Human PRKAB1-3249H Recombinant Human PRKAB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PRKAB1-347H Recombinant Human protein kinase, AMP-activated, beta 1 non-catalytic subunit, His-tagged E.coli His
    Human PRKAB1-370H Recombinant Human PRKAB1 protein, His/MBP-tagged E.coli His/MBP
    Human PRKAB1-4865H Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged Sf9 Insect Cell His
    Human PRKAB1-4866H Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged Sf9 Insect Cell His
    Human PRKAB1-4867H Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged Sf9 Insect Cell His
    Human PRKAB1-4868H Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged Sf9 Insect Cell His
    Human PRKAB1-4869H Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged Sf9 Insect Cell His
    Human PRKAB1-4870H Recombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged Sf9 Insect Cell His
    Mouse Prkab1-5110M Recombinant Mouse Prkab1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PRKAB1-4670R Recombinant Rat PRKAB1 Protein Mammalian Cell His
    Rhesus Macaque PRKAB1-3601R Recombinant Rhesus monkey PRKAB1 Protein, His-tagged Mammalian Cell His
    Chicken PRKAB1-3403C Recombinant Chicken PRKAB1 Mammalian Cell His

    prkab1 involved in several pathways and played different roles in them. We selected most pathways prkab1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with prkab1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway MAP2K2A; MAPK11; TGFB2; HOMER2; PIK3CA; CCNB2; PIK3R1; PLK4; PLK3; PRKAB2
    AMPK signaling pathway G6PC3; CAMKK2; PRKAA2; PPP2R5B; PRKAA1; PPP2R1B; TBC1D1; EEF2K; CAMKK1; CCNA2
    Circadian rhythm PRKAA2; BHLHE40; PRKAB2; RORC; PRKAA1; CRY1; PER1; PER3; PRKAG2; PER2
    Insulin signaling pathway GSK3AA; PPARGC1A; PRKAB1B; EIF4EA; CALM3; FLOT2B; CALM; PRKAR2B; MAP2K2; KRAS
    Adipocytokine signaling pathway CPT1A; STAT3; AKT3A; PTPN11A; TNFRSF1B; CD36; ADIPOQ; TNF; PPARAB; TRAF2
    Oxytocin signaling pathway CACNG4; ROCK1; PPP3CB; MAP2K5; ITPR3; CACNB4; GNAQ; CACNG1; PIK3CB; ROCK2
    Glucagon signaling pathway PGAM1; PRKAG1; PGAM2; PRKAG2; ACACA; SIRT1; PRKACA; LDHB; CREB3L2; CALM4
    Insulin resistance CREB3L3A; IKBKB; SOCS3B; PTENB; SLC2A2; AKT3A; IRS2; PRKCDA; IL6; RPS6KA3B
    Non-alcoholic fatty liver disease (NAFLD) NDUFA4L2; UQCRFS1; NDUFA12; NDUFB1; NFKB1; NDUFC2; COX6B2; NR1H3; NDUFB2; SDHD
    Hypertrophic cardiomyopathy (HCM) PRKAA1; TPM4; ITGB5; ITGA1; ACTG1; TPM2; ITGB6; ITGB4; DAG1; MYL3

    prkab1 has several biochemical functions, for example, AMP-activated protein kinase activity, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by prkab1 itself. We selected most functions prkab1 had, and list some proteins which have the same functions with prkab1. You can find most of the proteins on our site.

    Function Related Protein
    AMP-activated protein kinase activity PRKAB1; PRKAA1; PRKAA2; PRKAG3; ALPK2; PRKAG2
    protein binding PPIE; SNAPIN; POLDIP3; COBRA1; HSFX1; LIMK1; PODXL; SV2B; DLX2; CENPK
    protein kinase activity PRKCHB; IRAK4; CAMK1GB; STK24A; CDK14; AKT3A; RPS6KB1B; CCND1; PTK7A; MAP2K2B
    protein kinase binding CACNB2; TRIM6; PEBP1; TELO2; SNAP91; KCNH1; CCND2; SPDYA; MAG; SYK

    prkab1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with prkab1 here. Most of them are supplied by our site. Hope this information will be useful for your research of prkab1.

    PRKAA1; PRKAG1; PRKAB2; CBR1; Cidea; GRB2

    Brett, KE; Ferraro, ZM; et al. Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta. PLACENTA 36:204-212(2015).
    Banerjee, S; Zagorska, A; et al. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1 beta(MYPT1) phosphatase complex and the SCF beta TrCP E3 ubiquitin ligase. BIOCHEMICAL JOURNAL 461:233-245(2014).

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