|Official Full Name||protein kinase, AMP-activated, beta 1 non-catalytic subunit|
|Background||The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]|
|Synonyms||PRKAB1; protein kinase, AMP-activated, beta 1 non-catalytic subunit; AMPK; HAMPKb; 5-AMP-activated protein kinase subunit beta-1; AMPKb; AMPK beta 1; AMPK beta -1 chain; AMPK subunit beta-1; AMP-activated protein kinase beta subunit; 5-AMP-activated protein kinase beta-1 subunit; protein kinase, AMP-activated, noncatalytic, beta-1;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
prkab1 involved in several pathways and played different roles in them. We selected most pathways prkab1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with prkab1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|FoxO signaling pathway||MAP2K2A; MAPK11; TGFB2; HOMER2; PIK3CA; CCNB2; PIK3R1; PLK4; PLK3; PRKAB2|
|AMPK signaling pathway||G6PC3; CAMKK2; PRKAA2; PPP2R5B; PRKAA1; PPP2R1B; TBC1D1; EEF2K; CAMKK1; CCNA2|
|Circadian rhythm||PRKAA2; BHLHE40; PRKAB2; RORC; PRKAA1; CRY1; PER1; PER3; PRKAG2; PER2|
|Insulin signaling pathway||GSK3AA; PPARGC1A; PRKAB1B; EIF4EA; CALM3; FLOT2B; CALM; PRKAR2B; MAP2K2; KRAS|
|Adipocytokine signaling pathway||CPT1A; STAT3; AKT3A; PTPN11A; TNFRSF1B; CD36; ADIPOQ; TNF; PPARAB; TRAF2|
|Oxytocin signaling pathway||CACNG4; ROCK1; PPP3CB; MAP2K5; ITPR3; CACNB4; GNAQ; CACNG1; PIK3CB; ROCK2|
|Glucagon signaling pathway||PGAM1; PRKAG1; PGAM2; PRKAG2; ACACA; SIRT1; PRKACA; LDHB; CREB3L2; CALM4|
|Insulin resistance||CREB3L3A; IKBKB; SOCS3B; PTENB; SLC2A2; AKT3A; IRS2; PRKCDA; IL6; RPS6KA3B|
|Non-alcoholic fatty liver disease (NAFLD)||NDUFA4L2; UQCRFS1; NDUFA12; NDUFB1; NFKB1; NDUFC2; COX6B2; NR1H3; NDUFB2; SDHD|
|Hypertrophic cardiomyopathy (HCM)||PRKAA1; TPM4; ITGB5; ITGA1; ACTG1; TPM2; ITGB6; ITGB4; DAG1; MYL3|
prkab1 has several biochemical functions, for example, AMP-activated protein kinase activity, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by prkab1 itself. We selected most functions prkab1 had, and list some proteins which have the same functions with prkab1. You can find most of the proteins on our site.
|AMP-activated protein kinase activity||PRKAB1; PRKAA1; PRKAA2; PRKAG3; ALPK2; PRKAG2|
|protein binding||PPIE; SNAPIN; POLDIP3; COBRA1; HSFX1; LIMK1; PODXL; SV2B; DLX2; CENPK|
|protein kinase activity||PRKCHB; IRAK4; CAMK1GB; STK24A; CDK14; AKT3A; RPS6KB1B; CCND1; PTK7A; MAP2K2B|
|protein kinase binding||CACNB2; TRIM6; PEBP1; TELO2; SNAP91; KCNH1; CCND2; SPDYA; MAG; SYK|
prkab1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with prkab1 here. Most of them are supplied by our site. Hope this information will be useful for your research of prkab1.
PRKAA1; PRKAG1; PRKAB2; CBR1; Cidea; GRB2