PRKCD
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Official Full Name
PRKCD protein kinase C, delta
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Synonyms
PRKCD; protein kinase C, delta; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; MAY1; PKCD; nPKC-delta; MGC49908;
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What is PRKCD protein?
PRKCD (protein kinase C delta) gene is a protein coding gene which situated on the short arm of chromosome 3 at locus 3p21. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. PRKCD protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. This protein is consisted of 676 amino acids and is approximately 77.5 kDa.
What is the Function of PRKCD protein?
PRKCD is an important signal regulatory protein, which is involved in the regulation of many cell physiological processes, including apoptosis, cell proliferation and differentiation, inflammatory response and immune response. For example, PRKCD protein can phosphorylate multiple inflammation-related proteins, such as NF-κB, MAPK, etc., and thus participate in the process of inflammation.
PRKCD Related Signaling Pathway
PRKCD can activate several different mitogen-activated protein kinases (MAPKs), such as ERK1/2, p38 and JNK, which are involved in physiological processes such as cell proliferation, differentiation and apoptosis. It can also affect cell growth, differentiation and apoptosis by activating Janus kinase (JAK) and signal transduction and transcriptional activator (STAT) proteins. Or activate nuclear factor κB (NF-κB) through activation of IKK complex and degradation of IκB protein, thereby promoting inflammatory and immune responses.
NF-κB Signaling Pathway from TOCRIS.
PRKCD Related Diseases
PRKCD gene mutations may lead to the development of immune deficiency diseases, such as Wiskott-Aldrich syndrome, and may also lead to the development of autoimmune diseases, such as systemic lupus erythematosus and autoimmune lymphoproliferative syndrome 3 (ALPS3).
Bioapplications of PRKCD
PRKCD protein has a promising application in many disease fields, such as tumor and neurodegenerative diseases, and has the potential to become a new target for drug development and therapeutic strategies.
High Purity
Fig1. SDS-PAGE (PRKCD-653H) (PROTOCOL for western blot)
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Fig2. Activity Data. (PRKCD-3613H)
Case Study 1: HONGYUAN LIANG, 2023
Fig1. Colony formation assay in A549 and NCI-H292 cell lines: This experiment compared the cell colony-forming abilities among three groups: si-NC, si-1 PRKCD, and si-2 PRKCD.
Case Study 2: Xiangyu Li, 2022
Fig2. Measurement of protein expression levels of PRKCD in HepG2 and MHCC97H cells transfected with two PRKCD siRNA sequences, si-NC was utilized as the negative control.
PRKCD involved in several pathways and played different roles in them. We selected most pathways PRKCD participated on our site, such as Chemokine signaling pathway, Vascular smooth muscle contraction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCL15;GNGT2;GM2506;MAP2K1;KRAS;XCL1;CCL16;PPBP;GNAI1 |
| Vascular smooth muscle contraction | KCNMB4;PRKCG;PPP1R14A;AGTR1A;CALM3B;MYL9B;PRKACBB;CYP4A10;GNA11A |
| Tight junction | CLDN15A;GNAI2A;MPP5;PPP2CA;JAM3B;YES1;MYH11A;EPB41L2;SYMPK |
| Fc gamma R-mediated phagocytosis | FCGR2A;RAF1;VASP;PRKCG;ASAP2;PIP5K1A;AKT1;RAC1;cgr2b |
| Neurotrophin signaling pathway | BCL2;MAPK3;IRAK1;NGFR;PRKCD;MAPK10;ZFP110;GSK3B;CAMK2A |
| Inflammatory mediator regulation of TRP channels | CYP2C50;PRKCH;IL1B;CYP4A14;ASIC3;GNAS;PRKCB;TRPV4;CYP2C70 |
| GnRH signaling pathway | CALM1;MAPK12;LHB;MAP3K2;MAP2K4B;MAPK7;GNA11;CGNRH-R;CAMK2B1 |
| Estrogen signaling pathway | SHC4;FOS;NRAS;PRKACA;GNAI2;MAPK3;GNAI3;AKT2;AKT1 |
| Type II diabetes mellitus | HK1;INSR;MAPK9;MAPK8;ADIPOQ;PIK3R1;PKLR;PIK3CA;SLC2A4 |
| Insulin resistance | PRKAG2;PTPN11A;OGT;PRKAB2;PPP1R3CB;PPP2R4;INS2;SLC27A1B;PPP1R3B |
PRKCD has several biochemical functions, for example, ATP binding, calcium-independent protein kinase C activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCD itself. We selected most functions PRKCD had, and list some proteins which have the same functions with PRKCD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CDK3;MAP3K11;PRKCI;MAPK14B;CDK7;RIPK4;RAF1;ACVR1L;LTK |
| calcium-independent protein kinase C activity | PRKCH;PRKCE;PRKCD |
| enzyme activator activity | ALDH1A2;MGST2;APOA5;SFTPB;UBA2;CTAGE5;SFTPBB;RAB3GAP2;MMP24 |
| enzyme binding | NOXA1;GOLPH3;PCCA;RPS19BP1;PDCD2;PARP1;PPP1R3D;MLEC;WWOX |
| insulin receptor substrate binding | PTPN11;GRB2;IGF1RB;INSR;INSRB;INSRA;PIK3R1;IGF1RA;INSRR |
| kinase binding | CEBPA;HPCA;SLC2A1;ABI2;SNAI1;DGKQ;CTNNB1;BCL10;FAS |
| metal ion binding | GALNT7;CHSY1;NEK8;PDE6C;ITGA9;ALOX12E;KIT;ZNF136;ZFP36L2 |
| non-membrane spanning protein tyrosine kinase activity | TYK2;TEC;ZAP70;PTK2AB;MATK;HCK;PTK6;BAZ1B;MELK |
| protein binding | UBE2L6;DYNC1LI1;CIAO1;KRT40;SHKBP1;MECP2;NADK;COA6;COMMD3 |
| protein kinase C activity | PRKCB;PRKCA;PRKCH;PKN3;PRKCBA;PRKCD;PRKCZ;PKN2;PRKCBB |
| protein kinase activity | CDK17;GM4922;CHEK1;CASKA;TNIKA;CDK7;NPR1;STK25B;CDK5R1 |
| protein serine/threonine kinase activity | CDK11A;CSNK1G1;MYLK4;RPS6KA3;MOS;MYO3B;MAP4K1;MAP4K4;CAMK1GB |
PRKCD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCD here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCD.
N/A; FYN; IL32; TOP2A
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Customer Reviews (3)
Write a reviewTheir knowledgeable and responsive team has consistently demonstrated their ability to address any concerns or challenges I have encountered along the way.
Its versatility allows for exploring its various roles and functions, shedding light on its significance in crucial biochemical pathways and cellular processes.
Their support has been invaluable in troubleshooting and providing efficient solutions, enhancing the overall efficiency and productivity of my experiments.
Q&As (5)
Ask a questionLike any targeted therapy, there may be side effects associated with PRKCD inhibitors, and ongoing clinical trials aim to assess the safety profile of these potential treatments.
Yes, PRKCD is implicated in the regulation of inflammation, and its modulation could be explored for the development of anti-inflammatory therapies.
The role of PRKCD in various diseases suggests that it could be a potential target for personalized medicine, tailoring treatments based on an individual's molecular profile.
PRKCD has been found to influence immune response, and its modulation could potentially be harnessed to enhance the body's ability to fight off infections or respond to immunotherapies.
Research suggests that the expression levels of PRKCD may serve as a biomarker for certain cancers, aiding in early diagnosis and prognosis.
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