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PRKCD

  • Official Full Name

    PRKCD protein kinase C, delta

  • Synonyms

    PRKCD; protein kinase C, delta; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; MAY1; PKCD; nPKC-delta; MGC49908;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKCD-579H Active Recombinant Human PRKCD, GST-tagged Sf9 Insect Cell GST
Human PRKCD-198H Active Recombinant Human PRKCD(2-end) Protein, N-His-tagged Sf21 His 2-end
Human PRKCD-401H Recombinant Human Protein Kinase C, Delta, GST-tagged, Active Sf9 Insect Cell GST
Human PRKCD-356H Recombinant Human PRKCD protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRKCD-653H Recombinant Human PRKCD Protein, His-tagged E.coli His Asn330~His672
Human PRKCD-1954H Recombinant Human PRKCD, His-tagged E.coli His 326-676aa
Human PRKCD-61H Recombinant Human Protein Kinase C, Delta, His-tagged Sf9 Insect Cell His
Human PRKCD-357H Recombinant Human PRKCD protein, His-tagged HEK293 His
Human PRKCD-4106H Recombinant Human PRKCD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRKCD-4392HFL Recombinant Full Length Human PRKCD protein, Flag-tagged Mamanlian cells Flag
Human PRKCD-4495H Recombinant Human PRKCD protein, His-tagged E.coli His 1-676aa
Human PRKCD-0198H Recombinant Human PRKCD Protein (A2-D676), Tag Free Insect Cell No tag A2-D676
Human PRKCD-0199H Recombinant Human PRKCD Protein (A2-D676), GST tagged Insect Cell GST A2-D676
Human PRKCD-3613HF Active Recombinant Full Length Human PRKCD Protein, GST-tagged Insect (sf21) GST 1-676
Mouse Prkcd-1357M Recombinant Mouse Prkcd, His & GST tagged Insect Cell His/GST
Mouse Prkcd-654M Recombinant Mouse Prkcd Protein, His-tagged E.coli His Asn328~Ile674
Mouse PRKCD-546MCL Recombinant Mouse PRKCD cell lysate Insect Cell N/A
Mouse Prkcd-5119M Recombinant Mouse Prkcd Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Prkcd-655R Recombinant Rat Prkcd Protein, His-tagged E.coli His Phe347~Phe601
Rat PRKCD-4678R Recombinant Rat PRKCD Protein Mammalian Cell His
Rat PRKCD-4337R Recombinant Rat PRKCD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRKCD-4337R-B Recombinant Rat PRKCD Protein Pre-coupled Magnetic Beads HEK293
Chicken PRKCD-1285C Recombinant Chicken PRKCD Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKCD Related Research Area

What is PRKCD protein?

PRKCD (protein kinase C delta) gene is a protein coding gene which situated on the short arm of chromosome 3 at locus 3p21. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. PRKCD protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. This protein is consisted of 676 amino acids and is approximately 77.5 kDa.

What is the Function of PRKCD protein?

PRKCD is an important signal regulatory protein, which is involved in the regulation of many cell physiological processes, including apoptosis, cell proliferation and differentiation, inflammatory response and immune response. For example, PRKCD protein can phosphorylate multiple inflammation-related proteins, such as NF-κB, MAPK, etc., and thus participate in the process of inflammation.

PRKCD Related Signaling Pathway

PRKCD can activate several different mitogen-activated protein kinases (MAPKs), such as ERK1/2, p38 and JNK, which are involved in physiological processes such as cell proliferation, differentiation and apoptosis. It can also affect cell growth, differentiation and apoptosis by activating Janus kinase (JAK) and signal transduction and transcriptional activator (STAT) proteins. Or activate nuclear factor κB (NF-κB) through activation of IKK complex and degradation of IκB protein, thereby promoting inflammatory and immune responses.

PRKCD-7.jpg

NF-κB Signaling Pathway from TOCRIS.

PRKCD Related Diseases

PRKCD gene mutations may lead to the development of immune deficiency diseases, such as Wiskott-Aldrich syndrome, and may also lead to the development of autoimmune diseases, such as systemic lupus erythematosus and autoimmune lymphoproliferative syndrome 3 (ALPS3).

Bioapplications of PRKCD

PRKCD protein has a promising application in many disease fields, such as tumor and neurodegenerative diseases, and has the potential to become a new target for drug development and therapeutic strategies.

High Purity

High Bioactivity

PRKCD-2.jpg

Fig2. Activity Data. (PRKCD-3613H)

Case Study 1: HONGYUAN LIANG, 2023

PRKCD-3.jpg

Fig1. Colony formation assay in A549 and NCI-H292 cell lines: This experiment compared the cell colony-forming abilities among three groups: si-NC, si-1 PRKCD, and si-2 PRKCD.

Case Study 2: Xiangyu Li, 2022

PRKCD-4.jpg

Fig2. Measurement of protein expression levels of PRKCD in HepG2 and MHCC97H cells transfected with two PRKCD siRNA sequences, si-NC was utilized as the negative control.

PRKCD-5.jpg

MAPK Signaling: Oxidative Stress Pathway from R&D

PRKCD-6.jpg

Jak/STAT Signaling Pathway from R&D

PRKCD involved in several pathways and played different roles in them. We selected most pathways PRKCD participated on our site, such as Chemokine signaling pathway, Vascular smooth muscle contraction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayPIK3CA;PREX1;CX3CR1;Cxcl15;NFKBIA;GM2506;NRAS;PAK1;PRKACA
Vascular smooth muscle contractionPRKACBA;PRKACA;CYP4A14;MYL9B;CALM1B;GNA11B;CALM2A;CALM2;GNA11
Tight junctionPRKCB;TJAP1;PRKCBA;CDC42L;ACTN1;CASKA;CLDN15LA;PPP2R2D;RHOAD
Fc gamma R-mediated phagocytosisPRKCG;PPAP2B;PIP5K1A;WAS;cgr2b;ARPC1A;MARCKS;LIMK2;INPPL1
Neurotrophin signaling pathwayNFKBIE;MAGED1;CALM2;MAPK10;NTRK3;MAP2K5;CAMK4;MAPK8;CALM3
Inflammatory mediator regulation of TRP channelsCALML5;PRKCG;Adcy4;CAMK2G;PIK3R3;HTR2B;SRC;PRKCA;ASIC2
GnRH signaling pathwayFSHB;GNRHR2;GNRHR;PTK2BB;GNRH1;RAF1B;MAP2K2;MAPK14A;PRKCBA
Estrogen signaling pathwayGNAQ;CALML3;PIK3CA;MAPK3;HSPA1L;SHC3;GNAI2;Adcy4;ATF4
Type II diabetes mellitusPKM;SOCS2;SOCS3;IRS1;PIK3R2;PKM2;MAPK1;INS1;PIK3R5
Insulin resistanceG6PCA.1;SLC2A1A;IL6;GFPT2;PRKCBB;PPP1R3A;PTPN11B;FOXO1;GSK3AA

PRKCD has several biochemical functions, for example, ATP binding, calcium-independent protein kinase C activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCD itself. We selected most functions PRKCD had, and list some proteins which have the same functions with PRKCD. You can find most of the proteins on our site.

Function Related Protein
ATP bindingERCC2;CDK15;P2RY1;ATAD5;LTK;TUT1;UBE2E1;RAD51D;PIM1
calcium-independent protein kinase C activityPRKCD;PRKCH;PRKCE
enzyme activator activityARL1;MMP17;CXCL1;GMFG;RAB3GAP2;PSAP;RICTOR;MGST2;TIMP2
enzyme bindingBIRC5;TSPAN14;MARCH6;JUND;TMBIM6;PIAS1;LAMP2;EGFR;RAD9A
insulin receptor substrate bindingPRKCD;GRB2;INSRB;IGF1RB;PIK3CB;INSRR;PTPN11;INSRA;PIK3CA
kinase bindingWWC2;PARK2;PPP1R9B;SIT1;LDHA;CHP;MIDN;PFKL;MOBKL1A
metal ion bindingPMM1;ZKSCAN6;DGKAA;GCM2;METAP1;GZF1;ZNF750;DDHD1B;MPO
non-membrane spanning protein tyrosine kinase activityLCK;TEC;ZNF143B;SRMS;LYN;CLK1;BLK;FES;FGR
protein bindingCLEC18A;RBPMS;UCKL1;ZNF703;DNPEP;CLDN1;CASC3;ADARB1;RTN4R
protein kinase C activityPRKCG;PRKCHB;PRKCE;PRKCD;PKN2;PRKCA;PRKCI;PRKD1;PRKCQ
protein kinase activityRAF1;CSNK2A2A;TNK2B;RNASEL;MAP3K12;MOK;MKNK2B;NEK2;ROCK2A
protein serine/threonine kinase activityGRK7B;RPS6KC1;KALRN;MAP3K12;NIM1;PAK2A;MAPK6;DCLK1;TESK2

PRKCD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCD here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCD.

N/A; FYN; IL32; TOP2A

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any side effects associated with targeting PRKCD in therapy? 10/19/2021

Like any targeted therapy, there may be side effects associated with PRKCD inhibitors, and ongoing clinical trials aim to assess the safety profile of these potential treatments.

Is PRKCD involved in the regulation of inflammation? 11/22/2019

Yes, PRKCD is implicated in the regulation of inflammation, and its modulation could be explored for the development of anti-inflammatory therapies.

Can PRKCD be a target for personalized medicine? 09/25/2019

The role of PRKCD in various diseases suggests that it could be a potential target for personalized medicine, tailoring treatments based on an individual's molecular profile.

How does PRKCD impact immune response? 11/22/2017

PRKCD has been found to influence immune response, and its modulation could potentially be harnessed to enhance the body's ability to fight off infections or respond to immunotherapies.

Can PRKCD be a potential biomarker for cancer diagnosis? 07/05/2016

Research suggests that the expression levels of PRKCD may serve as a biomarker for certain cancers, aiding in early diagnosis and prognosis.

Customer Reviews (3)

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Reviews
09/12/2021

    Their knowledgeable and responsive team has consistently demonstrated their ability to address any concerns or challenges I have encountered along the way.

    04/11/2020

      Its versatility allows for exploring its various roles and functions, shedding light on its significance in crucial biochemical pathways and cellular processes.

      06/17/2018

        Their support has been invaluable in troubleshooting and providing efficient solutions, enhancing the overall efficiency and productivity of my experiments.

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