Pvrl2

  • Official Full Name

    poliovirus receptor-related 2 (herpesvirus entry mediator B)

  • Overview

    This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B); HVEB; PRR2; CD112; PVRR2; poliovirus receptor-related protein 2; nectin-2; poliovirus receptor-like 2; herpesvirus entry protein B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Avi|Fc
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • mFc
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PVRL2-520H Active Recombinant Human PVRL2 Protein, His-tagged Mammalian cells His Gln32-Leu360
Human PVRL2-610H Recombinant Human PVRL2 protein(Met1-Leu360) HEK293 N/A Met1-Leu360
Human PVRL2-40H Recombinant Human PVRL2 protein, T7/His-tagged E.coli T7/His
Human PVRL2-2080H Recombinant Human PVRL2, GST-tagged E.coli GST 1-269AA
Human PVRL2-608H Recombinant Human PVRL2 protein, Fc-tagged HEK293 human/IgG1/Fc Gln32-Leu360
Human PVRL2-609H Active Recombinant Human PVRL2 protein, His-tagged HEK293 His Gln 32 - Leu 360
Human PVRL2-3010HCL Recombinant Human PVRL2 cell lysate Human Cell N/A
Human PVRL2-3952H-B Recombinant Human PVRL2 Protein Pre-coupled Magnetic Beads HEK293
Human PVRL2-2680H Recombinant Human PVRL2 Protein (Gln32-Pro350), His tagged E.coli His Gln32-Pro350
Human CAB11593RH Rabbit Monoclonal Antibody to Human Poliovirus Receptor-related 2 Rabbit N/A
Human PVRL2-377H Active Recombinant Human PVRL2 protein, mFc-tagged HEK293 mFc Gln 32 - Leu 360
Human PVRL2-0571H Active Recombinant Human PVRL2 protein, mFc-Avi-tagged, Biotinylated HEK293 mFc-Avi Gln32-Leu360
Human PVRL2-611H Active Recombinant Human PVRL2 Protein, Fc-Avi-tagged, Biotinylated HEK293 Avi/Fc
Human PVRL2-0572H Active Recombinant Human PVRL2 protein, Fc-tagged HEK293 Fc Gln32-Leu360
Human PVRL2-612H Active Recombinant Human PVRL2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln 32 - Leu 360
Human PVRL2-4653H Recombinant Human PVRL2 protein, His-tagged E.coli His 32-360aa
Human PVRL2-3952H Recombinant Human PVRL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pvrl2-2269M Active Recombinant Mouse Pvrl2 protein(Met1-Gly351), His-tagged HEK293 C-His Met1-Gly351
Mouse PVRL2-2647MCL Recombinant Mouse PVRL2 cell lysate Human Cell N/A
Mouse CAB11594RM Rabbit Monoclonal Antibody to Mouse Poliovirus Receptor-related 2 Rabbit N/A
Mouse Pvrl2-2270M Recombinant Mouse Pvrl2(Gln32-Gly351) Protein, C-Fc-tagged HEK293 Fc
Rat Pvrl2-7488R Recombinant Rat Pvrl2, His tagged Human Cell His
Rat PVRL2-1403RCL Recombinant Rat PVRL2 cell lysate Human Cell N/A
Cynomolgus Monkey PVRL2-611C Recombinant Cynomolgus PVRL2, His-tagged Human Cell His
Rhesus Macaque PVRL2-3715R Recombinant Rhesus monkey PVRL2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PVRL2-3532R-B Recombinant Rhesus Macaque PVRL2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PVRL2-3532R Recombinant Rhesus Macaque PVRL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Pvrl2 involved in several pathways and played different roles in them. We selected most pathways Pvrl2 participated on our site, such as Cell adhesion molecules (CAMs), Adherens junction, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pvrl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CLDN18;Ntng2;CLDN6;ITGB1B.2;F11R.1;CNTNAP2A;NLGN2;MHC1UXA2;OCLNA
Adherens junctionMAP3K7;BAIAP2;PTPRJA;Fert2;YES1;EGFR;CDC42L2;TGFBR2;ACTN3A
Herpes simplex infectionMAPK8A;OAS2;Ccl12;UBE2R2;PER2;BLB2;SRSF1A;SRSF5B;IFNPHI1

Pvrl2 has several biochemical functions, for example, cell adhesion molecule binding, coreceptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pvrl2 itself. We selected most functions Pvrl2 had, and list some proteins which have the same functions with Pvrl2. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingSDCBP;CADM1;TIGIT;ITGB7;NLGN4X;ITGA4;LILRB2;NLGN1;NLGN3
coreceptor activityRGMD;CCR8;ACKR3B;RAMP2;PVRL2;CD80;PVRL1;RGMA;CCR5
identical protein bindingAPOH;RYR2;ST13;COL1A1;APPL1;SEPHS1;HJURP;CD28;TRIM39
protein bindingOLIG1;PLOD3;MSH5;PPHLN1;Casp3;SNTB1;C6orf211;GCC1;NFE2L1
protein homodimerization activityMTMR2;BCL2A1;TIGIT;PDGFC;BNIP3;ENG;TBX1;RAB11FIP4;HNF1A
receptor bindingTNFSF8;INSL3;NRG2A;TAC3;SNX17;GUSB;MBL2;SEMA4D;BMP2
virus receptor activityCR1;HSPA1B;SERPINB3;HAVCR1;CD46;CXADR;SCARB2;ITGB5;CD80

Pvrl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pvrl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Pvrl2.

MDFI; PVRL3; KRTAP5-9; KRTAP10-5

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