RYK
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Official Full Name
receptor-like tyrosine kinase
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Overview
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms. -
Synonyms
RYK; receptor-like tyrosine kinase; JTK5A, JTK5A protein tyrosine kinase , RYK receptor like tyrosine kinase; tyrosine-protein kinase RYK; D3S3195; JTK5; RYK1; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; RYK receptor-like tyrosine kinase;
- Recombinant Proteins
- Homo sapiens (Human)
- Human
- Mouse
- Zebrafish
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Fc
- GST
- His
- Flag
- T7
- Myc
- DDK
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | RYK-633H | Active Recombinant Human RYK, Fc Chimera | CHO | Fc |
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| Human | RYK-262H | Recombinant Human RYK, GST-tagged | Sf9 Insect Cell | GST | 255-end |
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| Human | RYK-31340TH | Recombinant Human RYK | Wheat Germ | Non | 110 amino acids |
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| Human | RYK-694H | Recombinant Human RYK Protein, DDK/His-tagged | HEK293 | His&Flag | Pro26-Arg224 |
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| Human | RYK-1937H | Recombinant Human RYK protein, His & T7-tagged | E.coli | His&T7 | Lys308~Cys570 |
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| Human | RYK-2012H | Recombinant Human RYK Protein, MYC/DDK-tagged | HEK293 | Myc&DDK |
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| Human | RYK-3895H | Recombinant Human RYK protein, His-tagged | E.coli | His | 261-610 aa | |
| Human | RYK-634H | Recombinant Human RYK protein, hFc-tagged | HEK293 | Fc | Met1-Arg227 |
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| Human | RYK-6209H | Recombinant Human RYK Protein (Leu308-Pro568), N-His tagged | E.coli | His | Leu308-Pro568 |
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| Mouse | Ryk-1938M | Recombinant Mouse Ryk protein, His & T7-tagged | E.coli | His&T7 | Thr287~Ile533 |
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| Mouse | Ryk-5663M | Recombinant Mouse Ryk Protein, Myc/DDK-tagged | HEK293T | Myc&DDK |
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| Homo sapiens (Human) | RFL18925HF | Recombinant Full Length Human Tyrosine-Protein Kinase Ryk(Ryk) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (26-607) |
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| Zebrafish | RYK-5445Z | Recombinant Zebrafish RYK | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
RYK involved in several pathways and played different roles in them. We selected most pathways RYK participated on our site, such as Beta-catenin independent WNT signaling, PCP/CE pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Beta-catenin independent WNT signaling | DVL3;PRICKLE1;ROR1;ROR2;CTNNB2;AP2M1;AGO1;RYK;CLTA |
| PCP/CE pathway | RYK;PRICKLE1B;PRICKLE1;ROR1;ROR2 |
| Signal Transduction | OPN4B;TAX1BP1;GRB10A;DLC1;OMG;CBY1;CDH5;LEO1;LPAR2B |
| Signaling by Wnt | PRICKLE1;SOX4B;SOX13;SOX9B;GPR177;ROR1;PYGO1;USP34;SOX9A |
| TCF dependent signaling in response to WNT | SOX4B;BCL9L;SOX6;SOX32;DACT1;SOX9B;WNT8-2;ZNRF3;BCL9 |
| Wnt signaling network | IGFBP4;RSPO1;ATP6AP2;RYK;WIF1;CTHRC1 |
RYK has several biochemical functions, for example, ATP binding, protein binding, NOT protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RYK itself. We selected most functions RYK had, and list some proteins which have the same functions with RYK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX19B;ABCB6;PRKD3;UBE2D1A;GALK2;PAPSS2B;CAD;SMC3;ABCG2B |
| protein binding | ERGIC2;KRTAP10-8;SALL4;LIMK1;PSMB4;STK10;PIKFYVE;RMND1;CHMP4A |
| NOT protein tyrosine kinase activity | RYK;KLHL8;TWF1;ERBB3 |
| transmembrane receptor protein tyrosine kinase activity | INSRA;EK1;ROR2;EPHB2B;EGFRA;EPHB4B;ERBB3A;ERBB4;RYK |
| transmembrane signaling receptor activity | ADCYAP1R1A;IL27RA;DNER;OR12D2;PTH1RB;CALCRLA;CLDN4;IGSF6;CD300C |
RYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYK here. Most of them are supplied by our site. Hope this information will be useful for your research of RYK.
CFTR
Research Area
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