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RYR1

  • Official Full Name

    ryanodine receptor 1 (skeletal)

  • Overview

    Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.
  • Synonyms

    RYR1; ryanodine receptor 1 (skeletal); ryanodine receptor 1; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor; RYR-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RYR1-357H Recombinant Human RYR1 Mammalian Cell His
Human RYR1-789H Recombinant Human RYR1 Protein (1-534 aa), His-tagged E.coli His 1-534 aa
Human RYR1-790H Recombinant Human RYR1 protein (Skeletal), His-tagged E.coli His His97-Cys392
Human RYR1-2037H Recombinant Human RYR1 Protein, His&GST-tagged E.coli N-His&GST His97-Cys392
Human RYR1-4018H Recombinant Human RYR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RYR1-301225H Recombinant Human RYR1 protein, GST-tagged E.coli GST Gly4942-Ser5038
Human RYR1-4018H-B Recombinant Human RYR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ryr1-2669M Recombinant Mouse Ryr1 Protein, His&GST-tagged E.coli N-His&GST His99-Cys394
Rat Ryr1-2038R Recombinant Rat Ryr1 Protein, His-tagged E.coli N-His His99-Cys394
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RYR1 Related Articles

RYR1 involved in several pathways and played different roles in them. We selected most pathways RYR1 participated on our site, such as Calcium signaling pathway, Circadian entrainment, Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RYR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPTAFR;PHKG2;TACR2;DRD1B;PPP3CCA;AKR1C1;ERBB4A;SLC25A5;PLCD4
Circadian entrainmentGNG10;PRKACB;Adcy4;GRIA4;ITPR3;GRIN2D;PRKG1;MAPK3;KCNJ9
Long-term depressionKRAS;GRID2;IGF1;GUCY1A3;GNA13;ITPR3;PLCB4;RYR1;PLCB2
Oxytocin signaling pathwayPRKACG;NFATC1;MYLK;CACNA2D3;MYL6B;SRC;CAMK2D;PRKACA;CALM2

RYR1 has several biochemical functions, for example, calcium channel activity, calcium-release channel activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RYR1 itself. We selected most functions RYR1 had, and list some proteins which have the same functions with RYR1. You can find most of the proteins on our site.

Function Related Protein
calcium channel activityTRPV4;GRIN2A;CATSPER2;GRIN3A;CACNA1SB;TRPC1;TRPM2;PKD2L2;RYR1
calcium-release channel activityRASA3;RYR1;RYR2;RYR3;JPH2;TRPV1;JPH3
calmodulin bindingATP2B4;CDK5RAP2;ITPKA;RYR2;KCNN4;PLCB1;PHKG1B;CAMK4;MAPKAPK2
protease bindingDVL3;NDUFS7;ANXA2;SERPINC1;TIMP4;BDKRB2;SERPINB6;FLOT1;ALPI
protein bindingUBE2V2;PPHLN1;TRAM1;EYA4;NDUFAF4;DHX36;RPL10;ITGA5;CEP104
ryanodine-sensitive calcium-release channel activityRYR3;RYR1B;RYR1;RYR2
voltage-gated calcium channel activityGRM7;CACNG2A;CACNG2B;CACNA1DA;TPCN2;IL1RAPL1;TPC3;CACNB2A;CACNG8

RYR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RYR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RYR1.

MYOM2; PPP1CA; PPP2CA; NCK1; PLCG1; GRB2; TULP3; PDLIM3; TTN; TF

Vukcevic, M; Zorzato, F; et al. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. JOURNAL OF CELL SCIENCE 126:3485-3492(2013).
Thakur, P; Dadsetan, S; et al. Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 287:37233-37244(2012).
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