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Official Full Name ryanodine receptor 1 (skeletal)
Background Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.
Synonyms RYR1; ryanodine receptor 1 (skeletal); ryanodine receptor 1; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor; RYR-1
    • Species :
    • Human
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RYR1-790H Recombinant Human RYR1 protein (Skeletal), His-tagged E.coli His
    Human RYR1-789H Recombinant Human RYR1 Protein (1-534 aa), His-tagged E.coli His
    Human RYR1-357H Recombinant Human RYR1 Mammalian Cell His

    ryr1 involved in several pathways and played different roles in them. We selected most pathways ryr1 participated on our site, such as Calcium signaling pathway, Circadian entrainment, Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ryr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway TNNC2; ORAI3; PLCZ1; TACR1A; PLCD1B; ERBB3B; P2RX1; RYR3; GRM5; SLC8A2B
    Circadian entrainment GNG13; ITPR1; GRIA3; GRIA1; RYR1; PRKCB; PLCB2; GRIN2C; GNG7; GNG3
    Long-term depression GNAQ; MAP2K2; PLCB4; MAPK1; CRH; PLA2G4D; PRKCA; KRAS; GNAO1; MAPK3
    Oxytocin signaling pathway CAMK4; PLA2G4D; PPP3CC; NRAS; PIK3CB; CACNG1; RGS2; KCNJ14; PRKACG; MYL6

    ryr1 has several biochemical functions, for example, calcium channel activity, calcium-release channel activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ryr1 itself. We selected most functions ryr1 had, and list some proteins which have the same functions with ryr1. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity TRPC1; CACNG2A; TMEM37; GRIN3A; CACNA1SB; SLC24A4; TRPC5; TRPV1; CACNG8A; CACNA1C
    calcium-release channel activity RASA3; RYR1; JPH2; TRPV1; JPH3; RYR3; RYR2
    calmodulin binding DAPK1; KCNQ3; MKNK1; PHKG1; SPHK1; MYO7A; CAMKK1; MKNK2A; UBR4; NOS2
    protease binding SERPINE1; LDLR; SELL; PINK1; ANXA2; BRCA2; FURIN; CRADD; CNTNAP2; A2M
    protein binding NEDD8; GPRIN2; LSM6; PDCD4; GNAI3; NOTCH2; LGALS9C; VAPA; PDE4DIP; FSHR
    ryanodine-sensitive calcium-release channel activity RYR3; RYR1B; RYR2; RYR1
    voltage-gated calcium channel activity CACNA1C; CACNA1SB; CACNG2; CACNA1DA; CACNA1D; CACNG7; CACNA2D2; CACNB4B; CALHM1; CACNG7A

    ryr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ryr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ryr1.


    Vukcevic, M; Zorzato, F; et al. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. JOURNAL OF CELL SCIENCE 126:3485-3492(2013).
    Thakur, P; Dadsetan, S; et al. Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes. JOURNAL OF BIOLOGICAL CHEMISTRY 287:37233-37244(2012).

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