S1PR1

  • Official Full Name

    S1PR1 sphingosine-1-phosphate receptor 1

  • Synonyms

    S1PR1; sphingosine-1-phosphate receptor 1; EDG1, endothelial differentiation, sphingolipid G protein coupled receptor, 1; sphingosine 1-phosphate receptor 1; CD363; D1S3362; edg 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; EDG1; S1P1; ECGF1; EDG-1; CHEDG1; FLJ58121;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human S1PR1-569H Recombinant Human S1PR1 Mammalian Cell His
Human S1PR1-28462TH Recombinant Human S1PR1 protein Wheat Germ N/A
Human S1PR1-4038H Recombinant Human S1PR1 Protein, GST-tagged Wheat Germ GST
Human S1PR1-530HCL Recombinant Human S1PR1 cell lysate N/A
Human S1PR1-4725HF Recombinant Full Length Human S1PR1 Protein, GST-tagged In Vitro Cell Free System GST 382 amino acids
Human S1PR1-1118HFL Recombinant Human S1PR1 protein, His&Flag-tagged HEK293 His&Flag 1-382 aa
Human S1PR1-4023H Recombinant Human S1PR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human S1PR1-4023H-B Recombinant Human S1PR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse S1PR1-14628M Recombinant Mouse S1PR1 Protein Mammalian Cell His
Mouse S1PR1-7871M-B Recombinant Mouse S1PR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse S1pr1-2041M Recombinant Mouse S1pr1 Protein, His-tagged E.coli N-His Tyr311-Ser382
Mouse S1PR1-7871M Recombinant Mouse S1PR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat S1PR1-5219R Recombinant Rat S1PR1 Protein Mammalian Cell His
Rat S1PR1-4878R Recombinant Rat S1PR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat S1PR1-4878R-B Recombinant Rat S1PR1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL955BF Recombinant Full Length Bovine Sphingosine 1-Phosphate Receptor 1(S1Pr1) Protein, His-Tagged E.coli expression system His Full Length (1-382)
Danio rerio (Zebrafish) (Brachydanio rerio) RFL15845DF Recombinant Full Length Danio Rerio Sphingosine 1-Phosphate Receptor 1(S1Pr1) Protein, His-Tagged E.coli expression system His Full Length (1-362)
Homo sapiens (Human) RFL1995HF Recombinant Full Length Human Sphingosine 1-Phosphate Receptor 1(S1Pr1) Protein, His-Tagged E.coli expression system His Full Length (1-382)
Mus musculus (Mouse) RFL7405MF Recombinant Full Length Mouse Sphingosine 1-Phosphate Receptor 1(S1Pr1) Protein, His-Tagged E.coli expression system His Full Length (1-382)
Rattus norvegicus (Rat) RFL31955RF Recombinant Full Length Rat Sphingosine 1-Phosphate Receptor 1(S1Pr1) Protein, His-Tagged E.coli expression system His Full Length (1-383)
Zebrafish S1PR1-9218Z Recombinant Zebrafish S1PR1 Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is S1PR1 protein?

S1PR1 (sphingosine-1-phosphate receptor 1) is a protein coding gene which situated on the short arm of chromosome 1 at locus 1p21. The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. The S1PR1 protein is consisted of 382 amino acids and its molecular mass is approximately 42.8 kDa.

What is the function of S1PR1 protein?

S1PR1 protein is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, normal cardiac morphogenesis and normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. It plays an important role in the regulation of sprouting angiogenesis, vascular maturation, the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. It could inhibit sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Also it plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

S1PR1 related Signaling pathways

S1PR1 is one of the five receptors for S1P. When S1P binds to S1PR1, it triggers downstream signaling events that regulate various cellular processes, including an increase in intracellular calcium levels, activation of protein kinase pathways (such as PI3K/Akt and ERK1/2), and regulation of gene expression. Meanwhile, S1P and S1PR1 signaling still plays a role in maintaining the integrity of the blood-brain barrier and T-cell migration from lymphoid organs to peripheral tissues. S1PR1 signaling is also implicated in cardiac function and protection against myocardial ischemia/reperfusion injury.

S1PR1-6.jpg

Fig6. Sphingolipid signaling regulates tight and adherens junctions through S1PRs. All S1PRs can signal via Gi, Gi activation leads to stimulation of phosphoinositide 3-kinases (PI3K) and Tiam1, which stimulate Rac1.

S1PR1 Related Diseases

Dysregulation of S1PR1 signaling has been implicated in various diseases. Some of the diseases associated with S1PR1 dysregulation include: Multiple Sclerosis (MS), Asthma, Cardiovascular diseases such as atherosclerosis, hypertension, and myocardial infarction. S1PR1 is involved in tumor growth, angiogenesis, and metastasis in various types of cancer. Altered expression or activity of S1PR1 has been linked to tumor progression and poor prognosis in several malignancies, including breast cancer, lung cancer, and colorectal cancer. Other diseases like inflammatory bowel disease (IBD) and diabetes are associated with the dysregulation of S1PR1.

Bioapplications of S1PR1

Given S1PR1 plays an important role in a variety of diseases including immunomodulation, cancer, neurological disorders and so on, drug development targeting S1PR1 has become an important therapeutic strategy. For example, Targeting S1PR1 signaling could have implications in promoting blood vessel formation in tissue engineering and regenerative medicine, as well as in treating vascular diseases such as diabetic retinopathy and atherosclerosis.

High Purity

Case Study 1: Xiaoshu Pu, 2023

S1PR1-2.jpg

Fig1. Isorhamnetin suppresses keloid fibroblasts proliferation and metastasis by targeting S1PR1/PI3K/AKT pathway. Western blot assay was performed to detect the protein level of S1PR1.

Case Study 2: Cynthia Weigel, 2023

S1PR1-3.jpg

Fig2. Representative Western blotting images and quantifications of protein levels of KCa2.3, KCa3.1, and S1PR1 in HUVECs upon 0.2 μM S1P stimulation for 24 hours.

S1PR1-5.jpg

Fig2. BHD protects against cerebral ischemic injury through the S1P/S1PR1/PI3K/Akt signaling pathway.

S1PR1 involved in several pathways and played different roles in them. We selected most pathways S1PR1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Fc-epsilon receptor I signaling in mast cells, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with S1PR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)CHRM3;CCBP2;PROKR1;LTB4R;ADRA1B;NMBB;CCL27;GPR68;NMUR1
Fc-epsilon receptor I signaling in mast cellsS1PR1;DOK1;ITK;LAT2;PTPN13
FoxO signaling pathwayBRAF;RAG1;MAPK12;HRASB;INSRB;PTENA;TGFB1A;TGFB2;SOD2
G alpha (i) signalling eventsPNOCB;OXGR1;S1PR3;RLN3;APPA;RGS7;RGR;RGS4;CCR7
GPCR downstream signalingFGD2;PDE10A;PRKCHB;EDN1;HCRT;ADORA1;CCK;RGS18;GPRC6A
GPCR ligand bindingEDN2;EDNRA;TAS2R3;OPN5;OPN1LW;NPB;PRLH;NPS;CGA
GPCRs, OtherMRGPRH;EMR2;GPR88;V1RA8;GPR176;CELSR1;OR10A5;S1PR1;GPR183
Lysosphingolipid and LPA receptorsS1PR1;LPAR2A;LPAR5A;S1PR5B;S1PR3;LPAR2B

S1PR1 has several biochemical functions, for example, G-protein coupled receptor activity, G-protein coupled receptor binding, sphingolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S1PR1 itself. We selected most functions S1PR1 had, and list some proteins which have the same functions with S1PR1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityLPAR5B;PTH1RA;MCHR1;FFAR1;FZD8B;TAAR14G;OLFR10;ADRB2A;GPR78
G-protein coupled receptor bindingUSP20;PACRG;UTS2D;PICK1;GNA15.1;PROK2;NPFF;POMC;RSPO3
sphingolipid bindingS1PR1;TRAF2
sphingosine-1-phosphate receptor activityGPR6;S1PR1;S1PR5A;S1PR4;SPHK2;S1PR3;S1PR2;S1PR5;S1PR3A

S1PR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S1PR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of S1PR1.

S1PR2; SP1; CMSS1

Gene Family

GPCRs

Research Area

Related articles

Al-Jarallah, A; Chen, X; et al. High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists. PLOS ONE 9:-(2014).
Tanaka, K; Hashizume, M; et al. Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 175:172-180(2014).
  • Q&As
  • Reviews

Q&As (5)

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Does the expression of S1PR1 vary among different tissues? 03/09/2020

Yes, the expression of S1PR1 can vary among tissues, and understanding this tissue-specific expression is important for targeted therapeutic approaches.

How does S1PR1 modulation impact the central nervous system? 08/15/2019

Modulation of S1PR1 can influence neuroinflammation and may be relevant in the treatment of neurological disorders, such as multiple sclerosis.

Is S1PR1 involved in the regulation of inflammatory responses? 01/11/2019

Yes, S1PR1 plays a role in modulating inflammatory responses, and targeting it is explored as a strategy in autoimmune and inflammatory diseases.

Can S1PR1 be a therapeutic target for cardiovascular diseases? 04/16/2018

Yes, the involvement of S1PR1 in vascular development and its impact on cardiovascular function make it a potential target for cardiovascular disease treatment.

Are there any side effects associated with drugs targeting S1PR1? 01/31/2018

Drugs targeting S1PR1 may have side effects, including cardiovascular effects and increased susceptibility to infections, which need to be carefully monitored.

Customer Reviews (3)

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Reviews
08/11/2020

    The S1PR1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

    10/07/2018

      One notable advantage of the S1PR1 protein is the outstanding technical support provided by the manufacturer.

      03/04/2017

        One aspect that sets the S1PR1 protein apart is the excellent technical support provided by the manufacturer.

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