Recombinant Human S1PR1 protein

Cat.No. : S1PR1-28462TH
Product Overview : Recombinant Human S1PR1(1 a.a. - 288 a.a.) was expressed in Wheat Germ.
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  • Gene Information
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Description : The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.
Source : Wheat Germ
Species : Human
Form : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Molecular Mass : 42.8 kDa
AA Sequence : MGPTSVPLVKAHRSSVSDYVNYDII VRHYNYTGKLNISADKENSIKLTSV VFILICCFIILENIFVLLTIWKTKK FHRPMYYFIGNLALSDLLAGVAYTA NLLLSGATTYKLTPAQWFLREGSMF VALSASVFSLLAIAIERYITMLKMK LHNGSNNFRLFLLISACWVISLILG GLPIMGWNCISALSSCSTVLPLYHK HYILFCTTVFTLLLLSIVILYCRIY SLVRTRSRRLTFRKNISKASRSSEK SLALLKTVIIVLSVFIACWAPLFIL LLLDVGCKVKTCDILFRAEYFLVLA VLNSGTNPIIYTLTNKEMRRAFIRI MSCCKCPSGDSAGKFKRPIIAGMEF SRSKSDNSSHPQKDEGDNPETIMSS GNVNSSS
Applications : Antibody Production; Functional Study; Compound Screening
Notes : Best use within three months from the date of receipt of this protein. Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens ]
Official Symbol : S1PR1
Synonyms : S1PR1; sphingosine-1-phosphate receptor 1; EDG1, endothelial differentiation, sphingolipid G protein coupled receptor, 1; sphingosine 1-phosphate receptor 1; CD363; D1S3362; edg 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; EDG1; S1P1; ECGF1; EDG-1; CHEDG1; FLJ58121;
Gene ID : 1901
mRNA Refseq : NM_001400
Protein Refseq : NP_001391
MIM : 601974
UniProt ID : P21453
Chromosome Location : 1p21
Pathway : Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Lysosphingolipid and LPA receptors, organism-specific biosystem;
Function : G-protein coupled receptor activity; receptor activity; signal transducer activity; sphingolipid binding; sphingosine-1-phosphate receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Does the expression of S1PR1 vary among different tissues? 03/09/2020

Yes, the expression of S1PR1 can vary among tissues, and understanding this tissue-specific expression is important for targeted therapeutic approaches.

How does S1PR1 modulation impact the central nervous system? 08/15/2019

Modulation of S1PR1 can influence neuroinflammation and may be relevant in the treatment of neurological disorders, such as multiple sclerosis.

Is S1PR1 involved in the regulation of inflammatory responses? 01/11/2019

Yes, S1PR1 plays a role in modulating inflammatory responses, and targeting it is explored as a strategy in autoimmune and inflammatory diseases.

Can S1PR1 be a therapeutic target for cardiovascular diseases? 04/16/2018

Yes, the involvement of S1PR1 in vascular development and its impact on cardiovascular function make it a potential target for cardiovascular disease treatment.

Are there any side effects associated with drugs targeting S1PR1? 01/31/2018

Drugs targeting S1PR1 may have side effects, including cardiovascular effects and increased susceptibility to infections, which need to be carefully monitored.

Customer Reviews (3)

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Reviews
08/11/2020

    The S1PR1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

    10/07/2018

      One notable advantage of the S1PR1 protein is the outstanding technical support provided by the manufacturer.

      03/04/2017

        One aspect that sets the S1PR1 protein apart is the excellent technical support provided by the manufacturer.

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