Recombinant Human S1PR1 protein, His&Flag-tagged

• Cat.No.: S1PR1-1118HFL
• Product Overview: Recombinant Full Length Human S1PR1 protein(NP_001391)(1-382 aa), fused with His and Flag tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His&Flag
• Form: Lyophilized from a 0.2 μm filtered solution in PBS, pH7.4 with 10% glycerin as protectant.
• Protein length: 1-382 aa
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied; 1 month, 2 to 8 °C under sterile conditions after reconstitution; 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: It is recommended to reconstitute the lyophilized powder in sterile water to 100-200 ug/ml, and further dilute with other solvents.It can be stored at 4°C for 2-7 days and should be used up as soon as possible. If not in use for a short time, please store at -20°C.

Gene Information

• Gene Name: S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens ]
• Official Symbol: S1PR1
• Synonyms: S1PR1; sphingosine-1-phosphate receptor 1; EDG1, endothelial differentiation, sphingolipid G protein coupled receptor, 1; sphingosine 1-phosphate receptor 1; CD363; D1S3362; edg 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; EDG1; S1P1; ECGF1; EDG-1; CHEDG1; FLJ58121
• Gene ID: 1901
• mRNA Refseq: NM_001400
• Protein Refseq: NP_001391
• MIM: 601974
• UniProt ID: P21453

Reviews

08/11/2020

The S1PR1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

10/07/2018

One notable advantage of the S1PR1 protein is the outstanding technical support provided by the manufacturer.

03/04/2017

One aspect that sets the S1PR1 protein apart is the excellent technical support provided by the manufacturer.

Q&As

Does the expression of S1PR1 vary among different tissues?

Yes, the expression of S1PR1 can vary among tissues, and understanding this tissue-specific expression is important for targeted therapeutic approaches.

How does S1PR1 modulation impact the central nervous system?

Modulation of S1PR1 can influence neuroinflammation and may be relevant in the treatment of neurological disorders, such as multiple sclerosis.

Is S1PR1 involved in the regulation of inflammatory responses?

Yes, S1PR1 plays a role in modulating inflammatory responses, and targeting it is explored as a strategy in autoimmune and inflammatory diseases.

Can S1PR1 be a therapeutic target for cardiovascular diseases?

Yes, the involvement of S1PR1 in vascular development and its impact on cardiovascular function make it a potential target for cardiovascular disease treatment.

Are there any side effects associated with drugs targeting S1PR1?

Drugs targeting S1PR1 may have side effects, including cardiovascular effects and increased susceptibility to infections, which need to be carefully monitored.