Recombinant Mouse S1pr1 Protein, His-tagged

• Cat.No.: S1pr1-2041M
• Product Overview: Recombinant Mouse S1pr1 Protein (Tyr311-Ser382) with N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 11.6kD
  Accurate Molecular Mass: 16 kDa
• Protein length: Tyr311-Ser382
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: S1pr1 sphingosine-1-phosphate receptor 1 [ Mus musculus (house mouse) ]
• Official Symbol: S1pr1
• Synonyms: S1PR1; sphingosine-1-phosphate receptor 1; sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; lysophospholipid receptor B1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; S1p; Edg1; Lpb1; S1p1; AI849002
• Gene ID: 13609
• mRNA Refseq: NM_007901
• Protein Refseq: NP_031927
• UniProt ID: O08530

Reviews

08/11/2020

The S1PR1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

10/07/2018

One notable advantage of the S1PR1 protein is the outstanding technical support provided by the manufacturer.

03/04/2017

One aspect that sets the S1PR1 protein apart is the excellent technical support provided by the manufacturer.

Q&As

Does the expression of S1PR1 vary among different tissues?

Yes, the expression of S1PR1 can vary among tissues, and understanding this tissue-specific expression is important for targeted therapeutic approaches.

How does S1PR1 modulation impact the central nervous system?

Modulation of S1PR1 can influence neuroinflammation and may be relevant in the treatment of neurological disorders, such as multiple sclerosis.

Is S1PR1 involved in the regulation of inflammatory responses?

Yes, S1PR1 plays a role in modulating inflammatory responses, and targeting it is explored as a strategy in autoimmune and inflammatory diseases.

Can S1PR1 be a therapeutic target for cardiovascular diseases?

Yes, the involvement of S1PR1 in vascular development and its impact on cardiovascular function make it a potential target for cardiovascular disease treatment.

Are there any side effects associated with drugs targeting S1PR1?

Drugs targeting S1PR1 may have side effects, including cardiovascular effects and increased susceptibility to infections, which need to be carefully monitored.