Recombinant Human S1PR1 Protein, GST-tagged

• Cat.No.: S1PR1-4038H
• Product Overview: Human EDG1 full-length ORF ( NP_001391.2, 1 a.a. - 382 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 69.2 kDa
• AA Sequence: MGPTSVPLVKAHRSSVSDYVNYDII VRHYNYTGKLNISADKENSIKLTSV VFILICCFIILENIFVLLTIWKTKK FHRPMYYFIGNLALSDLLAGVAYTA NLLLSGATTYKLTPAQWFLREGSMF VALSASVFSLLAIAIERYITMLKMK LHNGSNNFRLFLLISACWVISLILG GLPIMGWNCISALSSCSTVLPLYHK HYILFCTTVFTLLLLSIVILYCRIY SLVRTRSRRLTFRKNISKASRSSEK SLALLKTVIIVLSVFIACWAPLFIL LLLDVGCKVKTCDILFRAEYFLVLA VLNSGTNPIIYTLTNKEMRRAFIRI MSCCKCPSGDSAGKFKRPIIAGMEF SRSKSDNSSHPQKDEGDNPETIMSS GNVNSSS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens ]
• Official Symbol: S1PR1
• Synonyms: S1PR1; sphingosine-1-phosphate receptor 1; EDG1, endothelial differentiation, sphingolipid G protein coupled receptor, 1; sphingosine 1-phosphate receptor 1; CD363; D1S3362; edg 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; EDG1; S1P1; ECGF1; EDG-1; CHEDG1; FLJ58121
• Gene ID: 1901
• mRNA Refseq: NM_001400
• Protein Refseq: NP_001391
• MIM: 601974
• UniProt ID: P21453

Reviews

08/11/2020

The S1PR1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

10/07/2018

One notable advantage of the S1PR1 protein is the outstanding technical support provided by the manufacturer.

03/04/2017

One aspect that sets the S1PR1 protein apart is the excellent technical support provided by the manufacturer.

Q&As

Does the expression of S1PR1 vary among different tissues?

Yes, the expression of S1PR1 can vary among tissues, and understanding this tissue-specific expression is important for targeted therapeutic approaches.

How does S1PR1 modulation impact the central nervous system?

Modulation of S1PR1 can influence neuroinflammation and may be relevant in the treatment of neurological disorders, such as multiple sclerosis.

Is S1PR1 involved in the regulation of inflammatory responses?

Yes, S1PR1 plays a role in modulating inflammatory responses, and targeting it is explored as a strategy in autoimmune and inflammatory diseases.

Can S1PR1 be a therapeutic target for cardiovascular diseases?

Yes, the involvement of S1PR1 in vascular development and its impact on cardiovascular function make it a potential target for cardiovascular disease treatment.

Are there any side effects associated with drugs targeting S1PR1?

Drugs targeting S1PR1 may have side effects, including cardiovascular effects and increased susceptibility to infections, which need to be carefully monitored.