Recombinant Full Length Human Sphingosine 1-Phosphate Receptor 1(S1Pr1) Protein, His-Tagged

• Cat.No.: RFL1995HF
• Product Overview: Recombinant Full Length Human Sphingosine 1-phosphate receptor 1(S1PR1) Protein (P21453) (1-382aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-382)
• AA Sequence: MGPTSVPLVKAHRSSVSDYVNYDII VRHYNYTGKLNISADKENSIKLTSV VFILICCFII LENIFVLLTIWKTKKFHRPMYYFIG NLALSDLLAGVAYTANLLLSGATTY KLTPAQWFLR EGSMFVALSASVFSLLAIAIERYIT MLKMKLHNGSNNFRLFLLISACWVI SLILGGLPIM GWNCISALSSCSTVLPLYHKHYILF CTTVFTLLLLSIVILYCRIYSLVRT RSRRLTFRKN ISKASRSSEKSLALLKTVIIVLSVF IACWAPLFILLLLDVGCKVKTCDIL FRAEYFLVLA VLNSGTNPIIYTLTNKEMRRAFIRI MSCCKCPSGDSAGKFKRPIIAGMEF SRSKSDNSSH PQKDEGDNPETIMSSGNVNSSS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: S1PR1
• Synonyms: S1PR1; CHEDG1; EDG1; Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD antigen CD363
• UniProt ID: P21453

Gene Information

• Gene Name: S1PR1
• Synonyms: S1PR1; CHEDG1; EDG1; Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD antigen CD363
• UniProt ID: P21453

Reviews

08/11/2020

The S1PR1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

10/07/2018

One notable advantage of the S1PR1 protein is the outstanding technical support provided by the manufacturer.

03/04/2017

One aspect that sets the S1PR1 protein apart is the excellent technical support provided by the manufacturer.

Q&As

Does the expression of S1PR1 vary among different tissues?

Yes, the expression of S1PR1 can vary among tissues, and understanding this tissue-specific expression is important for targeted therapeutic approaches.

How does S1PR1 modulation impact the central nervous system?

Modulation of S1PR1 can influence neuroinflammation and may be relevant in the treatment of neurological disorders, such as multiple sclerosis.

Is S1PR1 involved in the regulation of inflammatory responses?

Yes, S1PR1 plays a role in modulating inflammatory responses, and targeting it is explored as a strategy in autoimmune and inflammatory diseases.

Can S1PR1 be a therapeutic target for cardiovascular diseases?

Yes, the involvement of S1PR1 in vascular development and its impact on cardiovascular function make it a potential target for cardiovascular disease treatment.

Are there any side effects associated with drugs targeting S1PR1?

Drugs targeting S1PR1 may have side effects, including cardiovascular effects and increased susceptibility to infections, which need to be carefully monitored.