SAE1 Protein


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Official Full Name SUMO1 activating enzyme subunit 1
Background The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Synonyms SAE1; SUMO1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; activator Of sumo 1; AOS1; FLJ3091; Sua1; activator of SUMO1; SUMO-1 activating enzyme subunit 1; sentrin/SUMO-activating protein AOS1; SUMO-1 activating enzyme E1 N subunit; ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; UBLE1A; HSPC140
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SAE1-104H Recombinant Human SAE1/SAE2 E.coli His
    Human SAE1-170H Recombinant Human SAE1/UBA2, GST/His-tagged E.coli GST/His
    Human SAE1-1459H Recombinant Human SUMO1 Activating Enzyme Subunit 1, T7-tagged Human N/A
    Human SAE1-2499H Recombinant Human SAE1, GST-tagged E.coli GST
    Human SAE1-255H Recombinant Human SAE1, GST-tagged Sf9 Insect Cell GST
    Human SAE1-29262TH Recombinant Human SAE1, His-tagged E.coli His
    Human SAE1-508H Recombinant Human SAE1, None tagged Insect Cell His
    Human SAE1-59H Recombinant Human SUMO1 Activating Enzyme Subunit 1, His-tagged E.coli His
    Human SAE1-61H Recombinant Human SUMO1 Activating Enzyme Subunit 1 E.coli N/A
    Human SAE1-691H Recombinant Human SUMO1 Activating Enzyme Subunit 1, His-tagged E.coli His
    Human SAE1-8623H Recombinant Human SAE1, His-GST tagged Insect Cell His/GST
    Mouse SAE1-14641M Recombinant Mouse SAE1 Protein Mammalian Cell His
    Rat SAE1-5223R Recombinant Rat SAE1 Protein Mammalian Cell His
    Zebrafish SAE1-292Z Recombinant Zebrafish SAE1 Mammalian Cell His
    Human SAE1-001HCL Recombinant Human SAE1 cell lysate Insect Cell N/A
    Human SAE1-4889H Recombinant Human SAE1 protein, GST-tagged E.coli GST
    Human SAE1-1072H Recombinant Human SAE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SAE1-222H Recombinant Human SAE1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Sae1-5678M Recombinant Mouse Sae1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SAE1 involved in several pathways and played different roles in them. We selected most pathways SAE1 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins ADAMTS15; SLC35A1; GRPEL1; NSMCE4A; ZNF408; DOHH; IGFBP5; SEC63; NOP56; NAPAB
    Post-translational protein modification SCFD1; EID3; ZNF408; KCNA6; SPON1B; NAPAA; ST8SIA3; SLC35A1; NEU4; THSD7A
    Processing and activation of SUMO SENP1; SAE1; UBA2; SENP5
    SUMO is conjugated to E1 (UBA2:SAE1) SAE1; UBA2
    SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1; UBA2
    SUMOylation SCMH1; RING1; PHC1; UBA2; SENP5; SMC5; NSMCE4A; RNF2; CBX8; PHC3
    Ubiquitin mediated proteolysis HUWE1; UBE2D1B; ANAPC1; CDC27; UBE2M; RHOBTB2; UBE2IB; UBE2KB; SMURF2; WWP2

    SAE1 has several biochemical functions, for example, ATP-dependent protein binding, contributes_to SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAE1 itself. We selected most functions SAE1 had, and list some proteins which have the same functions with SAE1. You can find most of the proteins on our site.

    Function Related Protein
    ATP-dependent protein binding STX1A; MYO5A; DNAJC5; SAE1; DDX39B; PRNP
    contributes_to SUMO activating enzyme activity SAE1
    enzyme activator activity ARL1; SLX4; MMP16; UBA2; ALDH1A2; ALOX5AP; RICTOR; DBF4; MMP15; CTSA
    protein C-terminus binding LIG4; PQBP1; CEP135; ABL1; XRCC5; SNX17; PCGF1; KCNJ11; MKI67; CLIC6
    protein binding CHAF1A; KIAA0101; PSME3; AKIP1; TRMT12; TDP2; PPP1CB; PCNP; XPA; TFAP2C
    protein heterodimerization activity KCNIP1; KCNK9; ATF2; EFHA1; SMAD2; POLA2; HIST3H2A; HIST1H2AL; Defa-rs7; YWHAE
    ubiquitin activating enzyme activity SAE1; UBA1; ATG7; UBA7; UBE1Y1; UBA6

    SAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAE1.

    UBA2; UBE2I; TP53; 40068515; SUMO3; SUMO1; FKBP4; IKBKE; CYP1B1; TRAF6; IL3RA; PTK2; truB

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