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SAE1

  • Official Full Name

    SUMO1 activating enzyme subunit 1

  • Overview

    The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
  • Synonyms

    SAE1; SUMO1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; activator Of sumo 1; AOS1; FLJ3091; Sua1; activator of SUMO1; SUMO-1 activating enzyme subunit 1; sentrin/SUMO-activating protein AOS1; SUMO-1 activating enzyme E1 N subunit; ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; UBLE1A; HSPC140;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SAE1-170H Active Recombinant Human SAE1/UBA2, GST/His-tagged E.coli GST/His
Human SAE1-104H Active Recombinant Human SAE1/SAE2 E.coli His
Human SAE1-255H Recombinant Human SAE1, GST-tagged Sf9 Insect Cell GST
Human SAE1-61H Recombinant Human SUMO1 Activating Enzyme Subunit 1 E.coli N/A
Human SAE1-8623H Recombinant Human SAE1 protein(Met1-Lys346), His&GST-tagged Insect Cells N-His&GST Met1-Lys346
Human SAE1-2499H Recombinant Human SAE1, GST-tagged E.coli GST 0-207aa
Human SAE1-59H Recombinant Human SUMO1 Activating Enzyme Subunit 1, His-tagged E.coli His
Human SAE1-691H Recombinant Human SUMO1 Activating Enzyme Subunit 1, His-tagged E.coli His
Human SAE1-1459H Recombinant Human SUMO1 Activating Enzyme Subunit 1, T7-tagged Human N/A
Human SAE1-29262TH Recombinant Human SAE1, His-tagged E.coli His
Human SAE1-508H Recombinant Human SAE1, None tagged Insect Cell His
Human SAE1-001HCL Recombinant Human SAE1 cell lysate Insect Cell N/A
Human SAE1-222H Recombinant Human SAE1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SAE1-4889H Recombinant Human SAE1 protein, GST-tagged E.coli GST 1-346aa
Human SAE1-1072H Recombinant Human SAE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SAE1-436HFL Active Recombinant Full Length Human SAE1 Protein, C-Flag-tagged Mammalian cells Flag
Human SAE1-1949H Recombinant Human SAE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SAE1-1949H-B Recombinant Human SAE1 Protein Pre-coupled Magnetic Beads HEK293
Human SAE1-1985H Recombinant Human SAE1 protein Insect Cells N/A Met1-Lys346
Mouse SAE1-14641M Recombinant Mouse SAE1 Protein Mammalian Cell His
Mouse SAE1-7883M Recombinant Mouse SAE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sae1-5678M Recombinant Mouse Sae1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SAE1-7883M-B Recombinant Mouse SAE1 Protein Pre-coupled Magnetic Beads HEK293
Rat SAE1-5223R Recombinant Rat SAE1 Protein Mammalian Cell His
Rat SAE1-4882R Recombinant Rat SAE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SAE1-4882R-B Recombinant Rat SAE1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SAE1-292Z Recombinant Zebrafish SAE1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SAE1 Related Research Area

SAE1 involved in several pathways and played different roles in them. We selected most pathways SAE1 participated on our site, such as Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of proteinsOTOP2;SERP1;SPON1;MUCL1;GAS6;RNF2;PPP6C;CHCHD4;PFDN2
Post-translational protein modificationADAMTSL4;ADAMTS15;OTOP2;SCFD1;DPH5;TRAPPC4;TRAPPC6A;TRAPPC10;ATPBD4
Processing and activation of SUMOSENP1;UBA2;SAE1;SENP5
SUMO is conjugated to E1 (UBA2:SAE1)UBA2;SAE1
SUMO is transferred from E1 to E2 (UBE2I, UBC9)UBA2;SAE1
SUMOylationSMC6;UBA2;SCMH1;RNF2;EID3;NSMCE1;PHC3;NSMCE4A;RING1
Ubiquitin mediated proteolysisCDH1-A;KLHL13;KEAP1B;UBE2L3A;UBA7;CUL5;ANAPC1;NEDD4;ANAPC13

SAE1 has several biochemical functions, for example, ATP-dependent protein binding, contributes_to SUMO activating enzyme activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAE1 itself. We selected most functions SAE1 had, and list some proteins which have the same functions with SAE1. You can find most of the proteins on our site.

Function Related Protein
ATP-dependent protein bindingDDX39B;STX1A;MYO5A;PRNP;SAE1;DNAJC5
contributes_to SUMO activating enzyme activity
enzyme activator activityMMP16;APOA5;GTF3C4;DCP1A;MMP17;MMP15;PITRM1;TIMP2;SLX4
protein C-terminus bindingLCK;KCNJ11;CTNNB1;NPAT;ERBB2;ATP2A2;OPRL1;MLLT4;SNF8
protein bindingGEMIN4;FBXL12;CSF1;PBLD;MAPK8;NDUFS7;TXNRD3;ZFP335;CASP2
protein heterodimerization activityDMRTA2;ALX1;SCGB2A1;ANO9A;NPM1;BCL2L10;SOX9;BRAF;HIST1H2A9
ubiquitin activating enzyme activityUBA6;UBA7;SAE1;ATG7;UBE1Y1;UBA1

SAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAE1.

UBA2; UBE2I; TP53; 40068515; SUMO3; SUMO1; FKBP4; IKBKE; CYP1B1; TRAF6; IL3RA; PTK2; truB

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