Recombinant Human SAE1, His-tagged SAE1-29262TH

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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Recombinant Human SAE1, His-tagged

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Cat.No. : SAE1-29262TH Optional Service: Optional requirements on this protein
Product Overview : Recombinant fragment, corresponding to amino acids 18-346 of Human SAE1 with N terminal His tag; 329 amino acids, Predicted Mwt 37kDa.
Description : Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al.
Conjugation : HIS
Source : E. coli
Tissue specificity : Expression level increases during S phase and drops in G2 phase (at protein level).
Form : Lyophilised:Reconstitute with 135 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : QYDRQIRLWG LEAQKRLRAS RVLLVGLKGL GAEIAKNLIL AGVKGLTMLD HEQVTPEDPG AQFLIRTGSV GRNRAEASLE RAQNLNPMVD VKVDTEDIEK KPESFFTQFD AVCLTCCSRD VIVKVDQICH KNSIKFFTGD VFGYHGYTFA NLGEHEFVEE KTKVAKVSQG VEDGPDTKRA KLDSSETTMV KKKVVFCPVK EALEVDWSSE KAKAALKRTT SDYFLLQVLL KFRTDKGRDP SSDTYEEDSE LLLQIRNDVL DSLGISPDLL PEDFVRYCFS EMAPVCAVVG GILAQEIVKA LSQRDPPHNN FFFFDGMKGN GIVECLGPK
Sequence Similarities : Belongs to the ubiquitin-activating E1 family.
Gene Name : SAE1 SUMO1 activating enzyme subunit 1 [ Homo sapiens ]
Official Symbol : SAE1
Synonyms : SAE1; SUMO1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; activator Of sumo 1; AOS1; FLJ3091; Sua1;
Gene ID : 10055
mRNA Refseq : NM_001145713
Protein Refseq : NP_001139185
MIM : 613294
Uniprot ID : Q9UBE0
Chromosome Location : 19q13.32
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem;
Function : ATP-dependent protein binding; contributes_to SUMO activating enzyme activity; enzyme activator activity; ligase activity; nucleotide binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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