SELE

  • Official Full Name

    Selectin E

  • Overview

    E-selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1) belongs to the selectin family of adhesion molecules. Together with LECAM-1 (L-selectin) and GMP-140 (P-selectin), E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. Molecular structure: The extracellular part of all selectins consists of an aminoterminal c-type lectin domain, which specifically binds to carbohydrate ligands. This is followed by an EGF-like domain, and, in the case of E-selectin, by 6 short consensus repeats. The transmembrane portion of the molecule is followed by a short cytoplasmic tail. Selectins provide the first, loose contacts of polymorphonuclear cells with the endothelium in areas of inflammation. The binding partner for E-selectin contains sialyl LewisX oligosaccharide or lactosaminoglycans that contain either sialic acid or fucose. E-selectin is expressed on cytokine-activated endothelial cells, and promotes the adhesion of leukocytes to the endothelium. This initial binding event is a prerequisite for the activation of the immune cells via inflammatory mediators. In contrast to GMP-140, E-selectin is maximally expressed 2-4 hours after cell activation. During the following 24-48 hours E-selectin is shed from the cytoplasmic membrane into the circulation. The circulating form of this selectin attracts neutrophils and activates the 2- integrins in preparing the cells for migration. Soluble E-selectin levels could provide insights into several pathologies, including allergic reactions, septic shock, vascular infection and inflammatory bowel disease.
  • Synonyms

    RP1-117P20.2; CD62E; ELAM; ELAM1; ESEL; LECAM2; CD62 antigen-like family member E; E-selectin; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • Insects cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • 8His
  • His
  • DYKDDDDK
  • Fc
  • Fc|His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SELE-79H Active Recombinant Human SELE CHO N/A
Human SELE-2638H Recombinant Human Selectin E CHO N/A
Human SELE-189H Recombinant Human SELE Protein, His-tagged HEK293 His
Human SELE-660H Recombinant Human SELE, Fc-His tagged Human Cell Fc/His
Human SELE-117H Recombinant Human Selectin E E.coli N/A
Human SELE-267H Recombinant Human selectin E, His-tagged E.coli His
Human SELE-661H Recombinant Human SELE protein, Fc-tagged HEK293 human/IgG1/Fc 535
Human SELE-2242H Recombinant Human SELE protein, His-tagged HEK293 His Trp22-Pro556
Human SELE-608H Recombinant Human SELE protein, His & T7-tagged E.coli His/T7 Asp108~Asn238 (Accession # P16581)
Human SELE-27883TH Recombinant Human SELE, His-tagged E.coli His
Human SELE-2992HCL Recombinant Human SELE cell lysate Human Cell N/A
Human SELE-1222H Recombinant Human SELE Protein, His-tagged HEK293F N-His Asp155-Ile707
Human SELE-597H Recombinant Human SELE Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SELE-151H Recombinant Human SELE Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human SELE-2416H Recombinant Human SELE Protein (Trp22-Pro556), C-His tagged Mammalian cells C-His Trp22-Pro556
Human SELE-1106H Recombinant Human SELE Protein (Trp22-Ser371), N-His tagged E.coli N-His Trp22-Ser371
Human SELE-581HB Recombinant Human SELE protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Trp22-Pro556
Human SELE-5083H Recombinant Human SELE Protein (Met1-Pro556), C-His tagged Mammalian cells C-His Met1-Pro556
Human CD62E-42H Recombinant Human CD62E Protein, C-8His tagged, Biotinylated HEK293 C-8His W22-P556
Human SELE-581H Recombinant Human SELE protein, His-Avi-tagged HEK293 His-Avi Trp22-Pro556
Human SELE-215H Recombinant Human SELE Protein, His-tagged HEK293 His
Human SELE-210H Recombinant Human SELE Protein, Fc-tagged HEK293 Fc 610
Human SELE-128H Recombinant Human SELE Protein, His-tagged E.coli His
Human SELE-209H Recombinant Human SELE Protein, His-tagged HEK293 His 610
Human SELE-1282H Active Recombinant Human SELE protein, His-tagged HEK293 His Trp22-Pro556
Human SELE-1819H Recombinant Human SELE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SELE-05H Active Recombinant Human SELE Protein, His-tagged Insects cells His
Mouse SELE-182M Recombinant Mouse Sele, LEVLFQ tagged Human Cell His
Mouse Sele-8680M Recombinant Mouse Sele protein(Met1-Pro564), His-tagged HEK293 C-His Met1-Pro564
Mouse SELE-223M Recombinant Mouse Sele, Fc tagged Human Cell Fc/His
Mouse Sele-1720M Recombinant Mouse Selectin, Endothelial Cell, Fc-His Mammalian cells Fc/His
Mouse SELE-845MCL Recombinant Mouse SELE cell lysate Human Cell N/A
Mouse Sele-2048M Recombinant Mouse Sele Protein, His-tagged E.coli N-His Trp22-Leu371
Mouse Sele-164M-B Recombinant Mouse Sele Protein Pre-coupled Magnetic Beads HEK293
Mouse SELE-839M Recombinant Mouse SELE Protein (Met1-Pro564) HEK293 N/A Met1-Pro564
Mouse Sele-5755M Recombinant Mouse Sele Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Sele-1972M Active Recombinant Mouse Sele protein, hFc-tagged HEK293 hFc Met1-Pro564
Mouse Sele-164M Recombinant Mouse Sele Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SELE-292R Recombinant Rat Sele, Fc tagged Human Cell His
Rat Sele-1791R Recombinant Rat Selectin E Mammalian cells N/A
Rat Sele-4093R Active Recombinant Rat Sele protein(Met1-Pro494), His-tagged HEK293 C-His Met1-Pro494
Rat SELE-5307R Recombinant Rat SELE Protein Mammalian Cell His
Rat SELE-960RCL Recombinant Rat SELE cell lysate Human Cell N/A
Rat Sele-6390R Recombinant Rat Sele Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SELE-1977R Active Recombinant Rat SELE protein, hFc-tagged HEK293 hFc Met1-Pro494
Rat Sele-6390R-B Recombinant Rat Sele Protein Pre-coupled Magnetic Beads HEK293
Rabbit SELE-612R Recombinant Rabbit SELE protein, His & T7-tagged E.coli His/T7 Ala30~Thr142
Rabbit SELE-5514R Recombinant Rabbit SELE protein, His-tagged Yeast His 24-495aa
Dog SELE-607D Recombinant Dog SELE protein, His & T7-tagged E.coli His/T7 Trp23~Val240
Bos taurus (Bovine) RFL22559BF Recombinant Full Length Bovine E-Selectin(Sele) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-485)
Canis lupus familiaris (Dog) (Canis familiaris) RFL6137CF Recombinant Full Length Dog E-Selectin(Sele) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-611)
Cynomolgus SELE-1202C Active Recombinant Cynomolgus SELE Protein, Fc-tagged HEK293 Fc Met1-Pro556
Cynomolgus Monkey SELE-94C Recombinant Cynomolgus SELE, His tagged Human Cell His
Cynomolgus Monkey SELE-1099CCL Recombinant Cynomolgus SELE cell lysate Human Cell N/A
Homo sapiens (Human) RFL35126HF Recombinant Full Length Human E-Selectin(Sele) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-610)
Zebrafish SELE-7081Z Recombinant Zebrafish SELE Mammalian Cell His
Pig SELE-609P Recombinant Pig SELE protein, His & GST-tagged E.coli His/GST Glu260~Cys420 (Accession # P98110)
Pig SELE-610P Recombinant Pig SELE protein, His & GST-tagged E.coli His/GST Trp23~Tyr140 (Accession # P98110)
Pig SELE-611P Recombinant Pig SELE protein, His & GST-tagged E.coli His/GST Ala142~His245 (Accession # P98110)
Pig SELE-6109P Recombinant Pig SELE protein E.coli N/A 23-429aa
Pig SELE-800P Recombinant Pig SELE Protein (23-429 aa), GST-tagged E.coli GST 23-429 aa
Pig SELE-5513P Recombinant Pig SELE protein, His-tagged Yeast His 23-429aa
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is SELE protein?

SELE (selectin E) gene is a protein coding gene which situated on the long arm of chromosome 1 at locus 1q24. SELE is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. SELE consists of an N-terminal type 1 lectin domain, an EGF-like domain, 6 sushi (CCP/SCR) domains, a transmembrane sequence, and a short cytoplasmic domain.

What is the function of SELE protein?

During inflammation, SELE plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of SELE on endothelial cells of nearby blood vessels. SELE mediates the adhesion of tumor cells to endothelial cells, by binding to SELE ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of SELE may be elevated in subjects with a variety of pathological conditions.

SELE related Signaling pathways

Multiple signaling pathways are involved in the regulation of SELE expression. One of the major pathways is the nuclear factor-kappa B (NF-κB) pathway, which is activated in response to various pro-inflammatory stimuli. Another important pathway involved in SELE regulation is the mitogen-activated protein kinase (MAPK) pathway. Furthermore, cytokines and chemokines released during inflammation, such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), can also stimulate SELE expression through their respective signaling pathways.

SELE Related Diseases

Inflammatory bowel disease (IBD): SELE has been shown to be upregulated in patients with IBD, including Crohn's disease and ulcerative colitis. Cardiovascular diseases: SELE has been implicated in the development and progression of cardiovascular diseases, such as atherosclerosis, coronary artery disease, and ischemic stroke. Leukocyte adhesion deficiency Type I: This is a rare genetic disorder in which white blood cells cannot properly adhere to the lining of blood vessels due to a lack of the SELE protein. Sepsis: Sepsis is a life-threatening condition characterized by systemic inflammation in response to severe infection. Rheumatoid arthritis (RA): SELE is involved in the recruitment of leukocytes to the synovium, contributing to chronic inflammation in the joints of individuals with RA.

SELE-7.jpg

Fig1. E-selectin levels in sickle cell disease patients with and without retinopathy.

Bioapplications of SELE

SELE plays a critical role in various biological processes, including inflammation, immune response, cancer metastasis, and cardiovascular diseases. Understanding the signaling pathways involved in SELE expression and function can have important implications for therapeutic interventions and drug targeting strategies in these diseases.

High Purity

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SELE-2.jpg

Fig2. SDS-PAGE (SELE-661H)

Case Study 1: Chae Min Lee, 2024

SELE-3.jpg

Fig1. Volcano plot illustrates several angiogenic process-related genes were enriched in ACKR1-high TECs.

Case Study 2: Sidra Shahid, 2022

SELE-4.jpg

Fig2. Establishment of inflammatory phenotype in HUVECs. Bar graph showing relative mRNA levels of SELE, VCAM-I, and IL6 after normalization to housekeeping gene GAPDH, in DMSO control and TNF-α treated cells.

SELE-6.jpg

Fig2. Proposed mechanism to explain the effect of ginkgo extracts on signaling cascade involved in E-selectin regulation.

SELE involved in several pathways and played different roles in them. We selected most pathways SELE participated on our site, such as Cell adhesion molecules (CAMs), TNF signaling pathway, African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SELE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)ITGB1;PVRL1;PECAM1;ITGA6;ICAM2;CNTN1;NLGN2B;CLDN16;PTPRF
TNF signaling pathwayPIK3R2;CREB3L3;PIK3R3;CCL2;TRADD;IKBKG;PIK3CB;TNFAIP3;RPS6KA4
African trypanosomiasisHBB-B1;HBA2;IL6;IL18;PRKCB;FAS;THOP1;FASLG;TNF
MalariaTHBS2;MYD88;GYPC;TGFB3;THBS3;TGFB2;HGF;HBB-B1;LRP1

SELE has several biochemical functions, for example, oligosaccharide binding, phospholipase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SELE itself. We selected most functions SELE had, and list some proteins which have the same functions with SELE. You can find most of the proteins on our site.

Function Related Protein
oligosaccharide bindingSELE;DCBLD1;CHID1;RS1A;LOXL2;SELP
phospholipase bindingSELE;Pla2r1;NEFL;PARK2;PDPK1;ARHGAP6;DGKQ;LMNB1;SNCA
protein bindingSLC25A6;VCAN;CD28;TCOF1;GHR;LZTS2;BAHD1;DROSHA;WDR12
sialic acid bindingL1CAM;ADIPOQ;ST8SIA2;Siglece;SELP;FCN1;AGRN;ST8SIA3;SELE
transmembrane signaling receptor activityNFAM1;SIGLEC8;EBP;IL4R.1;EMR4;NRXN1;LGR5;ADCYAP1R1A;NCR2

SELE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SELE here. Most of them are supplied by our site. Hope this information will be useful for your research of SELE.

PTPN11

Research Area

Related articles

Chukkapalli, SS; Rivera, MF; et al. Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE(-/-) Mice Causally Links Periodontal Disease and Atherosclerosis. INFECTION AND IMMUNITY 82:1959-1967(2014).
Przybyla, BD; Shafirstein, G; et al. Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma. INTERNATIONAL JOURNAL OF ONCOLOGY 44:600-608(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is there a diagnostic test to measure SELE levels in patients? 11/30/2021

Some diagnostic tests can measure SELE levels in the blood, providing insights into the inflammatory status of an individual.

Can SELE protein be involved in cancer progression? 01/18/2020

Emerging research suggests a potential role of SELE in cancer metastasis, making it a target for investigation in cancer therapy.

Are there any genetic factors influencing SELE expression? 01/05/2018

Genetic variations can influence SELE expression, contributing to individual differences in inflammatory responses.

How does SELE protein interact with circulating immune cells? 01/09/2017

SELE binds to specific receptors on immune cells, facilitating their adhesion to endothelial cells and promoting their migration to inflammatory sites.

Can targeting SELE protein be a potential strategy for anti-inflammatory therapies? 08/05/2016

Yes, drugs designed to modulate SELE activity are being explored as potential anti-inflammatory agents.

Customer Reviews (3)

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Reviews
11/26/2020

    With its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.

    09/08/2019

      In addition to its outstanding quality, the SELE Protein exhibits exceptional stability during storage and usage.

      06/16/2019

        Its ability to maintain structural integrity and stability ensures accurate imaging, enabling me to gain deeper insights into the three-dimensional organization and interactions of the proteins under investigation.

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