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Official Full Name single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Background Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.
Synonyms SIGIRR; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single Ig IL-1-related receptor; single immunoglobulin domain IL1R1 related; TIR8; Single immunoglobulin domain containing IL1R related protein; Toll/interleukin 1 receptor 8; Ig IL1 related receptor; MGC110992; SIGIR_HUMAN; Single Ig IL 1 related receptor; Single Ig IL-1R-related molecule; Single Ig IL1R Related Molecule; Single immunoglobulin and toll interleukin 1 receptor (TIR) domain; Single immunoglobulin and toll interleukin 1 receptor domain; Single immunoglobulin domain-containing IL1R-related protein; TIR 8; Toll/interleukin-1 receptor 8; OTTHUMP00000229641; OTTHUMP00000229642; OTTHUMP00000229643; OTTHUMP00000229644; OTTHUMP00000229645; single immunoglobulin
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NSO
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIGIRR-1091HCL Recombinant Human SIGIRR cell lysate Human Cell N/A
    Human SIGIRR-1681H Recombinant Human SIGIRR NSO N/A
    Human SIGIRR-1685H Recombinant Human SIGIRR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SIGIRR-1950H Recombinant Human SIGIRR protein, His-tagged E.coli His
    Human SIGIRR-2422H Recombinant Human SIGIRR, Fc Chimera Human Cell Fc
    Human SIGIRR-2708H Recombinant Human SIGIRR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SIGIRR-28784TH Recombinant Human SIGIRR, Fc-tagged HEK293 Fc
    Human SIGIRR-28785TH Recombinant Human SIGIRR, His-tagged E.coli His
    Human SIGIRR-3956H Recombinant Human SIGIRR, His tagged Human Cell His
    Human SIGIRR-422H Recombinant Human SIGIRR, Fc tagged Human Cell His
    Human SIGIRR-674H Recombinant Human SIGIRR, Fc-tagged, Biotinylated Human Cell Fc
    Mouse Sigirr-1951M Recombinant Mouse Sigirr protein, His & GST-tagged E.coli His/GST
    Mouse SIGIRR-2054M Recombinant Mouse SIGIRR Protein (1-117 aa), His-tagged Yeast His
    Mouse SIGIRR-2773MCL Recombinant Mouse SIGIRR cell lysate Human Cell N/A
    Mouse Sigirr-501M Recombinant Mouse Sigirr NSO N/A
    Mouse Sigirr-5875M Recombinant Mouse Sigirr Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse SIGIRR-772M Recombinant Mouse SIGIRR, Fc-His tagged Human Cell Fc/His
    Rat Sigirr-1952R Recombinant Rat Sigirr protein, His-tagged E.coli His
    Rat SIGIRR-5400R Recombinant Rat SIGIRR Protein Mammalian Cell His
    Chicken SIGIRR-4376C Recombinant Chicken SIGIRR Mammalian Cell His
    Zebrafish SIGIRR-5670Z Recombinant Zebrafish SIGIRR Mammalian Cell His

    sigirr involved in several pathways and played different roles in them. We selected most pathways sigirr participated on our site, such as Activated TLR4 signalling, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with sigirr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling ALCAMB; DUSP7; TIRAP; DHX9; SIGIRR; CREB1; CHST13; ATF2; MAP3K8; JUN
    Immune System B2ML; CMTM2A; USP18; CD160; AMICA1; NCKAP1; DEFA1; KPNA3; AP1G1; EIF4E3
    Innate Immune System KIR3DS1; CD180; ALCAMB; NCKAP1; POLR3F; LGALS3; TLR6; DEFB129; SUGT1; BTR12
    MyD88:Mal cascade initiated on plasma membrane SIGIRR; IRAK3
    Toll Like Receptor 2 (TLR2) Cascade SIGIRR
    Toll Like Receptor 4 (TLR4) Cascade CD180; SIGIRR; LY86
    Toll Like Receptor TLR1:TLR2 Cascade SIGIRR
    Toll Like Receptor TLR6:TLR2 Cascade SIGIRR

    sigirr has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sigirr itself. We selected most functions sigirr had, and list some proteins which have the same functions with sigirr. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PARP4; CAND2; CRY2; STRADB; EPB41B; HIP1R; MIF; SHROOM2; DDB1; EHHADH

    sigirr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sigirr here. Most of them are supplied by our site. Hope this information will be useful for your research of sigirr.

    RPN1; ENO2; yhdI

    Bulau, AM; Nold, MF; et al. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2650-2655(2014).
    Trevisi, E; Amadori, M; et al. Evaluation of innate immune responses in bovine forestomachs. RESEARCH IN VETERINARY SCIENCE 96:69-78(2014).

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