|Official Full Name||SMAD family member 5|
|Background||The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]|
|Synonyms||SMAD5; SMAD family member 5; DWFC; JV5-1; MADH5; mothers against decapentaplegic homolog 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; MAD, mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SMAD5 involved in several pathways and played different roles in them. We selected most pathways SMAD5 participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|TGF-beta signaling pathway||RBL1; MAPK1; ZFYVE16; BMP6; NDR1; ROCK2B; LFT2; TGFBR1A; BMP5; SMAD5|
|Signaling pathways regulating pluripotency of stem cells||NRAS; PAX6; SOX2; FZD6; KLF4; SMAD9; FZD3; PCGF1; FZD1; HOXB1|
SMAD5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD5 itself. We selected most functions SMAD5 had, and list some proteins which have the same functions with SMAD5. You can find most of the proteins on our site.
|DNA binding||IRF2A; SOX19B; ZBED4; NEUROD6A; ZFP526; EXO5; MIER1B; DNAJC1; ZNF7; LHX1B|
|RNA polymerase II core promoter sequence-specific DNA binding||STAT5A; FOS; TCF7L2; NSD1; MAZ; ZFP335; WBP2; GATA3; SP3; TBR1|
|metal ion binding||ZNF566; NUBP2; MAP2K2; ASAP2; CALUA; FTH1A; ZFP518A; B3GAT2; OASL2; LRRK1|
|protein binding||XAB2; PRDM10; SPTAN1; DCBLD2; P2RX4; SOX9A; CD247; LAMP1; DCTN2; MMP15|
|transcription factor activity, sequence-specific DNA binding||ESR2A; KLF12; DEAF1; TCF3B; KDM5A; NFE2L1B; ZNF146; ZNF217; SMAD5; TCF4|
|ubiquitin protein ligase binding||HDAC6; MUL1; CUL4A; ATP6V0C; RPA2; TNFRSF1B; LTBR; MAP1LC3C; CD40; UBOX5|
SMAD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD5.