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SMAD5

Official Full Name

SMAD family member 5
Overview

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Synonyms

SMAD5; SMAD family member 5; DWFC; JV5-1; MADH5; mothers against decapentaplegic homolog 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; MAD, mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Insect Cell
Insect Cells
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SMAD5-31194TH	Recombinant Human SMAD5	E.coli	N/A		Inquiry
Human	SMAD5-2800H	Recombinant Human SMAD5, GST-tagged	E.coli	GST	C-term-305aa	$319 / 25ug
Human	SMAD5-1493H	Recombinant Human SMAD Family Member 5, GST-tagged	E.coli	GST		Inquiry
Human	SMAD5-162H	Recombinant Human SMAD5 Protein, His-tagged	E.coli	His		Inquiry
Human	SMAD5-303H	Recombinant Human SMAD5 Protein, His-tagged	E.coli	His	Gly210~Val464	Inquiry
Human	SMAD5-5870H	Recombinant Human SMAD5 Protein (Gly210-Val464), His tagged	E.coli	His	Gly210-Val464	Inquiry
Mouse	SMAD5-479M	Recombinant Mouse Smad5, Gly & Pro tagged	Insect Cell	His		Inquiry
Mouse	Smad5-8679M	Recombinant Mouse Smad5, His-GST tagged	Insect Cell	GST		Inquiry
Mouse	SMAD5-001MCL	Recombinant Mouse SMAD5 cell lysate	Insect Cell	N/A		Inquiry
Mouse	Smad5-3220M	Recombinant Mouse Smad5 protein(Thr2-Ser465)	Insect Cells	N/A	Thr2-Ser465	Inquiry
Mouse	Smad5-3245M	Recombinant Mouse Smad5 protein(Thr2-Ser465), His&GST-tagged	Insect Cells	N-His&GST	Thr2-Ser465	Inquiry
Rhesus Macaque	SMAD5-4333R	Recombinant Rhesus monkey SMAD5 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SMAD5-4149R	Recombinant Rhesus Macaque SMAD5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SMAD5-4149R-B	Recombinant Rhesus Macaque SMAD5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SMAD5-8946Z	Recombinant Zebrafish SMAD5	Mammalian Cell	His		Inquiry
Chicken	SMAD5-2174C	Recombinant Chicken SMAD5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
SMAD5 Related Signal Pathway

SMAD5 involved in several pathways and played different roles in them. We selected most pathways SMAD5 participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TGF-beta signaling pathway	MAPK3;TGFBR1;BMP7B;NOG2;RPS6KB2;SMAD1;PITX2;SMAD5;GDF6A
Signaling pathways regulating pluripotency of stem cells	HNF1A;ID3;WNT2B;RAF1;BMP2;JARID2;ACVR1C;WNT4;ISL1

SMAD5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD5 itself. We selected most functions SMAD5 had, and list some proteins which have the same functions with SMAD5. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	POLR2K;ZNF69;RARAB;BHLHA15;MYCL1;HMGA2;GFI1B;ZHX3;ELF2A
RNA polymerase II core promoter sequence-specific DNA binding	HNF4A;NFIL3;RREB1;SP3;TCF7L2;HOXB3;RBPJ;TP53;NSD1
metal ion binding	OAS1;CAR6;BCL6;ZXDC;RSAD2;LIAS;SP7;ITGB1;CSRP1A
protein binding	SLC6A20B;ATF5;APOA2;SKAP2;RUVBL2;DRD1;FAM195A;PLIN1;CHDH
transcription factor activity, sequence-specific DNA binding	RXRBA;NR5A5;SNAPC4;FOXD1;RORAA;E2F8;FOXO3A;ZNF711;CRX
ubiquitin protein ligase binding	ACTG1;CUL5;RBX1;JKAMP;SPG20;TMBIM6;RNF31;PRKACA;CASP10

SMAD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD5.

Gene Family

Research Area

TGF-beta Family Modulator

Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).

Yao, QP; Zhang, P; et al. The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 49:98-104(2014).