SMAD5

  • Official Full Name

    SMAD family member 5

  • Overview

    The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
  • Synonyms

    SMAD5; SMAD family member 5; DWFC; JV5-1; MADH5; mothers against decapentaplegic homolog 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; MAD, mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMAD5-31194TH Recombinant Human SMAD5 E.coli N/A
Human SMAD5-2800H Recombinant Human SMAD5, GST-tagged E.coli GST
Human SMAD5-1493H Recombinant Human SMAD Family Member 5, GST-tagged E.coli GST
Human SMAD5-162H Recombinant Human SMAD5 Protein, His-tagged E.coli His
Human SMAD5-303H Recombinant Human SMAD5 Protein, His-tagged E.coli His
Human SMAD5-5870H Recombinant Human SMAD5 Protein (Gly210-Val464), His tagged E.coli His
Mouse SMAD5-479M Recombinant Mouse Smad5, Gly & Pro tagged Insect Cell His
Mouse Smad5-8679M Recombinant Mouse Smad5, His-GST tagged Insect Cell GST
Mouse SMAD5-001MCL Recombinant Mouse SMAD5 cell lysate Insect Cell N/A
Mouse Smad5-3220M Recombinant Mouse Smad5 protein(Thr2-Ser465) Insect Cells N/A
Mouse Smad5-3245M Recombinant Mouse Smad5 protein(Thr2-Ser465), His&GST-tagged Insect Cells N-His&GST
Rhesus Macaque SMAD5-4333R Recombinant Rhesus monkey SMAD5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SMAD5-4149R Recombinant Rhesus Macaque SMAD5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SMAD5-4149R-B Recombinant Rhesus Macaque SMAD5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SMAD5-8946Z Recombinant Zebrafish SMAD5 Mammalian Cell His
Chicken SMAD5-2174C Recombinant Chicken SMAD5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMAD5 Related Articles
  • SMAD5 Related Gene Family
  • SMAD5 Related Research Area
  • SMAD5 Related Signal Pathway

SMAD5 involved in several pathways and played different roles in them. We selected most pathways SMAD5 participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayGDF5;ACVR1BA;CUL1;ID2;BMP2;TFDP1;NODAL;BMPR1AA;SMAD5
Signaling pathways regulating pluripotency of stem cellsWNT7A;BMPR1A;FZD2;ID1;LIFR;AKT1;PIK3R2;ESX1;INHBB

SMAD5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD5 itself. We selected most functions SMAD5 had, and list some proteins which have the same functions with SMAD5. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZMYM4;SEBOX;FOXN2B;SMARCA5;RNF6;ARID3B;HIST1H2BI;ZFPM2;ZNF573
RNA polymerase II core promoter sequence-specific DNA bindingH2AFY;NSD1;GATA3;TFAP2B;GATA1;ZFPM1;HNF4A;NFIL3;NR4A2
metal ion bindingGPHN;GALNS;ADCY9;TPH1B;ZNF428;ZFP488;CLCNKA;PPTC7;SOBPA
protein bindingCCR5;IPO5;DSP;DEPDC6;SERPINF2;KRT81;KIF13B;FGFR2;APPL1
transcription factor activity, sequence-specific DNA bindingSPI1A;FOXS1;FOXF2;PITX2;ZKSCAN14;ZNF302;IRF1B;HMGB1;FOXO4
ubiquitin protein ligase bindingLTBR;RALB;UBE2J1;TRAF4;SCAMP3;MAGEC2;SMAD2;UCHL1;SPOP

SMAD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD5.

Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
Yao, QP; Zhang, P; et al. The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 49:98-104(2014).
TGF
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