smpd1
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  • Official Full Name
  • sphingomyelin phosphodiesterase 1, acid lysosomal
  • Background
  • Sphingomyelinases (SMases) catalyze the hydrolysis of sphingomyelin to produce ceramide and phosphocholine. Ceramide is an important bioactive lipid triggering signal transduction involved in cell proliferation, apoptosis and differentiation. A number of
  • Synonyms
  • SMPD1; sphingomyelin phosphodiesterase 1, acid lysosomal; sphingomyelin phosphodiesterase; acid sphingomyelinase; ASM; NPD; ASMASE
Cat.#:SMPD1-537HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMPD1 Protein, His-tagged
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Cat.#:SMPD1-2065HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMPD1 Protein, MYC/DDK-tagged
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Cat.#:SMPD1-26292THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SMPD1
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Cat.#:SMPD1-610HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human SMPD1, His-tagged
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Cat.#:SMPD1-655HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMPD1, His tagged
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Cat.#:SMPD1-656HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMPD1, His tagged
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Cat.#:SMPD1-6851HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMPD1 protein, His & T7-tagged
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Cat.#:Smpd1-2552MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Smpd1, His tagged
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Cat.#:SMPD1-702HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMPD1 cell lysate
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Cat.#:SMPD1-716HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SMPD1 cell lysate
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Cat.#:SMPD1-486MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SMPD1 cell lysate
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Involved Pathway

SMPD1 involved in several pathways and played different roles in them. We selected most pathways SMPD1 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid metabolism
SGMS1; NEU3.3; ARSJ; FA2H; CERS5; PPAP2C; GLTPA; COL4A3BP; CERK; B4GALT6
Metabolic pathways
PPCDC; PNLIPRP3; ACSM2; NDUFB10; ST6GALNAC1; UGT1A3; HAL; LIPT2; B3GALT4; CYP2U1
Sphingolipid signaling pathway
PRKCE; TRP53; PPP2R2A; DEGS2; TRADD; LASS4; GNAQ; MAP2K2; PIK3R1; PPP2R5A
Lysosome
ACP2; LIPA; ATP6V0C; PSAP; NAPSA; HGSNAT; LAPTM4A; GM2A; MANBA; CLN3

Protein Function

SMPD1 has several biochemical functions, for example, hydrolase activity, acting on glycosyl bonds, protein binding, sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMPD1 itself. We selected most functions SMPD1 had, and list some proteins which have the same functions with SMPD1. You can find most of the proteins on our site.
Function
Related Protein
Function hydrolase activity, acting on glycosyl bonds
Related Protein MAN1A; SMPDL3A; MACROD1; NEIL1; Amy1; LCTLB; UNGA; MACROD2; HPSE2; SPACA5
Function protein binding
Related Protein ZNF792; EMP3; INPP5K; PDCD1; ATG4B; C10orf46; RASSF4; INHBB; LOC729991; KHDRBS1
Function sphingomyelin phosphodiesterase activity
Related Protein SMPD2A; SMPD2; SMPD4; SMPD3; SMPD5; SMPD1; ENPP7; SMPDL3B; SMPDL3A

Interacting Protein

SMPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMPD1.
CASP7; CASP8; ANXA4; ANXA7; NR1H2; DUSP23; TNFRSF1A