SP1
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Official Full Name
Sp1 transcription factor
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Overview
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] -
Synonyms
SP1; Sp1 transcription factor; transcription factor Sp1; specificity protein 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HeLa
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- C
- His
- GST
- HA|Flag
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SP1 Related Articles
SP1 involved in several pathways and played different roles in them. We selected most pathways SP1 participated on our site, such as TGF-beta signaling pathway, Estrogen signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | SMAD3;TFDP1;ACVR2AA;BMPR2A;TGFB1;BMPR1B;RHOAA;BMP8A;MAPK3 |
| Estrogen signaling pathway | MMP2;ESR2;KRAS;PIK3R1;HSPA1B;CREB3L1;AKT2;ESR1;NRAS |
| Huntingtons disease | HIP1;POLR2H;DNAI1;UQCR11;SLC25A31;SLC25A6;SP1;SOD2;POLR2G |
| Transcriptional misregulation in cancer | FLI1;MLLT1;IL1R2;TGFBR2;CEBPE;PAX5;SUPT3H;SP1;RXRB |
| Choline metabolism in cancer | MAPK3;MAP2K2;PIK3CD;EGF;PDGFC;GRB2;SLC22A5;PIP5K1C;CHKA |
SP1 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP1 itself. We selected most functions SP1 had, and list some proteins which have the same functions with SP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SIX4;TADA2B;FOXJ1;CXXC1A;NKX6.1;ZEB2;PREB;NR1H3;DBX1A |
| HMG box domain binding | POU3F3;OLIG2;JUN;MEOX1;HOXA3;HOXC4;UTF1;SP1;PRRX1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MYC;OTX2;MED8;ZKSCAN3;ONECUT2;ZNF100;SPI1;RELA;ZIC1 |
| RNA polymerase II core promoter sequence-specific DNA binding | EP300;SFPI1;NSD1;NLRC5;H3F3A;YAP1;TBR1;HNF4A;H2AFY |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZBTB12.2;RXRB;TFAP2D;TBX5;LMO2;ZNF711;ETV6;ZNF561;ARID3A |
| RNA polymerase II repressing transcription factor binding | TCERG1;SP1;DMAP1;BBS1;BBS4;HDAC1;RBBP8;TTC8;HDAC2 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXS1;SOX5;BETA3;AHR2;FOXQ1;ZSCAN5A;GATA6;ZNF215;SIM1A |
| bHLH transcription factor binding | BHLHE40;SIRT1;PSMD9;EP300;FOXH1;IKZF4;TCF3;HAND1;MAP3K10 |
| core promoter sequence-specific DNA binding | TP53;REST;CHD2;PDX1;PPARG;KLF10;SOX9;PRMT5;C1orf51 |
| double-stranded DNA binding | HMGB2;SP1;SMAD2;ERCC5;MTERF;PNKP;TRP53;NTHL1;XRCC3 |
| enhancer binding | ARNT;RAI1;SMAD3;LEF1;SOX9;TCF3;ELL3;SMAD2;TCF12 |
| histone acetyltransferase binding | NR4A3;KAT2B;TP53;SP1;FOXP3;ETS1;TRIM68;EPAS1;MEF2A |
| histone deacetylase binding | SOD3;KAT2B;CBX5;TRAF6;MECP2;CAMTA2;HOXA10;HDAC1;NR2E1 |
| metal ion binding | PRDM1;EXTL2;ZNF521;NEK1;BCL11B;SMYD1B;KAT6A;NT5M;Trf |
| protein C-terminus binding | TAF13;ZBTB16;SNX17;CDC20;CORO1A;TCF4;AGO2;NCF2;PRDX3 |
| protein binding | TACC1;CPSF4;CARF;TRIM6;DSCAM;CRK;KDM4A;PBX2;TIRAP |
| protein homodimerization activity | CORO1A;TNNC1;IRAK2;ACTN1;TG;MAP3K13;CHMP1A;IDE;IL17F |
| sequence-specific DNA binding | NFIL3-5;CREMB;HOXA1A;ZSCAN16;RARGA;NR4A2A;RX3;LEF1;MNX1 |
| transcription factor activity, sequence-specific DNA binding | SOX32;MTA2;NFYA;THRAA;MYCA;SOX9;E2F6;SOLH;TAF5L |
| transcription factor binding | HMGA1-RS1;MSX2;CDK9;CXXC5;PSMC5;HES6;MED6;FOXA1;IFI203 |
| transcription regulatory region DNA binding | GABPA;RCOR1;BCL11B;KLF11;ZFP821;SMAD3;GATA3;MTERFD3;PHB |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | OTX2;ATOH1;GLI3;ONECUTL;BARHL2;MAFB;RUNX2;GATA2;MYB |
SP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP1.
POU2F1; STAT3; HCFC1; SREBF2; tf65_human_gc-box3_dna-probe
- Q&As
- Reviews
Q&As (5)
Ask a questionSP1 plays a role in immune response by regulating the expression of genes involved in inflammation and immune cell function. Its modulation can influence the immune system's response to various stimuli.
Yes, SP1 is implicated in cardiovascular diseases by regulating genes involved in vascular smooth muscle cell proliferation and migration. Targeting SP1 may offer therapeutic avenues for cardiovascular conditions.
Yes, SP1 has been implicated in neurodegenerative diseases. Its role in regulating genes related to neuronal survival and death makes it a target for exploring therapeutic interventions in conditions like Alzheimer's disease.
Yes, elevated levels of SP1 have been observed in certain cancers. Detection of SP1 expression can potentially serve as a diagnostic marker, aiding in the early identification of cancer.
SP1 regulates the expression of genes involved in angiogenesis, the formation of new blood vessels. Increased SP1 activity is associated with enhanced angiogenesis, which can be critical in wound healing and tumor growth.
Customer Reviews (3)
Write a reviewIn addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the SP1 protein.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.
By relying on the SP1 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.
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