|Official Full Name||toll-like receptor 1|
|Background||The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.|
|Synonyms||TLR1; toll-like receptor 1; TIL; CD281; rsc786; KIAA0012; MGC104956; MGC126311; MGC126312; TIL. LPRS5; DKFZp547I0610; DKFZp564I0682; OTTHUMP00000218158; OTTHUMP00000218173; OTTHUMP00000218175; toll/interleukin-1 receptor-like protein; Similar to Drosophila Toll protein; Toll (Drosophila) homolog; Toll like receptor 1; Toll like receptor 1 Precursor; Toll/Interleukin 1 receptor like|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
tlr1 involved in several pathways and played different roles in them. We selected most pathways tlr1 participated on our site, such as Toll-like receptor signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with tlr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Toll-like receptor signaling pathway||IRAK4; MAPK8A; MAPK11; IFNA8; TLR9; RAC1A; MAPK8B; IFNB1; CCL3; TLR3|
|Tuberculosis||CD209C; IL18; RAB7A; CALML5; FCGR4; LSP1; ITGAM; IFNGR1; ATP6V0A4; CLEC7A|
tlr1 has several biochemical functions, for example, Toll-like receptor 2 binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tlr1 itself. We selected most functions tlr1 had, and list some proteins which have the same functions with tlr1. You can find most of the proteins on our site.
|Toll-like receptor 2 binding||TLR1; TLR6; TIRAP|
|protein binding||UGGT2; ZBTB7C; NPAS2; MTERFD2; RASSF3; ABCD3; CEBPG; KCNG3; USP18; HOXD12|
|protein heterodimerization activity||MID1; SOX14; ARNT2; SNX5; BNIP3; ZHX3; PVRL1; EGFR; UNC13A; TPD52|
|receptor activity||SMAGP; TEK; NLGN4Y; F2RL1.2; LDLR; F2RL1; JMJD6; IGSF1; STRA6; CLEC4E|
|transmembrane signaling receptor activity||FZD3B; Cd79a, Cd79b; FZD9B; TLR4; IL1R1; GP6; CLDN3; IL11RA; EBP; CALCRLA|
tlr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tlr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of tlr1.