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Official Full Name toll-like receptor 1
Background The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
Synonyms TLR1; toll-like receptor 1; TIL; CD281; rsc786; KIAA0012; MGC104956; MGC126311; MGC126312; TIL. LPRS5; DKFZp547I0610; DKFZp564I0682; OTTHUMP00000218158; OTTHUMP00000218173; OTTHUMP00000218175; toll/interleukin-1 receptor-like protein; Similar to Drosophila Toll protein; Toll (Drosophila) homolog; Toll like receptor 1; Toll like receptor 1 Precursor; Toll/Interleukin 1 receptor like
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Yeast
    • Tag :
    • Fc
    • GST
    • hIgG1
    • hIgG4
    • His
    • S
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TLR1-1047HCL Recombinant Human TLR1 293 Cell Lysate HEK293 N/A
    Human TLR1-1815H Recombinant Human TLR1 Protein (25-580 aa), His-tagged Yeast His
    Human TLR1-2069H Recombinant Human TLR1 protein, His & S-tagged E.coli His/S
    Human TLR1-2393H Recombinant Human Toll-like Receptor 1, Fc Chimera HEK293 Fc
    Human TLR1-3257H Recombinant Human TLR1, GST-tagged E.coli GST
    Human TLR1-685H Recombinant Human TLR1, Fc Chimera NS0 Fc
    Human TLR1-686H Recombinant Human TLR1, Fc-tagged NS0 Fc
    Human TLR1-705H Recombinant Human TLR1, Fc-tagged, Biotinylated Human Cell Fc
    Human TLR1-706H Recombinant Human TLR1, Fc-tagged Human Cell Fc
    Mouse Tlr1-2070M Recombinant Mouse Tlr1 protein, His & GST-tagged E.coli His/GST
    Rhesus monkey TLR1-1664R Recombinant Rhesus Monkey TLR1 Protein HEK293 N/A
    Rhesus monkey TLR1-1665R Recombinant Rhesus Monkey TLR1 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey TLR1-1666R Recombinant Rhesus Monkey TLR1 Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque TLR1-4729R Recombinant Rhesus monkey TLR1 Protein, His-tagged Mammalian Cell His
    Zebrafish TLR1-7077Z Recombinant Zebrafish TLR1 Mammalian Cell His

    tlr1 involved in several pathways and played different roles in them. We selected most pathways tlr1 participated on our site, such as Toll-like receptor signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with tlr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toll-like receptor signaling pathway IRAK4; MAPK8A; MAPK11; IFNA8; TLR9; RAC1A; MAPK8B; IFNB1; CCL3; TLR3
    Tuberculosis CD209C; IL18; RAB7A; CALML5; FCGR4; LSP1; ITGAM; IFNGR1; ATP6V0A4; CLEC7A

    tlr1 has several biochemical functions, for example, Toll-like receptor 2 binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tlr1 itself. We selected most functions tlr1 had, and list some proteins which have the same functions with tlr1. You can find most of the proteins on our site.

    Function Related Protein
    Toll-like receptor 2 binding TLR1; TLR6; TIRAP
    protein binding UGGT2; ZBTB7C; NPAS2; MTERFD2; RASSF3; ABCD3; CEBPG; KCNG3; USP18; HOXD12
    protein heterodimerization activity MID1; SOX14; ARNT2; SNX5; BNIP3; ZHX3; PVRL1; EGFR; UNC13A; TPD52
    receptor activity SMAGP; TEK; NLGN4Y; F2RL1.2; LDLR; F2RL1; JMJD6; IGSF1; STRA6; CLEC4E
    transmembrane signaling receptor activity FZD3B; Cd79a, Cd79b; FZD9B; TLR4; IL1R1; GP6; CLDN3; IL11RA; EBP; CALCRLA

    tlr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tlr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of tlr1.


    Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
    Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).

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