tp53
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  • Official Full Name
  • tumor protein p53
  • Background
  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
  • Synonyms
  • TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53;
Cat.#:TP53-1076HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P53
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Cat.#:TP53-15HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53 protein, GST-tagged
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Cat.#:TP53-170HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P53
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Cat.#:TP53-171HTag:Myc/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53 Protein, Myc/DDK-tagged
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Cat.#:TP53-172HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TP53 Protein, DDK-tagged
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Cat.#:TP53-185HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53 protein
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Cat.#:TP53-26HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30262THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53
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Cat.#:TP53-30547THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, GST-tagged
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Cat.#:TP53-30570THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30571THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30572THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-30573THTag:GST
Source (Host):Species:Human
Product nameRecombinant Human TP53, GST-tagged
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Cat.#:TP53-31456THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53
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Cat.#:TP53-3412HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-3436HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-3445HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-58HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-611HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP53, His-tagged
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Cat.#:TP53-75HTag:Flag
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TP53 protein, Flag-tagged
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Cat.#:Tp53-5633RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tp53 protein, His-tagged
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Cat.#:TP53-6230RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TP53 Protein
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Cat.#:TP53-1044CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TP53 Protein, His-tagged
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Cat.#:TP53-1162CTag:
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TP53 Protein
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Cat.#:TP53-4910RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TP53 Protein, His-tagged
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Cat.#:TP53-6816CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TP53
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Cat.#:TP53-8275ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TP53
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Cat.#:TP53-325HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P53, GST-tagged
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Cat.#:TP53-1077HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P53, GST-tagged
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Cat.#:TP53-860HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TP53 293 Cell Lysate
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Involved Pathway

TP53 involved in several pathways and played different roles in them. We selected most pathways TP53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF4; CASP3A; MAPK3; PPP5C; GNG12; RPS6KA3; FGF12; RAF1A; HSPA1L; FGF9
Sphingolipid signaling pathway
PPP2R2B; MAPK8; PPP2R1B; CERS4; MAP2K1; MAPK9; PPP2R5A; RAF1; MAPK1; RELA
Cell cycle
CENPJ; CEP57; ORC6; NDEL1; HDAC1; DMC1; PIANP; CCND2A; RBX1; GADD45A
p signaling pathway
FAS; APAF1; ATM; RFWD2; CDK1; SESN2; SIAH1; THBS1; CCND3; CCNB3
PIK-Akt signaling pathway
CRTC2; F2R; G6PC3; PPP2R1B; CREB3L3; IFNA14; TNN; PTK2; PPP2R1A; GNG13
Apoptosis
Casp3; AKT2L; CASP9; TRADD; BOKA; NFKBIA; XIAP; IRF4A; DYNLL2; BCAP31
Wnt signaling pathway
CAMK2D; NKD2B; RAC3B; WNT7AA; SFRP5; NLK; FZD7; DVL3A; ROCK2; CAMK2B1
Neurotrophin signaling pathway
ZFP110; PIK3CA; KIDINS220; CDC42; GRB2; BCL2; CAMK2A; PSEN2; ARHGDIG; MAP2K2
Thyroid hormone signaling pathway
PLN; PLCD1; ACTG1; PRKACB; PLCB2; BAD; ITGB3; MDM2; RXRG; MTOR
Amyotrophic lateral sclerosis (ALS)
NEFL; TP53; Casp3; PRPH; TNF; DAXX; GRIN2D; CASP1; GRIN2C; SOD1
Huntingtons disease
COX4I2; UQCR11; GRIN1; SLC25A5; POLR2L; SIN3A; COX7A2; GRM5; POLR2D; NDUFS6
Hepatitis C
BRAF; PDPK1; IRF1; TNFRSF1A; OAS3; MAPK8; AKT1; PPP2R1B; CXCL8; CLDN11
Hepatitis B
PIK3CD; IKBKE; PIK3CB; BAD; IFIH1; MAPK10; ATP6AP1; VDAC3; TGFB3; IRF3
Measles
IFNAR1; EIF2AK4; PRKCQ; IFNA17; OAS1B; PIK3R5; FYN; TLR2; TNFRSF10D; STAT3
HTLV-I infection
WNT7A; ANAPC5; CALR; NFATC4; FOS; TP53INP1; BUB1B; WNT2B; H2-AA; ETS1
Herpes simplex infection
POU2F3; HNRPK; HLA-DRB3; IFNA21; IFNA2; BLB1; SRSF2A; SRSF7B; BLA; ARNTL
Epstein-Barr virus infection
SHFM1; POLR2K; AKT2; HSPA1L; PSMD4; PSMC4; POLR3GL; XPO1; CD44; HLA-DRB5
Pathways in cancer
MITF; WNT5B; PPARG; LAMB3; WNT7B; LAMB2; CTNNA3; TRAF5; EP300; LAMB4
Transcriptional misregulation in cancer
BIRC3; RUNX2; HOXA9; H3F3B; CCNT1; IGF1; DOT1L; PTCRA; BCL6; FCGR1A
Viral carcinogenesis
CCNE1; IRF7; ATP6V0D2; HLA-E; NRAS; GTF2H4; PIK3R3; SND1; NFKB2; GTF2B
Proteoglycans in cancer
ERBB4; WNT8A; TWIST1; VEGFA; HOXD10; CBL; TFAP4; PTPN6; PRKACB; SRC
MicroRNAs in cancer
DNMT3B; TRP63; MDM4; NOTCH2; WNT3A; VIM; PTGS2; GRB2; KIF23; STAT3
Colorectal cancer
SMAD3; TGFB1; RAC2; BRAF; PIK3CG; ARAF; APPL1; Casp3; AXIN1; MAPK8
Pancreatic cancer
RALB; MAPK9; TGFB1; RALGDS; RALBP1; PIK3CD; BRAF; RAD51; MAP2K1; ARAF
Endometrial cancer
HRAS; TCF7; PIK3CD; PIK3CG; MAP2K2; PIK3CB; FOXO3; ERBB2; MAPK3; ILK
Glioma
SHC1; NRAS; SHC4; CAMK2G; GRB2; MAPK1; TRP53; PIK3CG; PDGFRA; CAMK2B
Prostate cancer
SMARCD1; RELA; LEF1; NFKB1; MAPK3; EP300; PDPK1; TGFA; TP53; PIK3R5
Thyroid cancer
MAPK1; RXRG; TPM3; TPR; NCOA4; CCND1; TFG; TRP53; NRAS; TCF7L2
Basal cell carcinoma
APC; WNT7B; WNT8B; DVL2; FZD5; WNT2; WNT11; DVL3; WNT10B; TRP53
Melanoma
FGF16; FGF20; MAP2K2; FGF3; MAPK1; FGF22; PDGFD; FGF18; FGF5; AKT1
Bladder cancer
E2F3; CDKN2A; ERBB2; RASSF1; MAP2K1; E2F2; SRC; E2F1; THBS1; CDH1
Chronic myeloid leukemia
AKT1; NRAS; NFKB1; CBL; CTBP2; MAP2K2; SMAD3; IKBKB; BCL2L1; KRAS
Small cell lung cancer
RELA; CASP9; ITGB1; LAMA4; RXRG; NFKBIA; CYCS; RB1; SKP2; BIRC2
Non-small cell lung cancer
RAF1; TP53; MAPK1; MAP2K2; FOXO3; PDPK1; EML4; ERBB2; PLCG2; PRKCA
Central carbon metabolism in cancer
PDHA2; PDHB; NTRK3; PFKP; SIRT3; TRP53; SLC16A3; PDGFRB; SLC2A1; MAP2K1

Protein Function

TP53 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53 itself. We selected most functions TP53 had, and list some proteins which have the same functions with TP53. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein BMX; MCCC1; SBK1; Adcy4; PLK5; ACSS1; DHX35; SMC2; CSK; BSK146
Function DNA binding
Related Protein FOXP1A; CSDE1; HER2; POLR1E; SPATA24; ZNF43; DTD1; ZFAT; PRIM2; NKX1.2LA
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein MAZ; RREB1; STAT6; H2AFY; ZFP335; HOXB3; NR4A2; H3F3A; ZNF335; TFAP2A
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXJ1B; HIF1AL; KLF11; BMPR1A; FOXG1B; MEF2A; AHR2; FOXD2; FOXJ1A; GATA6
Function RNA polymerase II transcription factor binding
Related Protein GATA4; TBX3; GATA5; GATA6; XBP1; GATA2; ZGLP1; GATA1A; GATA1; MTDH
Function chaperone binding
Related Protein DNAJB8; DNAJC10; TBCE; DNAJA3A; DNAJB6; CLU; BAG1; DNAJB4; HSP104; TIMM9
Function chromatin binding
Related Protein SOX15; HCFC1; ZEB1; NEUROG1; KAT2A; TCF7L2; MEIOB; TFAM; NSD1; NOC3L
Function copper ion binding
Related Protein GPC1; SNAI3; SERPINB1A; ATP7B; METTL17; PRND; SLC11A2; CCC2; LOXL4; COX11
Function core promoter sequence-specific DNA binding
Related Protein PROX1; PPARG; H2AFY; CREM; SOHLH1; RORA; ESR2; KLF10; PDX1; SOX4
Function damaged DNA binding
Related Protein PCNA; CREBBP; HMGB1; TDG; XRCC5; DCLRE1C; TP53BP1; PNKP; RAD23A; FEN1
Function double-stranded DNA binding
Related Protein YBX1; TP53; FBXO18; RAD51D; TRP63; MTERF2; HNRPDL; CGGBP1; RAD51B; EGFR
Function enzyme binding
Related Protein KDM1A; SCARB2; PPP1R3D; WWOX; HIST1H2AE; ZFHX3; TOP2B; PHKG2; C2orf56; HINFP
Function histone acetyltransferase binding
Related Protein SIRT2; GLI3; MTF1; CREB1; FOXP3; TRIM68; TAF7L; TRP53; EID1; CEBPB
Function histone deacetylase regulator activity
Related Protein TP53; TRP53; MAPK8; NCOR1
Function identical protein binding
Related Protein RUVBL2; EPS15; ADIPOR2; MPST; LEPR; GSTM3; CEP72; NELL2; RBM10; PKD2
Function p53 binding
Related Protein GATA1; AXIN1; ZNF385C; TRIAP1; NTRK3; KDM1A; EP300; ANKRD1; ZMAT4; DAXX
Function protease binding
Related Protein Casp3; IL1R1; SERPINC1; INS; ANXA2; CD70; ADAMTSL4; SERPINE1; PANX1; ADAM8A
Function protein N-terminus binding
Related Protein CHMP6; HAX1; EIF3E; ERCC6; VWF; TP53; ERCC3; PARP1; ALG2; NTSR1
Function protein binding
Related Protein NRG4; SLN; COPB1; SIGLEC8; FAM21C; RASL10B; CD47; MEMO1; SRSF11; PTI
Function protein heterodimerization activity
Related Protein NPAS4; GCA; ABCG8; ATP4A; H2BFWT; P4HB; NKX2; SYT16; NFE2L2A; SNX5
Function protein kinase binding
Related Protein EMP2; KIF11; CCNK; PAX6; ZC3HC1; MAP3K2; CD3E; ACTA2; FAF1; CDKN2D
Function protein phosphatase 2A binding
Related Protein FOXO1; CPD; STRN4; SPHK1; ARPP19; IGBP1; PPP2R4; PPME1; BCL2; HMGCR
Function protein phosphatase binding
Related Protein PPARG; RPA2; VCP; MET; HSP90B1; STAT6; ANAPC7; STAT3; ROS1; SKAP1
Function protein self-association
Related Protein NKX3; TMEM190; ACHE; ACVR2A; S100A7A; ADAM8; CTSB; CCL5; LDB1; CCDC88C
Function receptor tyrosine kinase binding
Related Protein TP53; NRG3; ZNF259; MYOC; ANGPT4; ANGPT1; NCK1; TOB1; SHC3; ARHGEF16
Function sequence-specific DNA binding
Related Protein VSX1; GRHL1; HOXC3A; THRAA; ESR2B; ATF6B; FOXB1; SIX4B; SLAMF7; HIC1
Function transcription factor activity, sequence-specific DNA binding
Related Protein TFAM; NR5A5; GATAD2AB; POU5F1; ZFP184; DMRT2; FOXD2; IKZF1; ZHX2; ZNF445
Function transcription factor binding
Related Protein JUNBA; APBB1; MYOD1; PDX1; GPX3; PSMC5; AIP; GATA6; TRIM6; RNF222
Function transcription regulatory region DNA binding
Related Protein NFKB1; HNRNPL; SNCA; NFE2L2; SP1; ZNF567; MTERFD3; POU5F1; TFAP4; TFEB
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HNRNPK; HIF1A; ETV6; TLX1; ATF2; FOXJ2; SIX2; ESRRA; ZFP292; SOX11
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein TBX5; SOHLH2; BARX2; FOXO3; EP300; DMRT1; SOHLH1; PAX9; AIRE; MYOD1
Function ubiquitin protein ligase binding
Related Protein UBE2K; TRIOBP; TNFRSF14; HDAC6; TRIM28; EIF4E2; CUL1B; MAP1LC3C; AMBRA1; MC4R
Function zinc ion binding
Related Protein LNX2A; BHMT; YY1; TRAF3; LONRF1L; NR6A1B; TRIM23; NR1H3; ZNF276; DMD

Interacting Protein

TP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53.
MDM2

TP53 Related Articles

Sadahira, Y; Sugihara, T; et al. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. VIRCHOWS ARCHIV 466:343-350(2015).
Fuentes-Raspall, MJ; Caragol, I; et al. Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism. APOPTOSIS 20:371-382(2015).