tp53

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tp53

Official Full Name tumor protein p53
Background This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
Synonyms TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TP53-983H Recombinant Human TP53 Protein, His-tagged E.coli His
    Human TP53-1823H Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TP53-4893H Recombinant Human TP53 (Y220C) Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human TP53-489H Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TP53-6044H Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TP53-1076H Recombinant Human Tumor Protein P53 Sf9 Insect Cell N/A
    Human TP53-1077H Recombinant Human Tumor Protein P53, GST-tagged E.coli GST
    Human TP53-15H Recombinant Human TP53 protein, GST-tagged E.coli GST
    Human TP53-170H Recombinant Human Tumor Protein P53 E.coli N/A
    Human TP53-171H Recombinant Human TP53 Protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human TP53-172H Recombinant Human TP53 Protein, DDK-tagged Insect Cell DDK
    Human TP53-185H Recombinant Human TP53 protein E.coli N/A
    Human TP53-26H Recombinant Human TP53, His-tagged E.coli His
    Human TP53-30262TH Recombinant Human TP53 E.coli N/A
    Human TP53-30547TH Recombinant Human TP53, GST-tagged E.coli GST
    Human TP53-30570TH Recombinant Human TP53, His-tagged His
    Human TP53-30571TH Recombinant Human TP53, His-tagged His
    Human TP53-30572TH Recombinant Human TP53, His-tagged His
    Human TP53-30573TH Recombinant Human TP53, GST-tagged GST
    Human TP53-31456TH Recombinant Human TP53 E.coli N/A
    Human TP53-325H Recombinant Human Tumor Protein P53, GST-tagged Sf9 Insect Cell GST
    Human TP53-3412H Recombinant Human TP53, His-tagged E.coli His
    Human TP53-3436H Recombinant Human TP53, His-tagged HEK293 His
    Human TP53-3445H Recombinant Human TP53, His-tagged Insect Cell His
    Human TP53-58H Recombinant Human TP53, His-tagged E.coli His
    Human TP53-611H Recombinant Human TP53, His-tagged E.coli His
    Human TP53-75H Recombinant Human TP53 protein, Flag-tagged E.coli Flag
    Human TP53-860HCL Recombinant Human TP53 293 Cell Lysate HEK293 N/A
    Rat Tp53-5633R Recombinant Rat Tp53 protein, His-tagged E.coli His
    Rat TP53-6230R Recombinant Rat TP53 Protein Mammalian Cell His
    Cynomolgus Monkey TP53-1044C Recombinant Cynomolgus TP53 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey TP53-1162C Recombinant Cynomolgus TP53 Protein E.coli N/A
    Rhesus Macaque TP53-4910R Recombinant Rhesus monkey TP53 Protein, His-tagged Mammalian Cell His
    Chicken TP53-6816C Recombinant Chicken TP53 Mammalian Cell His
    Zebrafish TP53-8275Z Recombinant Zebrafish TP53 Mammalian Cell His

    tp53 involved in several pathways and played different roles in them. We selected most pathways tp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with tp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway Fgf15; MAPK8IP2; TMEM37; PPM1AB; MAP3K12; NTF4; RPS6KA6; MAPK12B; CACNG6; HSPA1B
    Sphingolipid signaling pathway MAP3K5; PPP2CA; S1PR5; PPP2R2C; RAC1; PRKCE; SGPL1; PPP2R2B; TRADD; AKT1
    Cell cycle TBC1D8; CDK4; NSL1; PCM1; CP110; DCTN1; SPC24; CCND1; UIMC1; NDEL1
    p signaling pathway STEAP3; BBC3; PTENA; SIAH1A; SHISA5; ZMAT3; THBS1; APAF1; PIDD1; COP1
    PIK-Akt signaling pathway Itga10&Itgb1; ANGPT1; MLST8; IL6R; YWHAZ; GSK3B; GH2; GH1; GNG5; LAMB4
    Apoptosis CAPN1A; IRF1B; PIK3R2; PRKAR1B; TNFRSF10C; DIABLO; CTNNB2; STK24A; NFKB1; HIST1H1D
    Wnt signaling pathway ROCK2; CAMK2D2; MMP7; WNT8A; TBL1Y; RHOAA; PPP3CA; TCF7L2; CER1; FBXW11
    Neurotrophin signaling pathway RPS6KA2; FASLG; ABL1; PDPK1; IRAK1; PTPN11; Fasl; IRS1; MAPK13; NTF4
    Thyroid hormone signaling pathway HRAS; ACTG1; NCOR1; PLCD4; MED17; ATP1A3; TSC2; MED24; WNT4; ATP1A1
    Amyotrophic lateral sclerosis (ALS) TNFRSF1B; MAPK11; GRIA2; DAXX; MAPK13; CCS; GRIN2C; ALS2; NEFH; PPP3CC
    Huntingtons disease POLR2E; POLR2C; UQCRH; NDUFB5; RCOR1; SDHC; DNAH11; HAP1; HDAC2; NDUFB11
    Hepatitis C IFNA17; PPP2R1B; CLDN10; EIF2AK1; SOS1; TRADD; CLDN15; RELA; OCLN; MAPK1
    Hepatitis B STAT1; CASP8; IL6; DDB2; AKT1; TNF; PIK3R1; CREB3L3; CYCS; IFNA5
    Measles GSK3B; STAT5B; CD3D; IFNA10; EIF2AK3; PIK3CA; MAP3K7; TNFAIP3; EIF2AK4; DDX58
    HTLV-I infection IL15RA; TRP53INP1; FZD3; HLA-DRB3; H2-AA; TBP; WNT1; IL2RG; DVL2; HLA-A
    Herpes simplex infection HLA-DPB1; CD74A; NFKBIAA; TRAF6; IFNA6; TLR9; ABCB3L1; SRSF7; IFNA21; IFNPHI1
    Epstein-Barr virus infection HSPA8; PSMD6; IRAK1; PIK3R3; RAN; ICAM1; POLR3G; HLA-DQB1; HLA-DQA1; MAPK11
    Pathways in cancer WNT8A; PIK3R2; WNT9B; GNG12; PLD1; TRAF6; IL-8; PIK3CD; LAMB4; FGF14
    Transcriptional misregulation in cancer CDK14; CCNT1; TGFBR2; RUNX1T1; ATF1; HOXA11; Aff1; GOLPH3L; Bcl2a1b; SSX2
    Viral carcinogenesis PIK3R2; RELA; HDAC7A; GTF2A1L; HRAS; ACTN4; DDX3X; IKBKG; SRC; HIST3H2BB-PS
    Proteoglycans in cancer WNT4; PLAU; VTN; ITGB1; PIK3CA; PDPK1; TIMP3; HSPG2; FLNC; TGFB2
    MicroRNAs in cancer PRKCG; MCL1; CCNE1; RASSF1; TRP53; HRAS; TNR; GLS; CDC25A; BRCA1
    Colorectal cancer GSK3B; RHOA; ARAF; TRP53; AKT2; APC2; SMAD3; PIK3CG; TGFB2; AKT1
    Pancreatic cancer MAPK10; TGFB1; BCL2L1; ARAF; PIK3R5; CDC42; SMAD4; RELA; TGFB2; RB1
    Endometrial cancer MAPK3; FOXO3; TP53; TRP53; ERBB2; MAPK1; APC2; MLH1; CASP9; PIK3CD
    Glioma PDGFRB; CALM3; PDGFRA; PIK3R1; PDGFA; TGFA; PIK3CB; PIK3R3; MDM2; PIK3R5
    Prostate cancer MAP4K1; FGFR1; MAPK1; CREB3L2; PDGFRA; Pdgfa&Pdgfb; RELA; FOXA1; BAD; SMARCA4
    Thyroid cancer KRAS; PAX8; RXRG; MAP2K2; NCOA4; LEF1; TCF7; MAPK1; TCF7L2; RXRA
    Basal cell carcinoma FZD8; SETD6; TCF7L2; AXIN2; SMO; FZD1; Shh; FZD7; FZD3; GSK3B
    Melanoma HGF; PIK3R2; FGF12; PDGFRB; PIK3CG; PIK3R5; FGFR1; FGF4; MITF; MAP2K2
    Bladder cancer MYC; RASSF1; ARAF; MMP9; DAPK3; RAF1; MMP1; MAP2K1; FGFR3; MAPK3
    Chronic myeloid leukemia RELA; CRKL; PTPN11; PIK3CA; RAF1; CRK; RB1; MAPK1; MAP2K1; AKT1
    Small cell lung cancer TRP53; PIK3R3; AKT2; PIK3R5; LAMA1; ITGA2; RXRA; PIK3R1; TRAF5; AKT1
    Non-small cell lung cancer PIK3R2; AKT1; PIK3CA; PRKCA; RXRB; ARAF; PIK3R5; MAPK1; AKT2; PIK3R3
    Central carbon metabolism in cancer ERBB2; KIT; SIRT6; TP53; PIK3CD; PDGFRB; HK1; PGAM1; FLT3; HK3

    tp53 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tp53 itself. We selected most functions tp53 had, and list some proteins which have the same functions with tp53. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ADCY8; NEK2; CAMKK1; CAMK2A; MAP2K2A; EHD1; PTK7; RET; SKIV2L2; GLULA
    DNA binding IRX7; VEPH1; C14orf43; ZFP382; HIST1H4F; MCMDC2; MSXA; HOXC13; AGFG1; ARID3C
    RNA polymerase II core promoter sequence-specific DNA binding NFIL3; TFAP2A; IRF7; TFAP2B; TP53; GBX2; YAP1; SFPI1; H3F3A; GATA1
    RNA polymerase II transcription factor activity, sequence-specific DNA binding JUND; HIF1AB; FOXD1L; FOXB1A; NPAS4; SP2; SOX21; FOXD5; FOXP1; FOXO4
    RNA polymerase II transcription factor binding DHX9; TRPS1; Ar; SPI1; TAL1; ANKRD1; SMAD4; GATA3; GATA5; GATA2B
    chaperone binding BAG5; TSACC; AHSA1; HSPE1; GET4; PIH1D3; SOD1; DNAJB4; BAG3; CXorf41
    chromatin binding POU1F1; ZMYND11; FANCM; GATA1A; RAG2; ASH1L; CUX1; FEZF2; RELA; SKI
    copper ion binding S100A13; ABP1; P2RX2; F5; IL1A; LOX; AOC1; SNCA; PRND; TYRP1B
    core promoter sequence-specific DNA binding NR1D1; ZFP750; TRP53; CREM; CHD2; SOX1; H2AFY; PDX1; GATA3; MLL1
    damaged DNA binding NEIL3; CREBBP; RPS3; ERCC3; TDG; NEIL1; APTX; PNKP; RAD23AA; RPA3
    double-stranded DNA binding XRCC5; MTERF; NEIL3; TDP1; USF1; HNRNPDL; NTHL1; HMGB3; TRP63; TP63
    enzyme binding MAPK14; TSPAN17; PHB; THRB; SCNM1; YWHAH; CYP3A4; AXIN2; HDAC2; RFC5
    histone acetyltransferase binding NR4A3; SIRT2; CITED2; CREB1; TRIP4; TRIM68; HIF1A; EID1; TAF7L; TAF7
    histone deacetylase regulator activity NCOR1; TRP53; MAPK8; TP53
    identical protein binding RBM10; HCFC1; MLL1; ACTN2; DAPK2; PRKAB2; DCTPP1; BIN1; HNRNPC; CEP72
    p53 binding GSK3B; TP53; USP10; ANKRD1; TP53RK; AAAS; BANP; DUSP26; SETD7; SETD8
    protease binding RFFL; SERPINB4; PYCARD; BRCA2; UBC; INS; TIMP1; RYR1; TIMP3; ITGB1
    protein N-terminus binding ALG2; BIRC2; SCFD1; PEX5; NFE2; HDAC1; GTF2H3; KCNB1; ARF6; ALOX5AP
    protein binding EMP3; AUP1; PJA1; PPP1R7; DPF2; SOCS1; SLC25A18; AGL; CDC45; PLCB1
    protein heterodimerization activity CEBPE; DRD1; NPM1; NKX2; PDSS1; SYT14; PPP3CA; ATF6; HIST2H2AA4; VAPB
    protein kinase binding TBC1D14; VRK1; LIMS1; AGAP2; GOLGA2; PRC1; KIF14; CCNK; TRAF4; USF1
    protein phosphatase 2A binding TRP53; TP53; ENSAA; EIF4EBP1; MASTL; RPS6KB1; STRN; AKT1; SMG5; GRIN3A
    protein phosphatase binding SKAP1; TRP53; MET; JAK3; PIK3R2; AP3B1; EGFR; VCP; ROS1; MAP3K5
    protein self-association L1CAM; RYR2; LDB1; RSAD2; ABCD3; DVL2; SLC9A3R1; S100A7A; TTN; MDH2
    receptor tyrosine kinase binding TRP53; SQSTM1; PTPN11; ANGPT1; TP53; Flt3l; LRP4; MYOC; NRG1; DNAJA3
    sequence-specific DNA binding BARHL1A; NKX2.2A; NLRP3; NR1H4; BSX; POU3F3A; ESRRGA; THRA; FOXL2; ALX4B
    transcription factor activity, sequence-specific DNA binding FOXI1; FOXN3; BATF; GM239; HIRA; TBX1; ZGPAT; TEAD3B; PBX3B; RUNX2
    transcription factor binding HEY2; RBFOX2; DIP2C; INSIG2; RBL1; DAXX; HDAC9; TFDP1A; THRA; E2F1
    transcription regulatory region DNA binding TAF7; THRA; TAF2; RBBP5; SP1; HINFP; TCF7L1B; TP53; TFE3; SMAD7
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding LEF1; PAX8; SMAD1; ESRRA; ZFAT; MITFB; MZF1; SPI1; MEF2B; TFE3A
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GATA1; ATF1; CSRNP2; GATA3; ATF3; GATA2A; CREB3L4; CTCF; PKNOX1; GRHL3
    ubiquitin protein ligase binding ARIH1; ERBB2; DIO2; FZD6; CXCR4; UBE2N; UBE2C; TUBB; RNF34; UBE2G1A
    zinc ion binding RBM4.1; BRF1; MKRN4; TET1; TADA2A; CPN1; NR5A5; MUL1A; RORB; LASP1

    tp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of tp53.

    MDM2

    Sadahira, Y; Sugihara, T; et al. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. VIRCHOWS ARCHIV 466:343-350(2015).
    Fuentes-Raspall, MJ; Caragol, I; et al. Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism. APOPTOSIS 20:371-382(2015).

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