TP53

  • Official Full Name

    tumor protein p53

  • Overview

    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
  • Synonyms

    TP53; tumor protein p53; P53; BCC7; LFS1; TRP53; cellular tumor antigen p53; antigen NY-CO-13; tumor protein 53; phosphoprotein p53; p53 tumor suppressor; mutant tumor protein 53; transformation-related protein 53;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Yeast
  • C
  • His
  • Avi
  • cMyc,GST
  • DDK
  • Flag
  • GST
  • His (Fc)
  • SUMO
  • Myc
  • Myc|DDK
  • N/A
  • N
  • MBP
  • Strep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TP53-170H Active Recombinant Human Tumor Protein P53 E.coli N/A
Human TP53-3436H Active Recombinant Human TP53, His-tagged HEK293 His
Human TP53-3412H Active Recombinant Human TP53, His-tagged E.coli His
Human TP53-611H Active Recombinant Human TP53, His-tagged E.coli His
Human TP53-1076H Active Recombinant Human Tumor Protein P53 Sf9 Insect Cell N/A
Human TP53-3445H Active Recombinant Human TP53, His-tagged Insect Cell His
Human TP53-1077H Active Recombinant Human Tumor Protein P53, GST-tagged E.coli GST
Human TP53-15H Recombinant Human TP53 protein, GST-tagged E.coli GST
Human TP53-185H Recombinant Human TP53 protein E.coli N/A
Human TP53-58H Recombinant Human TP53, His-tagged E.coli His
Human TP53-30574TH Recombinant Human TP53 protein, GST-tagged E.coli GST
Human TP53-325H Recombinant Human Tumor Protein P53, GST-tagged Sf9 Insect Cell GST
Human TP53-30262TH Recombinant Human TP53 E.coli N/A
Human TP53-30572TH Recombinant Human TP53, His-tagged His
Human TP53-30570TH Recombinant Human TP53, His-tagged His
Human TP53-75H Recombinant Human TP53 protein, Flag-tagged E.coli Flag 409aa
Human TP53-31456TH Recombinant Human TP53 E.coli N/A
Human TP53-172H Recombinant Human TP53 Protein, DDK-tagged Insect Cell DDK
Human TP53-30547TH Recombinant Human TP53, GST-tagged E.coli GST
Human TP53-30573TH Recombinant Human TP53, GST-tagged GST
Human TP53-171H Recombinant Human TP53 Protein, Myc/DDK-tagged HEK293 Myc/DDK
Human TP53-30571TH Recombinant Human TP53, His-tagged His
Human TP53-26H Recombinant Human TP53, His-tagged E.coli His
Human TP53-860HCL Recombinant Human TP53 293 Cell Lysate HEK293 N/A
Human TP53-1823H Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TP53-983H Recombinant Human TP53 Protein, His-tagged E.coli His
Human TP53-4893H Recombinant Human TP53 (Y220C) Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human TP53-30574H Recombinant Human TP53 Protein, GST-tagged E.coli GST
Human TP53-3608H Recombinant Human TP53 protein, His-SUMO-tagged E.coli His-SUMO 1-393aa
Human TP53-489H Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TP53-06HFL Active Recombinant Full Length Human TP53 Protein, C-Flag-tagged Mammalian cells Flag
Human TP53-2771H Recombinant Human TP53 Protein, His-tagged E.coli N-His Gly108-Lys370
Human TP53-010H Recombinant Human TP53 protein, GST-tagged E.coli GST
Human TP53-6044H Recombinant Human TP53 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TP53-2235H Recombinant Human TP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TP53-2772H Recombinant Human TP53 Protein, His-tagged E.coli N-His Met1-Asp393
Human TP53-2235H-B Recombinant Human TP53 Protein Pre-coupled Magnetic Beads HEK293
Human TP53-6491H Recombinant Human TP53 Protein (Met1-Asp393), C-His tagged Mammalian cells C-His Met1-Asp393
Human TP53-18H Active Recombinant Human TP53 R175H (HLA-A*02:01) Tetramer Protein, C-His/Avi tagged HEK293 C-His/Avi Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M)and HMTEVVRHC peptide
Human TP53-2773H Recombinant Human TP53 Protein, His-tagged E.coli N-His Met133-Asp393
Human TP53-6492H Recombinant Human TP53 Protein (Met1-Asp393, R175H), C-His tagged Mammalian cells C-His Met1-Asp393, R175H
Human TP53-6493H Recombinant Human TP53 Protein (Met1-Asp393), N-Strep tagged E.coli N-Strep Met1-Asp393
Human TP53-2548H Recombinant Human TP53 protein(101-310 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 101-310 aa
Human TP53-5537H Recombinant Human TP53 protein, His-tagged Yeast His 1-393aa
Human TP53-4922H Recombinant Human TP53 protein(1-393aa(R273H)), His-tagged Insect Cells C-His 1-393aa(R273H)
Human TP53-123HFL Active Recombinant Full Length Human TP53 Protein, N-cMyc,GST-tagged E.coli cMyc,GST Full Length
Human TP53-4837H Recombinant Human TP53 protein(1-393aa(Y220C)), His-tagged Insect Cells C-His 1-393aa(Y220C)
Human TP53-6494H Recombinant Human TP53 Protein (Full Length), N-His tagged E.coli N-His Full Length
Human TP53-2547H Recombinant Human TP53 protein(301-390 aa), C-His-tagged E.coli C-His 301-390 aa
Human TP53-6495H Recombinant Human TP53 Protein (full-length), N-Strep tagged E.coli N-Strep full-length
Human TP53-4827H Recombinant Human TP53 protein(1-393aa(R175H)), His-tagged Insect Cells C-His 1-393aa(R175H)
Human TP53-6496H Recombinant Human TP53 Protein (Asp7-Asp393), N-His tagged E.coli N-His Asp7-Asp393
Human TP53-5676H Recombinant Human TP53 protein, His-tagged Insect cells N-His 1-393aa
Mouse Tp53-3609M Recombinant Mouse Tp53 protein, His-SUMO-tagged E.coli His-SUMO 1-387aa
Rat Tp53-5633R Recombinant Rat Tp53 protein, His-tagged E.coli His Pro90~Ala354
Rat TP53-6230R Recombinant Rat TP53 Protein Mammalian Cell His
Rat TP53-5887R Recombinant Rat TP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tp53-5297R Recombinant Rat Tp53 protein, His-tagged E.coli His 1-391aa
Rat TP53-5887R-B Recombinant Rat TP53 Protein Pre-coupled Magnetic Beads HEK293
Monkey TP53-1162CAF488 Active Recombinant Cynomolgus TP53 Protein, Alexa Fluor 488 conjugated E.coli 393
Monkey TP53-1162CAF555 Active Recombinant Cynomolgus TP53 Protein, Alexa Fluor 555 conjugated E.coli 393
Monkey TP53-1162CAF647 Active Recombinant Cynomolgus TP53 Protein, Alexa Fluor 647 conjugated E.coli 393
Monkey TP53-1162CF Active Recombinant Cynomolgus TP53 Protein, FITC conjugated E.coli 393
Cynomolgus TP53-1162C Active Recombinant Cynomolgus TP53 Protein E.coli N/A Met 1-Asp 393
Cynomolgus Monkey TP53-1044C Recombinant Cynomolgus TP53 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TP53-787C-B Recombinant Cynomolgus Monkey TP53 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TP53-787C Recombinant Cynomolgus Monkey TP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TP53-4910R Recombinant Rhesus monkey TP53 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TP53-4724R Recombinant Rhesus Macaque TP53 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TP53-4724R-B Recombinant Rhesus Macaque TP53 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TP53-8275Z Recombinant Zebrafish TP53 Mammalian Cell His
Chicken TP53-6816C Recombinant Chicken TP53 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TP53 Related Signal Pathway

TP53 involved in several pathways and played different roles in them. We selected most pathways TP53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayHRASB;RAF1;PLA2G4F;MKNK1;TAOK2;PPP3CC;RAC1A;FGF19;MKNK2
Sphingolipid signaling pathwaySPTLC1;PLCB2;NSMAF;PPP2CB;BDKRB2;KRAS;ASAH2;SGPP1;MAPK9
Cell cycleCDC14AB;SMAD2;CDKN1BB;TUBG2;ENSAA;CDC14A;CDC23;ODF2;CDK4
p signaling pathwayPERP;TNFRSF10B;CCNE1;ATM;RPRMA;PTENA;ZMAT3;TP73;RCHY1
PIK-Akt signaling pathwayPDGFA;TCL1B1;KIT;GNG11;Pdgfa&Pdgfb;PIK3R5;PTEN;IL4R;IKBKG
ApoptosisCAPN2B;IL3;HIST1H1E;STK24A;BADB;CAPN2A;PIK3R3B;BMX;PTBP3
Wnt signaling pathwayCAMK2G1;AXIN2;SKP1;FZD3A;FRAT2;CAMK2D;WNT11B;CUL1A;WNT16
Neurotrophin signaling pathwayRAC1;BDNF;SHC4;IRAK4;KIDINS220;PIK3R3;NTF3;CAMK2B;ZNF274
Thyroid hormone signaling pathwayFXYD2;FOXO1;ATP1A1;MAP2K1;NCOA1;ATP1A3;AKT1;PIK3R2;ITGB3
Amyotrophic lateral sclerosis (ALS)NEFM;GRIA1;NOS1;Casp3;SLC1A2;GRIN2C;ALS2;SOD1;CASP9
Huntingtons diseasePLCB3;COX4I1;PLCB4;SLC25A4;ATP5E;DCTN4;CREB3L1;NDUFA8;NDUFS2
Hepatitis CIFNA2;MAPK3;CLDN9;CLDN17;SOS1;IKBKE;TRAF2;Ifna15;Ifna11
Hepatitis BNFKBIA;NFATC1;HRAS;TBK1;MAP2K1;NFATC4;PIK3R2;NRAS;FASLG
MeaslesIL12B;IFNA7;TRP53;FYN;IRAK1;cgr2b;EIF2AK1;OAS2;IFNG
HTLV-I infectionCRTC2;PIK3R3;MSX1;RANBP3;TCF3;HLA-DMA;MAP2K4;POLE;WNT3
Herpes simplex infectionIL12B;TAF9B;IFNPHI1;IFNA16;BLB1;TRAF3;PPP1CB;CASP8;MAVS
Epstein-Barr virus infectionCDK1;EIF2AK4;RELB;ICAM1;TYK2;PSMD1;PSMD2;GSK3B;HSPA8
Pathways in cancerTFG;MAPK8;ERBB2;HSP90AB1;WNT7B;MTOR;MDM2;CCNE1;FN1
Transcriptional misregulation in cancerHIST1H3H;FLI1;EYA1;LYL1;CCNT2;IGFBP3;MAF;PAX8;HDAC1
Viral carcinogenesisGTF2E1;KAT2A;RBPJL;VAC14;HIST1H4L;HIST1H4B;IL6ST;HDAC7;TRADD
Proteoglycans in cancerSLC9A1;PRKCB;FZD6;NRAS;GAB1;FLNC;SDC4;Fasl;PIK3R1
MicroRNAs in cancerTRP53;HNRNPK;CCND1;HOXD10;TRIM71;TNXB;CCNE2;TNR;TNN
Colorectal cancerTCF7;MSH3;LEF1;CYCS;APC;MLH1;PIK3CG;SMAD2;GSK3B
Pancreatic cancerBAD;CDC42;TGFB3;PIK3R3;BRCA2;MAPK8;RAC2;ARHGEF6;RAD51
Endometrial cancerMAP2K1;ARAF;BAD;PDPK1;LEF1;CTNNA2;AKT2;PIK3R2;SOS1
GliomaPIK3R2;MAPK1;NRAS;SHC1;Pdgfa&Pdgfb;TP53;PIK3CG;CAMK2B;CAMK2D
Prostate cancerINS2;KRAS;PDPK1;CREB3L3;NDRG1;TP53;ATF4;PDGFB;ERBB2
Thyroid cancerTPM3;NRAS;RXRB;TCF7L2;CCDC6;TP53;HRAS;BRAF;CDH1
Basal cell carcinomaTCF7;WNT4;FZD9;APC;LEF1;BMP2;WNT8A;FZD6;WNT3A
MelanomaFgf15;FGF12;FGF5;BAD;CCND1;PIK3R2;PDGFC;PIK3R3;FGF3
Bladder cancerERBB2;CDKN2A;UPK3A;HBEGF;E2F2;IL-8;RPS6KA5;RASSF1;TRP53
Chronic myeloid leukemiaBRAF;CRK;IKBKG;MDM2;TP53;BCL2L1;STAT5B;AKT1;AKT2
Small cell lung cancerTRAF1;AKT2;LAMA1;RXRG;LAMB1;APAF1;LAMA5;PIK3R2;IKBKB
Non-small cell lung cancerRXRG;TP53;BAD;ALK;FOXO3;RB1;TGFA;CASP9;PIK3R1
Central carbon metabolism in cancerGLS2;SCO2;FGFR1;SIRT3;PDGFRB;PIK3CD;PTEN;FGFR3;SLC2A2

TP53 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP53 itself. We selected most functions TP53 had, and list some proteins which have the same functions with TP53. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRTCB;SMYHC2;ABCC1;EPHA4;UBE1Y1;MAP2K6;ULK2;ATP6V1BA;NLRC3
DNA bindingTHAP4;SSH2B;ZNF621;ZSCAN1;LYL1;HOXC13;GATA4;MECP2;MEIS2A
RNA polymerase II core promoter sequence-specific DNA bindingSPI1;GATA1;TAL1;RREB1;NSD1;NLRC5;MITF;MAZ;TFAP2A
RNA polymerase II transcription factor activity, sequence-specific DNA bindingATF5;ZSCAN18;FOXJ1;FOXN1;MEF2A;FOXI2;ETV4;ZNF576;SP3A
RNA polymerase II transcription factor bindingZGLP1;TBX20;ID4;TBX6;GFI1B;GATA3;GATA6;CREBBP;GATA2B
chaperone bindingHES1;PRNP;BAK1;DNAJB6;DNAJB4;HSPD1;HSPA5;GNB5;AHSA1L
chromatin bindingTCF7L1B;ARID5A;DNAJC2;HDAC5;KDM8;NFIA;MITF;HMGN5;KLF14
copper ion bindingCUTC;AOC3;DCT;TYR;LOXL2;PRND;PARK7;PRNP;HAMP
core promoter sequence-specific DNA bindingZFP750;H2AFY;NFYA;SOHLH2;ESR1;C1orf51;NR1D2;TP53;SIRT1
damaged DNA bindingTP53BP1;MGMT;CRY-DASH;TP73;POLD1;RAD1;XRCC1;RAD23B;OGG1
double-stranded DNA bindingDDX58;TP73;AIM2;RAD51D;RAD51B;TP63;NEIL3;TEF;RAD51
enzyme bindingHIST1H2AG;GOLPH3;DHCR24;WWOX;SLC12A3;PUS7;RPS2;ACAT1;HINFP
histone acetyltransferase bindingKAT2B;ZBTB7A;TRIP4;MTF1;TAF7;PAX6;GLI3;CITED2;TAF7L
histone deacetylase regulator activityNCOR1;MAPK8;TRP53;TP53
identical protein bindingCLDN23;PRDX3;MAP1S;NUFIP1;CCT7;CPT1A;RAD52;CRYAB;NLRC4
p53 bindingGSK3B;PSME3;ANKRD1;PTTG1IP;TP73;PLK3;ZMAT4;BCL2L12;USP10
protease bindingINS2;FLOT2;DVL3;SERPINC1;ITGB3;SRI;SERPINA1E;Serpina1c;NDUFS7
protein N-terminus bindingPEX14;NCOR2;ALOX5AP;MORF4L1;YWHAQ;RBPJ;GTF2H3;TAF11;SCFD1
protein bindingLPAR2;CD276;MTAP1A;KLKB1;MAP4K3;ELK3;FABP5;FAAH;DDX39B
protein heterodimerization activityHIST4H4;HIST1H3D;SDCBP;FLOT1;HIST1H2BN;SYT5;SMC2;HIST1H47;HIST1H2BO
protein kinase bindingFAM83D;TPX2;USF1;RELA;CACNB3;APC;SV2A;TRPV4;GRB2
protein phosphatase 2A bindingPTPN1;TRP53;ARPP19;ANKLE2;CTTNBP2NL;BCL2;SPHK1;HMGCR;GRIN3A
protein phosphatase bindingRPA2;TRAF2;GRB2;PPP6R3;JAK3;CDH5;PPME1;PIK3R1;EGFR
protein self-associationL1CAM;AGTR1A;CNTN2;MDH2;RYR2;SHANK3;TMEM43;SVIP;TP53
receptor tyrosine kinase bindingPIK3R2;DOCK4;PCNA;ANGPT1;ANGPT2;PLCG1;PITPNM3;PTPN2;FLT3LG
sequence-specific DNA bindingZSCAN23;ZNF193;PKNOX1;HOXB13A;NR2F2;ZNF215;HOXC13A;ATF5A;DLX4
transcription factor activity, sequence-specific DNA bindingHES6;PROX1;CEBPD;FOXI3A;MYPOP;CNOT8;HIF1A;STAT5B;TP63
transcription factor bindingRNF19A;PURB;GTF2A1;IFI16;NFATC2;JUNBA;EGR1;CEBPB;HES4
transcription regulatory region DNA bindingLEF1;ATMIN;DDIT3;SREBF1;KLF1;ZNF831;DLX5;CTNNB1;GABPA
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingRBPJ;HNRNPK;KCNA3;HNF1A;CREB3L1;SOX12;MIXL1;SFPI1;SOX4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingHIF1A;ATF1;MYF6;GATA3;GATA2;CREB3L4;OSR2;ELF5;NHLH1
ubiquitin protein ligase bindingDNAJA1;RPA3;DAXX;HERC2;AICDA;UBXN6;SCN5A;TSG101;GABARAPL1
zinc ion bindingADAM2;MICAL2;ZRANB2;UMPS;GTF2B;THRB;MTF2;DNLZ;NBR1

TP53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP53 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP53.

MDM2

Research Area

Related articles

Sadahira, Y; Sugihara, T; et al. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome. VIRCHOWS ARCHIV 466:343-350(2015).
Fuentes-Raspall, MJ; Caragol, I; et al. Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism. APOPTOSIS 20:371-382(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
02/26/2023

    By actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the TP53 protein.

    11/05/2020

      This flexibility allows for tailored approaches and provides researchers with more options to study specific aspects of TP53 biology or its interactions with other molecules.

      07/24/2017

        Manufacturers can provide comprehensive product information, including data on the functionality, stability, and handling of TP53 protein.

        Q&As (5)

        Ask a question
        Can TP53 status be used for cancer risk assessment and screening in individuals with a family history of cancer? 07/21/2022

        Yes, identifying TP53 mutations in families with a history of early-onset cancers can help identify individuals at high risk for cancer and guide screening and prevention strategies.

        What are the challenges in developing targeted therapies for TP53-mutated cancers? 05/21/2019

        TP53 mutations are highly diverse, making it challenging to develop a one-size-fits-all therapy. Additionally, the p53 pathway is complex, and disrupting it can have unintended consequences.

        Can TP53 status influence eligibility for certain clinical trials? 12/06/2018

        Yes, TP53 mutation status can be a criterion for eligibility in specific clinical trials, especially those testing experimental treatments that may target the p53 pathway.

        How might TP53 status affect decisions regarding surgery, chemotherapy, and radiation therapy? 08/13/2017

        TP53 status can influence treatment decisions. For example, patients with TP53 mutations may require more aggressive treatment approaches or different chemotherapy regimens.

        Are there targeted therapies specifically designed for TP53-mutated cancers? 06/05/2016

        Currently, there are no specific targeted therapies approved solely for TP53-mutated cancers. However, research is ongoing to develop drugs that target the altered p53 pathway.

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