Recombinant Human TP53 Protein, His-tagged

• Cat.No.: TP53-983H
• Product Overview: Recombinant human tumor protein p53 with a N-terminal 6x histidine tag was derived from E.coli

Specification

• Description: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 46.3 kDa
• Purity: > 90%
• Notes: This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use.
• Storage: Upon arrival, the protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store at -20 centigrade or -80 centigrade in appropriate aliquots. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as a 0.2 μm filtered solution in 6 M urea, 10 mM Tris-HCl (pH 8.0), 0.5 M imidazole.
• Shipping: Ice packs

Gene Information

• Gene Name: TP53 tumor protein p53 [ Homo sapiens (human) ]
• Official Symbol: TP53
• Synonyms: TP53; tumor protein p53; P53; BCC7; LFS1; BMFS5; TRP53; cellular tumor antigen p53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; tumor protein 53; tumor supressor p53
• Gene ID: 7157
• mRNA Refseq: NM_000546
• Protein Refseq: NP_000537
• MIM: 191170
• UniProt ID: P04637