Recombinant Human Tumor Protein P53, GST-tagged
Cat.No. : | TP53-325H |
Product Overview : | Recombinant full-length human p53 was expressed by baculovirus in Hi5 cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TP53-325H |
Description : | TP53 is a key regulator of cell growth and acts as a tumor suppressor gene. Wild-type TP53 gene can suppress transformation of rat embryo fibroblasts in cell culture by other oncogenes such as the adenovirus E1A and Ras. DNA tumor viruses such as SV40 large T antigen and the adenovirus E1A plus E1B-55Kd proteins bind to TP53 and inactivate its tumor suppressor activities leading to cellular transformation. Mutational inactivation of the TP53 gene is detected in more than 50% of human cancers. Mutation of TP53 renders cancer cells more resistant to current cancer therapies due to lack of TP53-mediated apoptosis. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 79 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol. |
Purity : | > 95 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TP53 tumor protein p53 [ Homo sapiens ] |
Official Symbol : | TP53 |
Synonyms : | TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53 |
Gene ID : | 7157 |
mRNA Refseq : | NM_00546 |
Protein Refseq : | NP_000537 |
MIM : | 191170 |
UniProt ID : | P04637 |
Chromosome Location : | 17p13.1 |
Function : | ATP binding; DNA strand annealing activity; chaperone binding; chromatin binding; copper ion binding; enzyme binding; metal ion binding; promoter binding; protein N-terminus binding; protein heterodimerization activity; transcription factor activity; transcription factor binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
TP53-4893H | Recombinant Human TP53 (Y220C) Protein, Myc/DDK-tagged | +Inquiry |
TP53-2235H | Recombinant Human TP53 Protein, His (Fc)-Avi-tagged | +Inquiry |
TP53-2773H | Recombinant Human TP53 Protein, His-tagged | +Inquiry |
TP53-2548H | Recombinant Human TP53 protein(101-310 aa), N-MBP & C-His-tagged | +Inquiry |
TP53-18H | Active Recombinant Human TP53 R175H (HLA-A*02:01) Tetramer Protein, C-His/Avi tagged | +Inquiry |
◆ Lysates | ||
TP53-860HCL | Recombinant Human TP53 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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