UBE2I
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Official Full Name
ubiquitin-conjugating enzyme E2I
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Overview
UBC9 is a member of the E2 ubiquitin-conjugating enzyme family that is involved in ubiquitin-dependent protein degradation system (1). Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UBC9 can function as a co-factor of PLAGL2, uncoupling its enzymatic activity to mediate PLAGL2 interactive SP-C promoter activity (2). UBC9 also plays an important role in the up-regulation of the bone morphogenetic protein signaling pathway. -
Synonyms
UBE2I; ubiquitin-conjugating enzyme E2I; ubiquitin conjugating enzyme E2I (homologous to yeast UBC9) , ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast); SUMO-conjugating enzyme UBC9; UBC9; SUMO-protein ligase; SUMO-1-protein ligase; ubiquitin-protein ligase I; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-protein ligase E2I; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); P18; C358B7.1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UBE2I Related Articles
- UBE2I Related Research Area
- UBE2I Related Signal Pathway
UBE2I involved in several pathways and played different roles in them. We selected most pathways UBE2I participated on our site, such as RNA transport, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2I were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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RNA transport | KPNB1;POM121L2;NMD3;EIF3E;NUP37;EIF3BA;EIF5;NUP153;PRMT5 |
NF-kappa B signaling pathway | BTK;MAP3K7IP3;TNFRSF13C;CXCL2;TLR4;Ccl21a;PRKCB;PIAS4;GM10591 |
Ubiquitin mediated proteolysis | PRPF19;PIAS2;TCEB1;SMURF1;SOCS1;UBE1Y1;PIAS1;UBE2J1;UBE2O |
MicroRNAs in cancer | ABL1;PLCG2;CDC25A;ITGB3;HOXD10;PRKCA;VEGFA;CCNE1;DDIT4 |
UBE2I has several biochemical functions, for example, ATP binding, HLH domain binding, RING-like zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2I itself. We selected most functions UBE2I had, and list some proteins which have the same functions with UBE2I. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | G3BP1;CDC7;RTEL1;PAK2A;PPIP5K1;UBE2D2A;ABCD3A;PRKCA;CMPK1 |
HLH domain binding | SIRT1;UBE2I;PKD2 |
RING-like zinc finger domain binding | BMI1;UBE2I;RNF2 |
SUMO conjugating enzyme activity | |
SUMO transferase activity | TOPORS;SUMO3;UBE2I;UBE2IB;MUL1;UBE2IA;PIAS4;NSMCE2;CBX4 |
enzyme binding | PCCA;RXRA;H2AFX;UGT1A6B;NOS1;TOP2B;GNB2L1;DAXX;CDC20 |
ligase activity | CDC34B;RFWD3;BRAP;PRPF19;RNF187;MARCH6;UBR2;MARCH4;TRIM11 |
poly(A) RNA binding | FAM50A;NOL11;SNRPA1;RBMX2;TRIM25;MRPL40;JUN;PTCD1;MAZ |
protein binding | PAX9;CCNA2;U2AF2;QKI;PDIA4;RITA1;ELK4;PDLIM5;HIST1H2AL |
transcription factor binding | NKX2-1;HEY1;FOXC1;MED6;MAPK1;ZBTB49;NAB2;RBL1;GATA4 |
NOT ubiquitin protein ligase activity | UBE2I;UBE2M;UBE2IB;UBE2F;VHLL;UBE2IA |
NOT ubiquitin protein ligase binding | UBE2IA;UBE2M;UBE2I;UBE2F;UBE2IB |
UBE2I has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2I here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2I.
RANGAP1; SUMO1; PIAS2
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