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UCHL3

  • Official Full Name

    ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

  • Overview

    The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are;proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the;mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to;regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that;encode different protein isoforms.
  • Synonyms

    UCHL3; ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L3; ubiquitin thiolesterase; ubiquitin thioesterase L3; UCH-L3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UCHL3-180H Active Recombinant Human UCHL3, GST-tagged E.coli GST
Human UCHL3-1518H Recombinant Human UCHL3, His-tagged Human His
Human UCHL3-169H Recombinant Human UCHL3 E.coli N/A
Human UCHL3-3090H Active Recombinant Human UCHL3 protein, His-tagged E.coli His Glu2-Ala230
Human UCHL3-534HCL Recombinant Human UCHL3 293 Cell Lysate HEK293 N/A
Human UCHL3-1954H Recombinant Human UCHL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UCHL3-0361H Recombinant Human UCHL3 Protein (E2-A230), His tagged E.coli His E2-A230
Human UCHL3-0362H Recombinant Human UCHL3 Protein (E2-A230), Tag Free E.coli No tag E2-A230
Human CAB11622RH Rabbit Monoclonal Antibody to Human Ubiquitin Carboxyl-Terminal Esterase L3 Rabbit N/A
Human UCHL3-1197HFL Recombinant Full Length Human UCHL3 Protein, C-Flag-tagged Mammalian cells Flag
Human UCHL3-2303H Recombinant Human UCHL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human UCHL3-2303H-B Recombinant Human UCHL3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Uchl3-4073M Active Recombinant Mouse UCHL3 protein, His-tagged E.coli His Glu2-Ala230
Mouse Uchl3-6820M Recombinant Mouse Uchl3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat UCHL3-6419R Recombinant Rat UCHL3 Protein Mammalian Cell His
Rat Uchl3-1810R Recombinant Rat UCHL3 protein(Glu2-Ala230), His-tagged E.coli N-His Glu2-Ala230
Rat Uchl3-609R Recombinant Rat Uchl3 Protein, His-tagged E.coli His Glu2~Ala230
Rat UCHL3-6075R Recombinant Rat UCHL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UCHL3-6075R-B Recombinant Rat UCHL3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque UCHL3-5086R Recombinant Rhesus monkey UCHL3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque UCHL3-4899R Recombinant Rhesus Macaque UCHL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque UCHL3-4899R-B Recombinant Rhesus Macaque UCHL3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish UCHL3-3009Z Recombinant Zebrafish UCHL3 Mammalian Cell His
Chicken UCHL3-6388C Recombinant Chicken UCHL3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UCHL3 involved in several pathways and played different roles in them. We selected most pathways UCHL3 participated on our site, such as Proteasome Degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteasome DegradationLRRC41;HECTD3;ASB9;RNF123;RNF4;UBE2V1;STUB1;ASB7;ASB11

UCHL3 has several biochemical functions, for example, peptidase activity, protein binding, ubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL3 itself. We selected most functions UCHL3 had, and list some proteins which have the same functions with UCHL3. You can find most of the proteins on our site.

Function Related Protein
peptidase activityUSP27X;Gzmg;ELA2L;MASP2;KLK1B24;FAP;ST14A;MMP23BB;CAPN2L
protein bindingSHISA5;ITGA7;NCOR2;LGI1;TNFAIP8L2;SERPINA1A;CD200R1;OPRM1;ZNF232
ubiquitin bindingAUP1;SMAD3;SPRTN;OTUB1;FAF2;UBE2N;TOP2A;USP5;VPS28
ubiquitin-specific protease activityATXN3L;CYLD;USP43A;USP17L5;USP31;USP38;USP3;UFD1L;OTUD5

UCHL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL3.

UBB; Smad1; SMAD1; COPS6; COPS5; CLPB; USP20; ATXN7L3; POGK; NSG2; pi3p

Research Area

Related articles

Sarveswari, S; Vijayakumar, V; et al. Synthesis of 4-Hydroxy-2(1H)-Quinolone Derived Chalcones, Pyrazolines and Their Antimicrobial, In Silico Antimalarial Evaluations. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:43-64(2015).
Hung, FF; To, WP; et al. Water-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties. CHEMISTRY-A EUROPEAN JOURNAL 20:8604-8614(2014).
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