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UCP1

  • Official Full Name

    uncoupling protein 1 (mitochondrial, proton carrier)

  • Overview

    Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
  • Synonyms

    UCP1; uncoupling protein 1 (mitochondrial, proton carrier); UCP; mitochondrial brown fat uncoupling protein 1; SLC25A7; mitochondrial brown fat uncoupling protein; Solute carrier family 25 member 7; Thermogenin; UCP 1; UCP1_HUMAN; Uncoupling protein 1; OTTHUMP00000164611;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Dicrostonyx groenlandicus (Northern collared lemming)
  • Homo sapiens (Human)
  • Human
  • Mesocricetus auratus (Golden hamster)
  • Mouse
  • Mus musculus (Mouse)
  • Ochotona dauurica (Daurian pika)
  • Oryctolagus cuniculus (Rabbit)
  • Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster)
  • Rat
  • Rattus norvegicus (Rat)
  • Suncus murinus (Asian house shrew) (Musk shrew)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UCP1-46H Recombinant Human UCP1 protein, GST-tagged Wheat Germ GST
Human UCP1-9176H Recombinant Human UCP1, His-tagged E.coli His 96-185a.a.
Human UCP1-526HCL Recombinant Human UCP1 293 Cell Lysate, Flag-tagged HEK293 Flag
Human UCP1-1552H Recombinant Human UCP1 Protein (2-307 aa), His-tagged Yeast His 2-307 aa
Human UCP1-6539H Recombinant Human UCP1 Protein E.coli Tag Free
Human UCP1-2916H Recombinant Human UCP1 protein, His-tagged E.coli His 1-307 aa
Human UCP1-846H Recombinant Human UCP1 Protein (2-307 aa), His-SUMO-tagged E.coli His/SUMO 2-307 aa
Mouse UCP1-12M Recombinant Mouse UCP1 protein, His-tagged E.coli His
Mouse UCP1-17789M Recombinant Mouse UCP1 Protein Mammalian Cell His
Mouse UCP1-20M Recombinant Mouse Ucp1 protein, His-tagged E.coli His Pro179~Leu296
Mouse UCP1-9872M Recombinant Mouse UCP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UCP1-9872M-B Recombinant Mouse UCP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ucp1-281M Recombinant Mouse Ucp1 Protein, His-tagged E.coli His Pro179~Leu296
Rat UCP1-27R Recombinant Rat UCP1 protein, His-tagged E.coli His
Rat UCP1-28R Recombinant Rat UCP1 protein, His/GST-tagged E.coli His/GST
Rat UCP1-6421R Recombinant Rat UCP1 Protein Mammalian Cell His
Rat UCP1-6077R-B Recombinant Rat UCP1 Protein Pre-coupled Magnetic Beads HEK293
Rat UCP1-6077R Recombinant Rat UCP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ucp1-283R Recombinant Rat Ucp1 Protein, His/GST-tagged E.coli His/GST Pro179~Leu296
Bos taurus (Bovine) RFL20829BF Recombinant Full Length Bovine Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-288)
Canis lupus familiaris (Dog) (Canis familiaris) RFL7527CF Recombinant Full Length Dog Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-309)
Dicrostonyx groenlandicus (Northern collared lemming) RFL35513DF Recombinant Full Length Dicrostonyx Groenlandicus Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-307)
Homo sapiens (Human) RFL19243HF Recombinant Full Length Human Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-307)
Mesocricetus auratus (Golden hamster) RFL17255MF Recombinant Full Length Mesocricetus Auratus Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-307)
Mus musculus (Mouse) RFL25785MF Recombinant Full Length Mouse Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-307)
Ochotona dauurica (Daurian pika) RFL241OF Recombinant Full Length Ochotona Daurica Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-306)
Oryctolagus cuniculus (Rabbit) RFL24001OF Recombinant Full Length Rabbit Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-306)
Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster) RFL7801PF Recombinant Full Length Phodopus Sungorus Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-307)
Rattus norvegicus (Rat) RFL9919RF Recombinant Full Length Rat Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-307)
Suncus murinus (Asian house shrew) (Musk shrew) RFL31135SF Recombinant Full Length Suncus Murinus Mitochondrial Brown Fat Uncoupling Protein 1(Ucp1) Protein, His-Tagged E.coli expression system His Full Length (1-308)
Zebrafish UCP1-9931Z Recombinant Zebrafish UCP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UCP1 Related Articles
  • UCP1 Related Research Area

UCP1 involved in several pathways and played different roles in them. We selected most pathways UCP1 participated on our site, such as PPAR signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayCYP4A10;ACADL;FABP7A;FABP7;PCK1;ACOX3;ILK;ACSL5;PPARDB
Huntingtons diseaseATP5G3;ATP5B;ITPR1;DNAL4;ATP5H;COX7A2;POLR2J;SLC25A31;POLR2K

UCP1 has several biochemical functions, for example, oxidative phosphorylation uncoupler activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCP1 itself. We selected most functions UCP1 had, and list some proteins which have the same functions with UCP1. You can find most of the proteins on our site.

Function Related Protein
oxidative phosphorylation uncoupler activityUCP3;UCP1

UCP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCP1.

Brestoff, JR; Kim, BS; et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. NATURE 519:242-+(2015).
Maimaitiyiming, H; Norman, H; et al. CD47 Deficiency Protects Mice From Diet-induced Obesity and Improves Whole Body Glucose Tolerance and Insulin Sensitivity. SCIENTIFIC REPORTS 5:-(2015).
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Reviews
05/14/2020

    Standardized usage protocols of protein reagents facilitate data sharing and comparison with other laboratories.

    06/22/2019

      The application process of protein reagents is convenient, requiring minimal complex sample handling steps.

      03/11/2017

        Protein reagents possess high purity, guaranteeing reliable results without interference from impurities.

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