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ULK1

  • Official Full Name

    unc-51-like kinase 1

  • Overview

    Two related serine/threonine kinases, UNC-51-like kinase 1 and 2 (ULK1, ULK2), were discovered as mammalian homologs of the C. elegans gene UNC-51 in which mutants exhibited abnormal axonal extension and growth. Both proteins are widely expressed and cont
  • Synonyms

    ULK1; unc-51-like kinase 1 (C. elegans); unc 51 (C. elegans) like kinase 1; serine/threonine-protein kinase ULK1; ATG1; ATG1 autophagy related 1 homolog (S. cerevisiae); ATG1A; ATG1 autophagy related 1 homolog; autophagy-related protein 1 homolog; UNC51;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Free Style 293-F Cell
  • HEK293
  • HEK293T
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Sf9 Insect Cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • 6×His
  • C
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ULK1-1507H Active Recombinant Human ULK1, GST-tagged Sf9 Insect Cell GST 1-649 aa
Human ULK1-13H Active Recombinant Human ULK1 Protein, 1-314, N-6×His tagged Insect cells N-6×His 1-314
Human ULK1-10H Active Recombinant Human ULK1 protein, GST&Strep II-Tagged Sf9 Insect Cells N-GST&C-Strep II M1-A280
Human ULK1-254H Active Recombinant Human ULK1(1-314) Protein, N-His-tagged Sf21 His 1-314 aa
Human ULK1-255H Recombinant Human Unc-51-Like Kinase 1 (C. elegans), GST-tagged, Active Sf9 Insect Cell GST
Human ULK1-568H Recombinant Human ULK1 protein, FLAG-tagged Free Style 293-F Cell Flag
Human ULK1-31666TH Recombinant Human ULK1, FLAG-tagged Flag 1049 amino acids
Human ULK1-505HCL Recombinant Human ULK1 293 Cell Lysate HEK293 N/A
Human ULK1-557H Recombinant Human ULK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ULK1-275HFL Recombinant Full Length Human ULK1 Protein, C-Flag-tagged Mammalian cells Flag
Human ULK1-6023H Recombinant Human ULK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ULK1-2313H Recombinant Human ULK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ULK1-2313H-B Recombinant Human ULK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ULK1-17831M Recombinant Mouse ULK1 Protein Mammalian Cell His
Mouse ULK1-9903M-B Recombinant Mouse ULK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ULK1-9903M Recombinant Mouse ULK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ulk1-6830M Recombinant Mouse Ulk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ULK1 Related Articles

ULK1 involved in several pathways and played different roles in them. We selected most pathways ULK1 participated on our site, such as Regulation of autophagy, mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of autophagyIFNA4;ATG4C;IFNA6;IFNPHI3;GABARAPL2;IFNG1-2;IFNA12;PIK3R4;IFNA5
mTOR signaling pathwayHIF1A;PIK3R5;RB1CC1;INS1;CAB39;PIK3CA;EIF4BB;PIK3CD;TSC2
AMPK signaling pathwayG6PC2;G6PC;PPP2R2B;RPS6KB1;CPT1B;STRADA;CCND1;RAB2A;PPP2R3A

ULK1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK1 itself. We selected most functions ULK1 had, and list some proteins which have the same functions with ULK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKLHL8;LIG4;FUK;OXSR1B;PTK6;CDK3;ATP2B1;WNK1;ATP1A1A.1
Rab GTPase bindingEHD1;ZFYVE20;AP3M1;PDE6D;RABGGTB;RAB3GAP1;CFAP45;RAB11FIP5;EXPH5
protein bindingRAD52;UBE2A;ANXA10;PTGER4;PPP3R2;DPM1;TP73;ADAM10;METTL9
protein complex bindingDISC1;CEBPA;TUB;STRN4;PPP4C;BAX;CAPG;AKAP5;MYSM1
protein serine/threonine kinase activityPRKCQ;SLK;ALPK1;NUAK2;SRPK2;RIPK1;MAP4K5;TNK2;SBK3

ULK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK1.

RB1CC1; GABARAP; GABARAPL2; ATG13; MAP1LC3C; MAP1LC3B; GABARAPL1

Osaka, M; Ito, D; et al. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 24:1617-1629(2015).
Ribas, VT; Schnepf, B; et al. Early and Sustained Activation of Autophagy in Degenerating Axons after Spinal Cord Injury. BRAIN PATHOLOGY 25:157-170(2015).
  • Q&As
  • Reviews

Q&As (7)

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How does ULK1 interact with other autophagy-related proteins? 03/01/2021

ULK1 interacts with several autophagy-related proteins, including ATG13, FIP200, and ATG101, forming a complex that is essential for the initiation of autophagy.

Are there any known upstream regulators of ULK1 activity? 09/02/2019

mTOR (mechanistic target of rapamycin) is a known upstream regulator of ULK1. When nutrients are abundant, mTOR is active and inhibits ULK1. Conversely, under nutrient starvation, mTOR is inactivated, leading to ULK1 activation and initiation of autophagy.

What is the primary function of the ULK1 protein in cellular processes? 07/27/2019

ULK1 is a serine/threonine-protein kinase that plays a crucial role in the initiation of autophagy, a cellular process responsible for the degradation and recycling of cellular components.

What are the implications of ULK1 dysregulation in diseases like cancer? 07/07/2019

Dysregulation of ULK1 can lead to impaired autophagy, which has been implicated in several diseases, including cancer. Overactive or underactive ULK1 can disrupt cellular homeostasis and contribute to tumorigenesis.

Are there any known post-translational modifications of ULK1 that influence its activity? 01/02/2019

ULK1 undergoes several post-translational modifications, including phosphorylation and ubiquitination, which can either activate or inhibit its kinase activity and, consequently, its role in autophagy.

How does ULK1 play a role in the initiation of autophagy? 09/29/2018

ULK1 is part of a complex that is essential for the initiation of autophagy. Upon activation, ULK1 phosphorylates several targets, leading to the nucleation and formation of the autophagosome.

How does ULK1 activity relate to nutrient availability in cells? 07/06/2018

ULK1 activity is sensitive to nutrient availability. Under nutrient-rich conditions, ULK1 is inhibited, while under nutrient-deprived conditions, ULK1 becomes activated, promoting autophagy to recycle cellular components and generate energy.

Customer Reviews (3)

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Reviews
08/06/2022

    Reliable results, will reorder.

    06/07/2021

      Affordable and high-quality.

      09/30/2019

        Met all my expectations.

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