USP2

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USP2

Official Full Name ubiquitin specific peptidase 2
Background This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Synonyms USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • FLAG
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human USP2-092H Recombinant Human USP2 Protein, His-tagged E. coli His
    Human USP2-011H Recombinant Human USP2 Protein, His-tagged E.coli His
    Human USP2-1042H Recombinant Human USP2 E.coli N/A
    Human USP2-153H Recombinant Human USP2, His-tagged E.coli His
    Human USP2-182H Recombinant Human USP2, GST-tagged E.coli GST
    Human USP2-320H Recombinant Human USP2 protein, FLAG-tagged Insect Cell FLAG
    Human USP2-3620H Recombinant Human USP2, GST-tagged E.coli GST
    Human USP2-468HCL Recombinant Human USP2 293 Cell Lysate HEK293 N/A
    Human USP2-544H Recombinant Human USP2 Protein, His-tagged E.coli His
    Human USP2-886H Recombinant Human USP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Usp2-106M Recombinant Mouse Usp2 Protein, His-tagged E.coli His
    Mouse USP2-17909M Recombinant Mouse USP2 Protein Mammalian Cell His
    Mouse Usp2-6868M Recombinant Mouse Usp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat USP2-6473R Recombinant Rat USP2 Protein Mammalian Cell His
    Rat Usp2-694R Recombinant Rat Usp2 protein E.coli N/A
    Rhesus Macaque USP2-5124R Recombinant Rhesus monkey USP2 Protein, His-tagged Mammalian Cell His
    Chicken USP2-6487C Recombinant Chicken USP2 Mammalian Cell His

    USP2 involved in several pathways and played different roles in them. We selected most pathways USP2 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Death Receptor Signalling RNF31; SHRPRBCK1R; SHARPIN; TAX1BP1; OTULIN; FAM105B; GNB2L1; OTULINB; TAX1BP1B; RBCK1
    Regulation of TNFR1 signaling RNF31; SHRPRBCK1R; SHARPIN; OTUD7B; CLIP3; OTULINB; USP2; RBCK1; USP4; TAX1BP1
    Signal Transduction HECW1; ADM2; RDH14; GHRH; ROR1; DCLRE1B; RDH14A; OR56A1; KIF7; KLHL12
    TNF signaling TAX1BP1B; SHARPIN; CLIP3; OTUD7B; OTULIN; RNF31; USP2; SHRPRBCK1R; FAM105B; RBCK1
    TNF-alpha/NF-kB Signaling Pathway USP2; SMARCE1; RNF25; COMMD1; TANK; SMARCB1; KTN1; DAP; PFDN2; CRADD
    TNFR1-induced NFkappaB signaling pathway USP4; RNF31; OTUD7B; USP2; SHARPIN; SHRPRBCK1R
    TNFR1-induced proapoptotic signaling OTUD7B; USP2; USP4

    USP2 has several biochemical functions, for example, cyclin binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP2 itself. We selected most functions USP2 had, and list some proteins which have the same functions with USP2. You can find most of the proteins on our site.

    Function Related Protein
    cyclin binding PFTK1; MDFIC; CDK2; FBXW7; CDK6; HDAC3; CDKN1A; CDK5RAP3; CDK14; PTCH1
    cysteine-type endopeptidase activity SFRP1; USP6; CASP2; USP47; CASPB; ATG4C; USP22; CASP9; USP28; CTSBB
    identical protein binding GOT2A; AKT1; CEP72; SERPINA1E; ZNF3; CXADR; GOT1; NELL2; MVK; HOMER1
    metal ion binding ZNF750; UNK; ZNF548; VDRB; GNAI3; SMAD4; CYB5A; MYLIPA; CYB5D1; GALNT9
    protein binding DAAM1; KIR2DL4; S100A12; SERPINA5; DDC; BCAR1; HIST1H4F; ATM; FAM207A; SNX20
    ubiquitin protein ligase binding TRAF2; PCBP2; TRAF5; HSPD1; XRCC5; RNF31; FAF2; UBE2O; CHEK2; BAG5
    ubiquitin-specific protease activity USP13; USP24; BAP1; UCHL1; USP30; USP46; EIF3F; USP7; USP8; USP3

    USP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP2.

    KRT15; TRAF2; HOMER3; NEFL; TRIM27; GOLGA2

    Stes, E; Laga, M; et al. A COFRADIC Protocol To Study Protein Ubiquitination. JOURNAL OF PROTEOME RESEARCH 13:3107-3113(2014).
    Husted, RF; Lu, HY; et al. Oxygen regulation of the epithelial Na channel in the collecting duct. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F412-F424(2011).

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