USP2 Protein


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Official Full Name ubiquitin specific peptidase 2
Background This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Synonyms USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • FLAG
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human USP2-1042H Active Recombinant Human USP2 E.coli N/A Inquiry
    Human USP2-182H Active Recombinant Human USP2, GST-tagged E.coli GST Inquiry
    Human USP2-320H Active Recombinant human USP2 protein, FLAG-tagged Sf9 Insect Cell FLAG Inquiry
    Human USP2-544H Active Recombinant Human USP2 Protein, His-tagged E.coli His Inquiry
    Human USP2-153H Recombinant Human USP2, His-tagged E.coli His Inquiry
    Human USP2-3620H Recombinant Human USP2, GST-tagged E.coli GST Inquiry
    Mouse Usp2-106M Recombinant Mouse Usp2 Protein, His-tagged E.coli His Inquiry
    Mouse USP2-17909M Recombinant Mouse USP2 Protein Mammalian Cell His Inquiry
    Rat USP2-6473R Recombinant Rat USP2 Protein Mammalian Cell His Inquiry
    Rat Usp2-694R Recombinant Rat Usp2 protein E.coli N/A Inquiry
    Rhesus Macaque USP2-5124R Recombinant Rhesus monkey USP2 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken USP2-6487C Recombinant Chicken USP2 Mammalian Cell His Inquiry
    Human USP2-468HCL Recombinant Human USP2 293 Cell Lysate HEK293 N/A Inquiry
    Human USP2-092H Recombinant Human USP2 Protein, His-tagged E. coli His Inquiry
    Human USP2-011H Recombinant Human USP2 Protein, His-tagged E.coli His Inquiry
    Human USP2-886H Recombinant Human USP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Usp2-6868M Recombinant Mouse Usp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    USP2 involved in several pathways and played different roles in them. We selected most pathways USP2 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Death Receptor Signalling OTULIN; USP4; USP2; SHRPRBCK1R; FAM105B; TAB1; SHARPIN; OTUD7B; TAX1BP1; OTULINB
    Regulation of TNFR1 signaling CLIP3; SHRPRBCK1R; USP2; OTULINB; OTULIN; TAX1BP1; USP4; FAM105B; TAX1BP1B; OTUD7B
    Signal Transduction RHPN1; EVC; GRAP; OXER1; NOXA1; OPN1LW2; HEBP1; DHRS3A; NCKIPSD; ARHGAP6
    TNF-alpha/NF-kB Signaling Pathway DCAF7; TANK; COMMD1; KPNA6; NR2C2; SMARCB1; MARK2; DDX3X; MCC; ZFAND5
    TNFR1-induced NFkappaB signaling pathway OTUD7B; SHARPIN; USP2; SHRPRBCK1R; RNF31; USP4
    TNFR1-induced proapoptotic signaling USP4; USP2; OTUD7B

    USP2 has several biochemical functions, for example, cyclin binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP2 itself. We selected most functions USP2 had, and list some proteins which have the same functions with USP2. You can find most of the proteins on our site.

    Function Related Protein
    cyclin binding CDK2; CDK5RAP3; CDK14; CDK12; CUL3; CDK6; HDAC3; INCA1; PFTK1; MDFIC
    cysteine-type endopeptidase activity USP17L5; USP42; FMNL3; PDIA3; UCHL1; USP13; USP16; CASPA; CTSLL; USP51
    identical protein binding KCNJ2; DVL1; SH2B2; PTS; GLUD1; SNRNP200; KCNJ10; MTPAP; RBM10; DNM1L
    metal ion binding COL27A1A; PLEKHM1; ZNF354B; PRKCBB; ZDHHC14; PLRDGB; AOX4; NUDT10; NT5C2B; DUS3L
    protein binding NRP1B; TAF12; LCMT2; ZNF511; CCDC36; INPP5B; GNE; PPM1K; SLC9A3; KLRB1B
    ubiquitin protein ligase binding SPOP; PINK1; ARRB1; IKBKE; PCBP2; CUL3B; TRAF5; TPI1; UBOX5; UBE2G1B
    ubiquitin-specific protease activity USP17L2; USP9X; IWS1; OTUB1; FMNL3; USP27X; USP12A; OTUD5A; USP7; USP47

    USP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP2.


    Stes, E; Laga, M; et al. A COFRADIC Protocol To Study Protein Ubiquitination. JOURNAL OF PROTEOME RESEARCH 13:3107-3113(2014).
    Husted, RF; Lu, HY; et al. Oxygen regulation of the epithelial Na channel in the collecting duct. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F412-F424(2011).

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