• Official Full Name

    ubiquitin specific peptidase 2

  • Background

    This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Synonyms

    USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • FLAG
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken USP2-6487C Recombinant Chicken USP2 Mammalian Cell His
    Human USP226316H Recombinant Human USP2 (258-605) Protein
    Human USP2-182H Active Recombinant Human USP2, GST-tagged E.coli GST
    Human USP2-153H Recombinant Human USP2, His-tagged E.coli His
    Human USP2-468HCL Recombinant Human USP2 293 Cell Lysate HEK293 N/A
    Human USP226345H Recombinant Human USP2 (260-605)-GSGSGS-FLAG-Ubiquitin (1-71) (E472A, K473A) Protein
    Human USP2-544H Active Recombinant Human USP2 Protein, His-tagged E.coli His
    Human USP2-320H Active Recombinant human USP2 protein, FLAG-tagged Sf9 Insect Cell FLAG
    Human USP2-3620H Recombinant Human USP2, GST-tagged E.coli GST
    Human USP216623H Recombinant Human USP2 (260-605)-GSGSGSTNTRPTNYPG-Ubiquitin (1-71) (E472A, K473A) Protein
    Human USP2-011H Recombinant Human USP2 Protein, His-tagged E.coli His
    Human USP2-092H Recombinant Human USP2 Protein, His-tagged E. coli His
    Human USP2-1042H Active Recombinant Human USP2 E.coli N/A
    Human USP2-0550H Recombinant Human USP2 Protein (N259-M605), His tagged E.coli His
    Human USP2-0551H Recombinant Human USP2 Protein (N259-M605), Tag Free E.coli No tag
    Human USP2-886H Recombinant Human USP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse USP2-17909M Recombinant Mouse USP2 Protein Mammalian Cell His
    Mouse Usp2-106M Recombinant Mouse Usp2 Protein, His-tagged E.coli His
    Mouse USP2-9951M Recombinant Mouse USP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse USP2-9951M-B Recombinant Mouse USP2 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Usp2-6868M Recombinant Mouse Usp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat USP2-6473R Recombinant Rat USP2 Protein Mammalian Cell His
    Rat USP2-6129R-B Recombinant Rat USP2 Protein Pre-coupled Magnetic Beads HEK293
    Rat Usp2-694R Recombinant Rat Usp2 protein E.coli N/A
    Rat USP2-6129R Recombinant Rat USP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque USP2-4937R Recombinant Rhesus Macaque USP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque USP2-5124R Recombinant Rhesus monkey USP2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque USP2-4937R-B Recombinant Rhesus Macaque USP2 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • USP2 Related Articles
    • USP2 Related Signal Pathway

    USP2 involved in several pathways and played different roles in them. We selected most pathways USP2 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF-alpha/NF-kB Signaling PathwayUNC5CL;DPF2;MARK2;PAPOLA;FAF1;CAPN3;TRAIP;AKAP8;NR2C2
    TNFR1-induced NFkappaB signaling pathwayOTUD7B;USP2;SHARPIN;RNF31;USP4;SHRPRBCK1R
    TNFR1-induced proapoptotic signalingOTUD7B;USP4;USP2

    USP2 has several biochemical functions, for example, cyclin binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP2 itself. We selected most functions USP2 had, and list some proteins which have the same functions with USP2. You can find most of the proteins on our site.

    Function Related Protein
    cyclin bindingCDKN1A;CUL3;MDFIC;CDK13;USP2;CDK5RAP3;CDK2;CDK6;PFTK1
    cysteine-type endopeptidase activityUSP15;FMNL3;USP38;PSD;CTSB;USP45;CTSBA;USP27X;DUB1
    identical protein bindingCLDNG;GOT1;CDC42BPA;SMAD6;ERN1;AIM2;KHDC1B;CST3;STAT6
    metal ion bindingRNF187;TRPM6;CSGALNACT2;C2;NSF;PPP1CC;PRR3;ZNF829;MCCC1
    ubiquitin protein ligase bindingCCT2;EGFR;CASP10;MDM2;BCL10;CKB;LTBR;KCNQ3;CUL1B
    ubiquitin-specific protease activityZRANB1B;COPS5;BAP1;USP43;JOSD2;USP31;USP1;USP42;UFD1L

    USP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP2.


    Stes, E; Laga, M; et al. A COFRADIC Protocol To Study Protein Ubiquitination. JOURNAL OF PROTEOME RESEARCH 13:3107-3113(2014).
    Husted, RF; Lu, HY; et al. Oxygen regulation of the epithelial Na channel in the collecting duct. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F412-F424(2011).
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