USP2

  • Official Full Name

    ubiquitin specific peptidase 2

  • Overview

    This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Synonyms

    USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USP2-1042H Active Recombinant Human USP2 E.coli N/A
Human USP2-320H Active Recombinant human USP2 protein, FLAG-tagged Sf9 Insect Cell FLAG 2-605(end)
Human USP2-182H Active Recombinant Human USP2, GST-tagged E.coli GST
Human USP2-544H Active Recombinant Human USP2 Protein, His-tagged E.coli His
Human USP2-153H Recombinant Human USP2, His-tagged E.coli His
Human USP2-3620H Recombinant Human USP2, GST-tagged E.coli GST 11-241aa
Human USP2-468HCL Recombinant Human USP2 293 Cell Lysate HEK293 N/A
Human USP226316H Recombinant Human USP2 (258-605) Protein
Human USP2-011H Recombinant Human USP2 Protein, His-tagged E.coli His 259-605
Human USP2-092H Recombinant Human USP2 Protein, His-tagged E.coli His 259-605
Human USP2-0550H Recombinant Human USP2 Protein (N259-M605), His tagged E.coli His N259-M605
Human USP226345H Recombinant Human USP2 (260-605)-GSGSGS-FLAG-Ubiquitin (1-71) (E472A, K473A) Protein
Human USP2-0551H Recombinant Human USP2 Protein (N259-M605), Tag Free E.coli No tag N259-M605
Human USP216623H Recombinant Human USP2 (260-605)-GSGSGSTNTRPTNYPG-Ubiquitin (1-71) (E472A, K473A) Protein
Human USP2-886H Recombinant Human USP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse USP2-17909M Recombinant Mouse USP2 Protein Mammalian Cell His
Mouse Usp2-106M Recombinant Mouse Usp2 Protein, His-tagged E.coli His Met1~Gly219
Mouse USP2-9951M Recombinant Mouse USP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse USP2-9951M-B Recombinant Mouse USP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Usp2-6868M Recombinant Mouse Usp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat USP2-6473R Recombinant Rat USP2 Protein Mammalian Cell His
Rat Usp2-694R Recombinant Rat Usp2 protein E.coli N/A
Rat USP2-6129R-B Recombinant Rat USP2 Protein Pre-coupled Magnetic Beads HEK293
Rat USP2-6129R Recombinant Rat USP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque USP2-5124R Recombinant Rhesus monkey USP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque USP2-4937R-B Recombinant Rhesus Macaque USP2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque USP2-4937R Recombinant Rhesus Macaque USP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken USP2-6487C Recombinant Chicken USP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • USP2 Related Signal Pathway

USP2 involved in several pathways and played different roles in them. We selected most pathways USP2 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Death Receptor SignallingSHRPRBCK1R;GNB2L1;RNF31;TAB1;SHARPIN;OTUD7B;CYLD;TAX1BP1B;CLIP3
Regulation of TNFR1 signalingTAX1BP1;USP4;SHRPRBCK1R;RNF31;USP2;OTULINB;RBCK1;OTULIN;SHARPIN
Signal TransductionANXA1C;SCT;KISS1;CALML4;QRFP;DEPDC1B;LGR6;RBCK1;LPAR5A
TNF signalingRNF31;RBCK1;CLIP3;OTULINB;FAM105B;USP4;TAX1BP1B;SHARPIN;OTULIN
TNF-alpha/NF-kB Signaling PathwayDDX3X;ZFAND5;DCAF7;CAPN3;DPF2;FAF1;DAP;CRADD;KPNA6
TNFR1-induced NFkappaB signaling pathwaySHARPIN;RNF31;USP2;OTUD7B;USP4;SHRPRBCK1R
TNFR1-induced proapoptotic signalingUSP2;OTUD7B;USP4

USP2 has several biochemical functions, for example, cyclin binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP2 itself. We selected most functions USP2 had, and list some proteins which have the same functions with USP2. You can find most of the proteins on our site.

Function Related Protein
cyclin bindingMDFIC;CDKN1A;USP2;FBXW7;CDK14;CDK4;INCA1;HDAC3;PFTK1
cysteine-type endopeptidase activityUSP17L2;CTSW;CTSSB.2;CTSBB;USP8;USP27X;USP6;USP5;CTSL.1
identical protein bindingMPZL2B;CCL4;TRAF6;TRIM23;POLG2;HAND1;TP73;PCM1;LTBR
metal ion bindingPRLR;DICER1;ANTXR2A;CYP2AA2;PDLIM3A;MMP14B;ZKSCAN17;RAF1;ZNF615
protein bindingHPSE;CTU2;PPIL1;SRGAP3;PKN2;ARFGAP3;SPRR2E;POLB;MAP1LC3B
ubiquitin protein ligase bindingBLZF1;CUL1A;FAF1;PINK1;TNFRSF14;CUL4B;UCHL1;PA2G4;PPARGC1A
ubiquitin-specific protease activityUSP3;USP7;USP42;USP4;TNFAIP3;JOSD2;OTUB1;USP17L5;USP50

USP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP2.

KRT15; TRAF2; HOMER3; NEFL; TRIM27; GOLGA2

Research Area

Related articles

Stes, E; Laga, M; et al. A COFRADIC Protocol To Study Protein Ubiquitination. JOURNAL OF PROTEOME RESEARCH 13:3107-3113(2014).
Husted, RF; Lu, HY; et al. Oxygen regulation of the epithelial Na channel in the collecting duct. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F412-F424(2011).
  • Q&As
  • Reviews

Q&As (5)

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Can USP2 serve as a biomarker for certain diseases? 03/17/2022

It's possible. Elevated levels of USP2 have been associated with certain cancers and metabolic disorders, suggesting its potential as a biomarker for disease diagnosis and prognosis.

Are there any ongoing clinical trials targeting USP2 for diabetes treatment? 09/02/2021

There's research interest in exploring USP2 inhibitors to potentially improve insulin sensitivity and manage diabetes, but clinical trials in this area are still in early stages.

Are there any clinical studies exploring the use of USP2 inhibitors in cancer treatment? 09/01/2020

Yes, several studies are investigating USP2 inhibitors as potential therapeutic agents in cancer treatment to target specific pathways involved in tumor growth.

How does USP2 impact insulin sensitivity and diabetes? 05/27/2020

USP2 has been shown to regulate insulin signaling by deubiquitinating proteins involved in insulin receptor signaling pathways. Dysregulation of USP2 may contribute to insulin resistance in diabetes.

Can USP2 be a potential therapeutic target for drug development? 02/23/2018

Yes, due to its role in regulating protein stability, USP2 is being considered as a potential therapeutic target for drug development, especially in cancer and other diseases involving dysregulated protein turnover.

Customer Reviews (3)

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Reviews
09/14/2022

    Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

    03/09/2016

      With the USP2 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

      02/03/2016

        The USP2 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

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