USP2 involved in several pathways and played different roles in them. We selected most pathways USP2 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Death Receptor Signalling |
OTULIN; USP4; USP2; SHRPRBCK1R; FAM105B; TAB1; SHARPIN; OTUD7B; TAX1BP1; OTULINB |
| Regulation of TNFR1 signaling |
CLIP3; SHRPRBCK1R; USP2; OTULINB; OTULIN; TAX1BP1; USP4; FAM105B; TAX1BP1B; OTUD7B |
| Signal Transduction |
RHPN1; EVC; GRAP; OXER1; NOXA1; OPN1LW2; HEBP1; DHRS3A; NCKIPSD; ARHGAP6 |
| TNF signaling |
USP4; OTULIN; USP2; CLIP3; SHARPIN; OTUD7B; TAX1BP1; RBCK1; TAX1BP1B; OTULINB |
| TNF-alpha/NF-kB Signaling Pathway |
DCAF7; TANK; COMMD1; KPNA6; NR2C2; SMARCB1; MARK2; DDX3X; MCC; ZFAND5 |
| TNFR1-induced NFkappaB signaling pathway |
OTUD7B; SHARPIN; USP2; SHRPRBCK1R; RNF31; USP4 |
| TNFR1-induced proapoptotic signaling |
USP4; USP2; OTUD7B |
USP2 has several biochemical functions, for example, cyclin binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP2 itself. We selected most functions USP2 had, and list some proteins which have the same functions with USP2. You can find most of the proteins on our site.
| Function |
Related Protein |
| cyclin binding |
CDK2; CDK5RAP3; CDK14; CDK12; CUL3; CDK6; HDAC3; INCA1; PFTK1; MDFIC |
| cysteine-type endopeptidase activity |
USP17L5; USP42; FMNL3; PDIA3; UCHL1; USP13; USP16; CASPA; CTSLL; USP51 |
| identical protein binding |
KCNJ2; DVL1; SH2B2; PTS; GLUD1; SNRNP200; KCNJ10; MTPAP; RBM10; DNM1L |
| metal ion binding |
COL27A1A; PLEKHM1; ZNF354B; PRKCBB; ZDHHC14; PLRDGB; AOX4; NUDT10; NT5C2B; DUS3L |
| protein binding |
NRP1B; TAF12; LCMT2; ZNF511; CCDC36; INPP5B; GNE; PPM1K; SLC9A3; KLRB1B |
| ubiquitin protein ligase binding |
SPOP; PINK1; ARRB1; IKBKE; PCBP2; CUL3B; TRAF5; TPI1; UBOX5; UBE2G1B |
| ubiquitin-specific protease activity |
USP17L2; USP9X; IWS1; OTUB1; FMNL3; USP27X; USP12A; OTUD5A; USP7; USP47 |
USP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP2.
KRT15; TRAF2; HOMER3; NEFL; TRIM27; GOLGA2
Stes, E; Laga, M; et al. A COFRADIC Protocol To Study Protein Ubiquitination. JOURNAL OF PROTEOME RESEARCH 13:3107-3113(2014).
Husted, RF; Lu, HY; et al. Oxygen regulation of the epithelial Na channel in the collecting duct. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F412-F424(2011).
